Noninvasively characterizing the different αvβ3 expression patterns in lung cancers with RGD-USPIO using a clinical 3.0T MR scanner

Noninvasively characterizing the different αvβ3 expression patterns in lung cancers with RGD-USPIO using a clinical 3.0T MR scanner

Tao Jiang1,*, Chunfu Zhang2, Xuan Zheng3,*, Xiongfei Xu4, Xuan Xie2, Hongchao Liu1, Shiyuan Liu11Department of Radiology, ChangZheng Hospital Affiliated to Second Military Medical University, 415 Fengyang Road, Shanghai, China; 2Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, Chin...

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Autores principales: Tao Jiang, Chunfu Zhang, Xuan Zheng, et al
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2009
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Medicine (General)
R5-920
Acceso en línea:https://doaj.org/article/4e9bc4d8077247ac8154a023a89151f5
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spelling oai:doaj.org-article:4e9bc4d8077247ac8154a023a89151f52021-12-02T00:40:16ZNoninvasively characterizing the different αvβ3 expression patterns in lung cancers with RGD-USPIO using a clinical 3.0T MR scanner1176-91141178-2013https://doaj.org/article/4e9bc4d8077247ac8154a023a89151f52009-11-01T00:00:00Zhttp://www.dovepress.com/noninvasively-characterizing-the-different-alphavbeta3-expression-patt-a3722https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Tao Jiang1,*, Chunfu Zhang2, Xuan Zheng3,*, Xiongfei Xu4, Xuan Xie2, Hongchao Liu1, Shiyuan Liu11Department of Radiology, ChangZheng Hospital Affiliated to Second Military Medical University, 415 Fengyang Road, Shanghai, China; 2Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, China; 3Department of Nutrition, Changhai Hospital Affiliated to Second Military Medical University, Shanghai, China; 4Department of Immunology, Second Military Medical University, Shanghai, China; *These authors contributed equally to this workAbstract: The adhesion molecule αvβ3 integrin plays an important role in tumor development and metastases. We demonstrated the specificity of the probe to αvβ3 integrin with transmission electron microcopy (TEM) and magnetic resonance imaging (MRI). The in vivo targeting behavior of the probe was examined in 2 tumor models with different αvβ3 expression patterns by a 3.0T MRI scanner. MR imaging showed that R2* pseudo-color pictures of A549 lung cancer tumor was different from that of 3LL lung cancer. For A549 tumor, an homogeneous decrease of signal intensity was observed throughout the tumor, which was more evident in the periphery or central areas. Histological studies revealed that αvβ3 integrin was expressed both on the tumor vessel and tumor cells for A549 tumor. Our findings indicated that it was possible to noninvasively characterize the different αvβ3 expression pattern in lung cancers with arginine-glycine-aspartic acid (RGD) peptide conjugated ultra-small superparamagnetic iron oxide nanoparticles (RGD-USPIO) using a clinical 3.0T MR scanner. Nevertheless, the way of imaging targeting presentation of the probe differed in tumors with different αvβ3 expression patterns.Keywords: USPIO, RGD peptide, αvβ3 integrin, MR molecular imaging Tao JiangChunfu ZhangXuan Zhenget alDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2009, Iss default, Pp 241-249 (2009)
institution DOAJ
collection DOAJ
language EN
topic Medicine (General)
R5-920
spellingShingle Medicine (General)
R5-920
Tao Jiang
Chunfu Zhang
Xuan Zheng
et al
Noninvasively characterizing the different αvβ3 expression patterns in lung cancers with RGD-USPIO using a clinical 3.0T MR scanner
description Tao Jiang1,*, Chunfu Zhang2, Xuan Zheng3,*, Xiongfei Xu4, Xuan Xie2, Hongchao Liu1, Shiyuan Liu11Department of Radiology, ChangZheng Hospital Affiliated to Second Military Medical University, 415 Fengyang Road, Shanghai, China; 2Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, China; 3Department of Nutrition, Changhai Hospital Affiliated to Second Military Medical University, Shanghai, China; 4Department of Immunology, Second Military Medical University, Shanghai, China; *These authors contributed equally to this workAbstract: The adhesion molecule αvβ3 integrin plays an important role in tumor development and metastases. We demonstrated the specificity of the probe to αvβ3 integrin with transmission electron microcopy (TEM) and magnetic resonance imaging (MRI). The in vivo targeting behavior of the probe was examined in 2 tumor models with different αvβ3 expression patterns by a 3.0T MRI scanner. MR imaging showed that R2* pseudo-color pictures of A549 lung cancer tumor was different from that of 3LL lung cancer. For A549 tumor, an homogeneous decrease of signal intensity was observed throughout the tumor, which was more evident in the periphery or central areas. Histological studies revealed that αvβ3 integrin was expressed both on the tumor vessel and tumor cells for A549 tumor. Our findings indicated that it was possible to noninvasively characterize the different αvβ3 expression pattern in lung cancers with arginine-glycine-aspartic acid (RGD) peptide conjugated ultra-small superparamagnetic iron oxide nanoparticles (RGD-USPIO) using a clinical 3.0T MR scanner. Nevertheless, the way of imaging targeting presentation of the probe differed in tumors with different αvβ3 expression patterns.Keywords: USPIO, RGD peptide, αvβ3 integrin, MR molecular imaging
format article
author Tao Jiang
Chunfu Zhang
Xuan Zheng
et al
author_facet Tao Jiang
Chunfu Zhang
Xuan Zheng
et al
author_sort Tao Jiang
title Noninvasively characterizing the different αvβ3 expression patterns in lung cancers with RGD-USPIO using a clinical 3.0T MR scanner
title_short Noninvasively characterizing the different αvβ3 expression patterns in lung cancers with RGD-USPIO using a clinical 3.0T MR scanner
title_full Noninvasively characterizing the different αvβ3 expression patterns in lung cancers with RGD-USPIO using a clinical 3.0T MR scanner
title_fullStr Noninvasively characterizing the different αvβ3 expression patterns in lung cancers with RGD-USPIO using a clinical 3.0T MR scanner
title_full_unstemmed Noninvasively characterizing the different αvβ3 expression patterns in lung cancers with RGD-USPIO using a clinical 3.0T MR scanner
title_sort noninvasively characterizing the different αvβ3 expression patterns in lung cancers with rgd-uspio using a clinical 3.0t mr scanner
publisher Dove Medical Press
publishDate 2009
url https://doaj.org/article/4e9bc4d8077247ac8154a023a89151f5
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