A practical solution to pseudoreplication bias in single-cell studies

Single cell genomics uses cells from the same individual, or pseudoreplicates, that can introduce biases and inflate type I error rates. Here the authors apply generalized linear mixed models with a random effect for individual, to properly account for both zero inflation and the correlation structu...

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Detalles Bibliográficos
Autores principales:	Kip D. Zimmerman, Mark A. Espeland, Carl D. Langefeld
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4ea0a83617e1448592a554d93a96ffb4
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spelling	oai:doaj.org-article:4ea0a83617e1448592a554d93a96ffb42021-12-02T14:06:28ZA practical solution to pseudoreplication bias in single-cell studies10.1038/s41467-021-21038-12041-1723https://doaj.org/article/4ea0a83617e1448592a554d93a96ffb42021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21038-1https://doaj.org/toc/2041-1723Single cell genomics uses cells from the same individual, or pseudoreplicates, that can introduce biases and inflate type I error rates. Here the authors apply generalized linear mixed models with a random effect for individual, to properly account for both zero inflation and the correlation structure among cells within an individual.Kip D. ZimmermanMark A. EspelandCarl D. LangefeldNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kip D. Zimmerman Mark A. Espeland Carl D. Langefeld A practical solution to pseudoreplication bias in single-cell studies
description	Single cell genomics uses cells from the same individual, or pseudoreplicates, that can introduce biases and inflate type I error rates. Here the authors apply generalized linear mixed models with a random effect for individual, to properly account for both zero inflation and the correlation structure among cells within an individual.
format	article
author	Kip D. Zimmerman Mark A. Espeland Carl D. Langefeld
author_facet	Kip D. Zimmerman Mark A. Espeland Carl D. Langefeld
author_sort	Kip D. Zimmerman
title	A practical solution to pseudoreplication bias in single-cell studies
title_short	A practical solution to pseudoreplication bias in single-cell studies
title_full	A practical solution to pseudoreplication bias in single-cell studies
title_fullStr	A practical solution to pseudoreplication bias in single-cell studies
title_full_unstemmed	A practical solution to pseudoreplication bias in single-cell studies
title_sort	practical solution to pseudoreplication bias in single-cell studies
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4ea0a83617e1448592a554d93a96ffb4
work_keys_str_mv	AT kipdzimmerman apracticalsolutiontopseudoreplicationbiasinsinglecellstudies AT markaespeland apracticalsolutiontopseudoreplicationbiasinsinglecellstudies AT carldlangefeld apracticalsolutiontopseudoreplicationbiasinsinglecellstudies AT kipdzimmerman practicalsolutiontopseudoreplicationbiasinsinglecellstudies AT markaespeland practicalsolutiontopseudoreplicationbiasinsinglecellstudies AT carldlangefeld practicalsolutiontopseudoreplicationbiasinsinglecellstudies
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A practical solution to pseudoreplication bias in single-cell studies

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