NH4HCO3 gas-generating liposomal nanoparticle for photoacoustic imaging in breast cancer
Jizhu Xia, Gang Feng, Xiaorong Xia, Lan Hao, Zhigang Wang Chongqing Key Laboratory of Ultrasound Molecular Imaging, Department of Ultrasound, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China Abstract: In this study, we have developed a...
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Dove Medical Press
2017
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oai:doaj.org-article:4e98de4d6b784d438d74a13a2e3cd5822021-12-02T02:56:03ZNH4HCO3 gas-generating liposomal nanoparticle for photoacoustic imaging in breast cancer1178-2013https://doaj.org/article/4e98de4d6b784d438d74a13a2e3cd5822017-03-01T00:00:00Zhttps://www.dovepress.com/nh4hco3-gas-generating-liposomal-nanoparticle-for-photoacoustic-imagin-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Jizhu Xia, Gang Feng, Xiaorong Xia, Lan Hao, Zhigang Wang Chongqing Key Laboratory of Ultrasound Molecular Imaging, Department of Ultrasound, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China Abstract: In this study, we have developed a biodegradable nanomaterial for photoacoustic imaging (PAI). Its biodegradation products can be fully eliminated from a living organism. It is a gas-generating nanoparticle of liposome-encapsulating ammonium bicarbonate (NH4HCO3) solution, which is safe, effective, inexpensive, and free of side effects. When lasers irradiate these nanoparticles, NH4HCO3 decomposes to produce CO2, which can absorb much of the light energy under laser irradiation with a specific wavelength, and then expand under heat to generate a thermal acoustic wave. An acoustic detector can detect this wave and show it as a photoacoustic signal on a display screen. The intensity of the photoacoustic signal is enhanced corresponding to an increase in time, concentration, and temperature. During in vivo testing, nanoparticles were injected into tumor-bearing nude mice through the caudal vein, and photoacoustic signals were detected from the tumor, reaching a peak in 4 h, and then gradually disappearing. There was no damage to the skin or subcutaneous tissue from laser radiation. Our developed gas-generating nanomaterial, NH4HCO3 nanomaterial, is feasible, effective, safe, and inexpensive. Therefore, it is a promising material to be used in clinical PAI. Keywords: Photoacoustic tomography, CO2, NH4HCO3, contrast agent, cancerXia JFeng GXia XHao LWang ZDove Medical Pressarticlephotoacoustic imaginggas-generatingammonium bicarbonatenanoparticlecontrast agentbreast cancerMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 1803-1813 (2017) |
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photoacoustic imaging gas-generating ammonium bicarbonate nanoparticle contrast agent breast cancer Medicine (General) R5-920 |
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photoacoustic imaging gas-generating ammonium bicarbonate nanoparticle contrast agent breast cancer Medicine (General) R5-920 Xia J Feng G Xia X Hao L Wang Z NH4HCO3 gas-generating liposomal nanoparticle for photoacoustic imaging in breast cancer |
| description |
Jizhu Xia, Gang Feng, Xiaorong Xia, Lan Hao, Zhigang Wang Chongqing Key Laboratory of Ultrasound Molecular Imaging, Department of Ultrasound, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China Abstract: In this study, we have developed a biodegradable nanomaterial for photoacoustic imaging (PAI). Its biodegradation products can be fully eliminated from a living organism. It is a gas-generating nanoparticle of liposome-encapsulating ammonium bicarbonate (NH4HCO3) solution, which is safe, effective, inexpensive, and free of side effects. When lasers irradiate these nanoparticles, NH4HCO3 decomposes to produce CO2, which can absorb much of the light energy under laser irradiation with a specific wavelength, and then expand under heat to generate a thermal acoustic wave. An acoustic detector can detect this wave and show it as a photoacoustic signal on a display screen. The intensity of the photoacoustic signal is enhanced corresponding to an increase in time, concentration, and temperature. During in vivo testing, nanoparticles were injected into tumor-bearing nude mice through the caudal vein, and photoacoustic signals were detected from the tumor, reaching a peak in 4 h, and then gradually disappearing. There was no damage to the skin or subcutaneous tissue from laser radiation. Our developed gas-generating nanomaterial, NH4HCO3 nanomaterial, is feasible, effective, safe, and inexpensive. Therefore, it is a promising material to be used in clinical PAI. Keywords: Photoacoustic tomography, CO2, NH4HCO3, contrast agent, cancer |
| format |
article |
| author |
Xia J Feng G Xia X Hao L Wang Z |
| author_facet |
Xia J Feng G Xia X Hao L Wang Z |
| author_sort |
Xia J |
| title |
NH4HCO3 gas-generating liposomal nanoparticle for photoacoustic imaging in breast cancer |
| title_short |
NH4HCO3 gas-generating liposomal nanoparticle for photoacoustic imaging in breast cancer |
| title_full |
NH4HCO3 gas-generating liposomal nanoparticle for photoacoustic imaging in breast cancer |
| title_fullStr |
NH4HCO3 gas-generating liposomal nanoparticle for photoacoustic imaging in breast cancer |
| title_full_unstemmed |
NH4HCO3 gas-generating liposomal nanoparticle for photoacoustic imaging in breast cancer |
| title_sort |
nh4hco3 gas-generating liposomal nanoparticle for photoacoustic imaging in breast cancer |
| publisher |
Dove Medical Press |
| publishDate |
2017 |
| url |
https://doaj.org/article/4e98de4d6b784d438d74a13a2e3cd582 |
| work_keys_str_mv |
AT xiaj nh4hco3nbspgasgeneratingliposomalnanoparticleforphotoacousticimaginginbreastcancer AT fengg nh4hco3nbspgasgeneratingliposomalnanoparticleforphotoacousticimaginginbreastcancer AT xiax nh4hco3nbspgasgeneratingliposomalnanoparticleforphotoacousticimaginginbreastcancer AT haol nh4hco3nbspgasgeneratingliposomalnanoparticleforphotoacousticimaginginbreastcancer AT wangz nh4hco3nbspgasgeneratingliposomalnanoparticleforphotoacousticimaginginbreastcancer |
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