Cognitive brain responses during circadian wake-promotion: evidence for sleep-pressure-dependent hypothalamic activations

Abstract The two-process model of sleep-wake regulation posits that sleep-wake-dependent homeostatic processes interact with the circadian timing system to affect human behavior. The circadian timing system is fundamental to maintaining stable cognitive performance, as it counteracts growing homeost...

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Autores principales:	Carolin F. Reichert, Micheline Maire, Virginie Gabel, Antoine U. Viola, Thomas Götz, Klaus Scheffler, Markus Klarhöfer, Christian Berthomier, Werner Strobel, Christophe Phillips, Eric Salmon, Christian Cajochen, Christina Schmidt
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4e9e94685be94459975422e0b8251562
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spelling	oai:doaj.org-article:4e9e94685be94459975422e0b82515622021-12-02T12:30:18ZCognitive brain responses during circadian wake-promotion: evidence for sleep-pressure-dependent hypothalamic activations10.1038/s41598-017-05695-12045-2322https://doaj.org/article/4e9e94685be94459975422e0b82515622017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05695-1https://doaj.org/toc/2045-2322Abstract The two-process model of sleep-wake regulation posits that sleep-wake-dependent homeostatic processes interact with the circadian timing system to affect human behavior. The circadian timing system is fundamental to maintaining stable cognitive performance, as it counteracts growing homeostatic sleep pressure during daytime. Using magnetic resonance imaging, we explored brain responses underlying working memory performance during the time of maximal circadian wake-promotion under varying sleep pressure conditions. Circadian wake-promoting strength was derived from the ability to sleep during an evening nap. Hypothalamic BOLD activity was positively linked to circadian wake-promoting strength under normal, but not under disproportionally high or low sleep pressure levels. Furthermore, higher hypothalamic activity under normal sleep pressure levels predicted better performance under sleep loss. Our results reappraise the two-process model by revealing a homeostatic-dose-dependent association between circadian wake-promotion and cognition-related hypothalamic activity.Carolin F. ReichertMicheline MaireVirginie GabelAntoine U. ViolaThomas GötzKlaus SchefflerMarkus KlarhöferChristian BerthomierWerner StrobelChristophe PhillipsEric SalmonChristian CajochenChristina SchmidtNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Carolin F. Reichert Micheline Maire Virginie Gabel Antoine U. Viola Thomas Götz Klaus Scheffler Markus Klarhöfer Christian Berthomier Werner Strobel Christophe Phillips Eric Salmon Christian Cajochen Christina Schmidt Cognitive brain responses during circadian wake-promotion: evidence for sleep-pressure-dependent hypothalamic activations
description	Abstract The two-process model of sleep-wake regulation posits that sleep-wake-dependent homeostatic processes interact with the circadian timing system to affect human behavior. The circadian timing system is fundamental to maintaining stable cognitive performance, as it counteracts growing homeostatic sleep pressure during daytime. Using magnetic resonance imaging, we explored brain responses underlying working memory performance during the time of maximal circadian wake-promotion under varying sleep pressure conditions. Circadian wake-promoting strength was derived from the ability to sleep during an evening nap. Hypothalamic BOLD activity was positively linked to circadian wake-promoting strength under normal, but not under disproportionally high or low sleep pressure levels. Furthermore, higher hypothalamic activity under normal sleep pressure levels predicted better performance under sleep loss. Our results reappraise the two-process model by revealing a homeostatic-dose-dependent association between circadian wake-promotion and cognition-related hypothalamic activity.
format	article
author	Carolin F. Reichert Micheline Maire Virginie Gabel Antoine U. Viola Thomas Götz Klaus Scheffler Markus Klarhöfer Christian Berthomier Werner Strobel Christophe Phillips Eric Salmon Christian Cajochen Christina Schmidt
author_facet	Carolin F. Reichert Micheline Maire Virginie Gabel Antoine U. Viola Thomas Götz Klaus Scheffler Markus Klarhöfer Christian Berthomier Werner Strobel Christophe Phillips Eric Salmon Christian Cajochen Christina Schmidt
author_sort	Carolin F. Reichert
title	Cognitive brain responses during circadian wake-promotion: evidence for sleep-pressure-dependent hypothalamic activations
title_short	Cognitive brain responses during circadian wake-promotion: evidence for sleep-pressure-dependent hypothalamic activations
title_full	Cognitive brain responses during circadian wake-promotion: evidence for sleep-pressure-dependent hypothalamic activations
title_fullStr	Cognitive brain responses during circadian wake-promotion: evidence for sleep-pressure-dependent hypothalamic activations
title_full_unstemmed	Cognitive brain responses during circadian wake-promotion: evidence for sleep-pressure-dependent hypothalamic activations
title_sort	cognitive brain responses during circadian wake-promotion: evidence for sleep-pressure-dependent hypothalamic activations
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/4e9e94685be94459975422e0b8251562
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Cognitive brain responses during circadian wake-promotion: evidence for sleep-pressure-dependent hypothalamic activations

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