Distribution of subcutaneous and intermuscular fatty tissue of the mid-thigh measured by MRI—A putative indicator of serum adiponectin level and individual factors of cardio-metabolic risk

Obesity and metabolic syndrome (MetS) are associated with hypoadiponectinemia. On the contrary, studies revealed correlations between the amount of subcutaneous adipose tissue (SAT) and higher serum adiponectin levels. Furthermore, independent association of intermuscular adipose tissue (IMAT) depos...

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Autores principales:	Eva Maria Hassler, Hannes Deutschmann, Gunter Almer, Wilfried Renner, Harald Mangge, Markus Herrmann, Stefan Leber, Manuela Michenthaler, Alexander Staszewski, Felix Gunzer, Richard Partl, Gernot Reishofer
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4e9f6ce526f14a708ec77e6fc7d18815
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spelling	oai:doaj.org-article:4e9f6ce526f14a708ec77e6fc7d188152021-11-25T06:10:57ZDistribution of subcutaneous and intermuscular fatty tissue of the mid-thigh measured by MRI—A putative indicator of serum adiponectin level and individual factors of cardio-metabolic risk1932-6203https://doaj.org/article/4e9f6ce526f14a708ec77e6fc7d188152021-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8592416/?tool=EBIhttps://doaj.org/toc/1932-6203Obesity and metabolic syndrome (MetS) are associated with hypoadiponectinemia. On the contrary, studies revealed correlations between the amount of subcutaneous adipose tissue (SAT) and higher serum adiponectin levels. Furthermore, independent association of intermuscular adipose tissue (IMAT) deposit in the thigh with cardiometabolic risk factors (including total blood cholesterol, low-density lipoprotein (LDL), and triglycerides), and decreased insulin sensitivity, as MetS components, are sufficiently described. The combined relationship of thigh IMAT and SAT with serum adiponectin, leptin levels, and cardiometabolic risk factors have not been investigated till date. Since both SAT and IMAT play a role in fat metabolism, we hypothesized that the distribution pattern of SAT and IMAT in the mid-thigh might be related to adiponectin, leptin levels, and serum lipid parameters. We performed adipose tissue quantification using magnetic resonance imaging (MRI) of the mid-thigh in 156 healthy volunteers (78 male/78 female). Laboratory measurements of lipid panel, serum adiponectin, and leptin levels were conducted. Total serum adiponectin level showed a significant correlation with the percentage of SAT of the total thigh adipose tissue (SAT/ (IMAT+SAT)) for the whole study population and in sex-specific analysis. Additionally, SAT/(IMAT+SAT) was negatively correlated with known cardiometabolic risk factors such as elevated total blood cholesterol, LDL, and triglycerides; but positively correlated with serum high-density lipoprotein. In multiple linear regression analysis, (SAT/(IMAT+SAT)) was the most strongly associated variable with adiponectin. Interestingly, leptin levels did not show a significant correlation with this ratio. Adipose tissue distribution in the mid-thigh is not only associated to serum adiponectin levels, independent of sex. This proposed quantitative parameter for adipose tissue distribution could be an indicator for individual factors of a person`s cardiometabolic risk and serve as additional non-invasive imaging marker to ensure the success of lifestyle interventions.Eva Maria HasslerHannes DeutschmannGunter AlmerWilfried RennerHarald ManggeMarkus HerrmannStefan LeberManuela MichenthalerAlexander StaszewskiFelix GunzerRichard PartlGernot ReishoferPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Eva Maria Hassler Hannes Deutschmann Gunter Almer Wilfried Renner Harald Mangge Markus Herrmann Stefan Leber Manuela Michenthaler Alexander Staszewski Felix Gunzer Richard Partl Gernot Reishofer Distribution of subcutaneous and intermuscular fatty tissue of the mid-thigh measured by MRI—A putative indicator of serum adiponectin level and individual factors of cardio-metabolic risk
description	Obesity and metabolic syndrome (MetS) are associated with hypoadiponectinemia. On the contrary, studies revealed correlations between the amount of subcutaneous adipose tissue (SAT) and higher serum adiponectin levels. Furthermore, independent association of intermuscular adipose tissue (IMAT) deposit in the thigh with cardiometabolic risk factors (including total blood cholesterol, low-density lipoprotein (LDL), and triglycerides), and decreased insulin sensitivity, as MetS components, are sufficiently described. The combined relationship of thigh IMAT and SAT with serum adiponectin, leptin levels, and cardiometabolic risk factors have not been investigated till date. Since both SAT and IMAT play a role in fat metabolism, we hypothesized that the distribution pattern of SAT and IMAT in the mid-thigh might be related to adiponectin, leptin levels, and serum lipid parameters. We performed adipose tissue quantification using magnetic resonance imaging (MRI) of the mid-thigh in 156 healthy volunteers (78 male/78 female). Laboratory measurements of lipid panel, serum adiponectin, and leptin levels were conducted. Total serum adiponectin level showed a significant correlation with the percentage of SAT of the total thigh adipose tissue (SAT/ (IMAT+SAT)) for the whole study population and in sex-specific analysis. Additionally, SAT/(IMAT+SAT) was negatively correlated with known cardiometabolic risk factors such as elevated total blood cholesterol, LDL, and triglycerides; but positively correlated with serum high-density lipoprotein. In multiple linear regression analysis, (SAT/(IMAT+SAT)) was the most strongly associated variable with adiponectin. Interestingly, leptin levels did not show a significant correlation with this ratio. Adipose tissue distribution in the mid-thigh is not only associated to serum adiponectin levels, independent of sex. This proposed quantitative parameter for adipose tissue distribution could be an indicator for individual factors of a person`s cardiometabolic risk and serve as additional non-invasive imaging marker to ensure the success of lifestyle interventions.
format	article
author	Eva Maria Hassler Hannes Deutschmann Gunter Almer Wilfried Renner Harald Mangge Markus Herrmann Stefan Leber Manuela Michenthaler Alexander Staszewski Felix Gunzer Richard Partl Gernot Reishofer
author_facet	Eva Maria Hassler Hannes Deutschmann Gunter Almer Wilfried Renner Harald Mangge Markus Herrmann Stefan Leber Manuela Michenthaler Alexander Staszewski Felix Gunzer Richard Partl Gernot Reishofer
author_sort	Eva Maria Hassler
title	Distribution of subcutaneous and intermuscular fatty tissue of the mid-thigh measured by MRI—A putative indicator of serum adiponectin level and individual factors of cardio-metabolic risk
title_short	Distribution of subcutaneous and intermuscular fatty tissue of the mid-thigh measured by MRI—A putative indicator of serum adiponectin level and individual factors of cardio-metabolic risk
title_full	Distribution of subcutaneous and intermuscular fatty tissue of the mid-thigh measured by MRI—A putative indicator of serum adiponectin level and individual factors of cardio-metabolic risk
title_fullStr	Distribution of subcutaneous and intermuscular fatty tissue of the mid-thigh measured by MRI—A putative indicator of serum adiponectin level and individual factors of cardio-metabolic risk
title_full_unstemmed	Distribution of subcutaneous and intermuscular fatty tissue of the mid-thigh measured by MRI—A putative indicator of serum adiponectin level and individual factors of cardio-metabolic risk
title_sort	distribution of subcutaneous and intermuscular fatty tissue of the mid-thigh measured by mri—a putative indicator of serum adiponectin level and individual factors of cardio-metabolic risk
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/4e9f6ce526f14a708ec77e6fc7d18815
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Distribution of subcutaneous and intermuscular fatty tissue of the mid-thigh measured by MRI—A putative indicator of serum adiponectin level and individual factors of cardio-metabolic risk

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