Specific microstructural changes of the cervical spinal cord in syringomyelia estimated by diffusion tensor imaging

Abstract The microstructure of the spinal cord in syringomyelia has not been well studied. The aim of this study was to evaluate the microstructure of the cervical cord in patients with syringomyelia using diffusion tensor imaging (DTI) and to investigate the association between DTI parameters and t...

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Autores principales:	Weifei Wu, Xiangxiang Li, Zong Yang, Neng Ru, Fan Zhang, Jie Liang, Ke Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4ea09ba1be9a43359568ede38c3c7215
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spelling	oai:doaj.org-article:4ea09ba1be9a43359568ede38c3c72152021-12-02T11:35:52ZSpecific microstructural changes of the cervical spinal cord in syringomyelia estimated by diffusion tensor imaging10.1038/s41598-021-84164-22045-2322https://doaj.org/article/4ea09ba1be9a43359568ede38c3c72152021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84164-2https://doaj.org/toc/2045-2322Abstract The microstructure of the spinal cord in syringomyelia has not been well studied. The aim of this study was to evaluate the microstructure of the cervical cord in patients with syringomyelia using diffusion tensor imaging (DTI) and to investigate the association between DTI parameters and the size of the syrinx cavity. Thirty patients with syringomyelia and 11 age-matched controls were included in this study. DTI and T1/T2-weighted MRI were used to estimate spinal microstructure. The patients were divided into a clinical symptom group (group A) and a non-clinical symptom group (group B) according to ASIA assessments. The fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values (mm2/s) were measured and compared between patients and controls. Correlation between FA/ADC and the size of the syrinx cavity was examined with a bivariate analysis. FA values were lower (P < 0.000) and ADC values were higher (P < 0.000) compared to the controls at the level of all syrinxes examined in patients with syringomyelia; both FA values and ADC values reached normal values either above or below the syrinx levels (all P > 0.05). FA values and ADC values at all cervical levels were not significantly different either in controls or outside of the syrinx (all P > 0.05). FA values of group A was significantly lower than those of group B (P < 0.000). There was a negative association between FA values and the size of syrinx cavity, and a positive association between ADC values and the size of syrinx cavity (FA: P < 0.05, ADC: P < 0.05). The microstructure of the cervical spinal cord is different across all patients with syringomyelia. DTI is a promising tool for estimating quantitative pathological characteristics that are not visible with general MRI.Weifei WuXiangxiang LiZong YangNeng RuFan ZhangJie LiangKe ZhangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Weifei Wu Xiangxiang Li Zong Yang Neng Ru Fan Zhang Jie Liang Ke Zhang Specific microstructural changes of the cervical spinal cord in syringomyelia estimated by diffusion tensor imaging
description	Abstract The microstructure of the spinal cord in syringomyelia has not been well studied. The aim of this study was to evaluate the microstructure of the cervical cord in patients with syringomyelia using diffusion tensor imaging (DTI) and to investigate the association between DTI parameters and the size of the syrinx cavity. Thirty patients with syringomyelia and 11 age-matched controls were included in this study. DTI and T1/T2-weighted MRI were used to estimate spinal microstructure. The patients were divided into a clinical symptom group (group A) and a non-clinical symptom group (group B) according to ASIA assessments. The fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values (mm2/s) were measured and compared between patients and controls. Correlation between FA/ADC and the size of the syrinx cavity was examined with a bivariate analysis. FA values were lower (P < 0.000) and ADC values were higher (P < 0.000) compared to the controls at the level of all syrinxes examined in patients with syringomyelia; both FA values and ADC values reached normal values either above or below the syrinx levels (all P > 0.05). FA values and ADC values at all cervical levels were not significantly different either in controls or outside of the syrinx (all P > 0.05). FA values of group A was significantly lower than those of group B (P < 0.000). There was a negative association between FA values and the size of syrinx cavity, and a positive association between ADC values and the size of syrinx cavity (FA: P < 0.05, ADC: P < 0.05). The microstructure of the cervical spinal cord is different across all patients with syringomyelia. DTI is a promising tool for estimating quantitative pathological characteristics that are not visible with general MRI.
format	article
author	Weifei Wu Xiangxiang Li Zong Yang Neng Ru Fan Zhang Jie Liang Ke Zhang
author_facet	Weifei Wu Xiangxiang Li Zong Yang Neng Ru Fan Zhang Jie Liang Ke Zhang
author_sort	Weifei Wu
title	Specific microstructural changes of the cervical spinal cord in syringomyelia estimated by diffusion tensor imaging
title_short	Specific microstructural changes of the cervical spinal cord in syringomyelia estimated by diffusion tensor imaging
title_full	Specific microstructural changes of the cervical spinal cord in syringomyelia estimated by diffusion tensor imaging
title_fullStr	Specific microstructural changes of the cervical spinal cord in syringomyelia estimated by diffusion tensor imaging
title_full_unstemmed	Specific microstructural changes of the cervical spinal cord in syringomyelia estimated by diffusion tensor imaging
title_sort	specific microstructural changes of the cervical spinal cord in syringomyelia estimated by diffusion tensor imaging
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4ea09ba1be9a43359568ede38c3c7215
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Specific microstructural changes of the cervical spinal cord in syringomyelia estimated by diffusion tensor imaging

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