Quantitative model of eukaryotic Cdk control through the Forkhead CONTROLLER

Abstract In budding yeast, synchronization of waves of mitotic cyclins that activate the Cdk1 kinase occur through Forkhead transcription factors. These molecules act as controllers of their sequential order and may account for the separation in time of incompatible processes. Here, a Forkhead-media...

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Autor principal:	Matteo Barberis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/4ea17fb032bc40cf8f7a91d6c5d37404
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spelling	oai:doaj.org-article:4ea17fb032bc40cf8f7a91d6c5d374042021-12-02T17:48:01ZQuantitative model of eukaryotic Cdk control through the Forkhead CONTROLLER10.1038/s41540-021-00187-52056-7189https://doaj.org/article/4ea17fb032bc40cf8f7a91d6c5d374042021-06-01T00:00:00Zhttps://doi.org/10.1038/s41540-021-00187-5https://doaj.org/toc/2056-7189Abstract In budding yeast, synchronization of waves of mitotic cyclins that activate the Cdk1 kinase occur through Forkhead transcription factors. These molecules act as controllers of their sequential order and may account for the separation in time of incompatible processes. Here, a Forkhead-mediated design principle underlying the quantitative model of Cdk control is proposed for budding yeast. This design rationalizes timing of cell division, through progressive and coordinated cyclin/Cdk-mediated phosphorylation of Forkhead, and autonomous cyclin/Cdk oscillations. A “clock unit” incorporating this design that regulates timing of cell division is proposed for both yeast and mammals, and has a DRIVER operating the incompatible processes that is instructed by multiple CLOCKS. TIMERS determine whether the clocks are active, whereas CONTROLLERS determine how quickly the clocks shall function depending on external MODULATORS. This “clock unit” may coordinate temporal waves of cyclin/Cdk concentration/activity in the eukaryotic cell cycle making the driver operate the incompatible processes, at separate times.Matteo BarberisNature PortfolioarticleBiology (General)QH301-705.5ENnpj Systems Biology and Applications, Vol 7, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Matteo Barberis Quantitative model of eukaryotic Cdk control through the Forkhead CONTROLLER
description	Abstract In budding yeast, synchronization of waves of mitotic cyclins that activate the Cdk1 kinase occur through Forkhead transcription factors. These molecules act as controllers of their sequential order and may account for the separation in time of incompatible processes. Here, a Forkhead-mediated design principle underlying the quantitative model of Cdk control is proposed for budding yeast. This design rationalizes timing of cell division, through progressive and coordinated cyclin/Cdk-mediated phosphorylation of Forkhead, and autonomous cyclin/Cdk oscillations. A “clock unit” incorporating this design that regulates timing of cell division is proposed for both yeast and mammals, and has a DRIVER operating the incompatible processes that is instructed by multiple CLOCKS. TIMERS determine whether the clocks are active, whereas CONTROLLERS determine how quickly the clocks shall function depending on external MODULATORS. This “clock unit” may coordinate temporal waves of cyclin/Cdk concentration/activity in the eukaryotic cell cycle making the driver operate the incompatible processes, at separate times.
format	article
author	Matteo Barberis
author_facet	Matteo Barberis
author_sort	Matteo Barberis
title	Quantitative model of eukaryotic Cdk control through the Forkhead CONTROLLER
title_short	Quantitative model of eukaryotic Cdk control through the Forkhead CONTROLLER
title_full	Quantitative model of eukaryotic Cdk control through the Forkhead CONTROLLER
title_fullStr	Quantitative model of eukaryotic Cdk control through the Forkhead CONTROLLER
title_full_unstemmed	Quantitative model of eukaryotic Cdk control through the Forkhead CONTROLLER
title_sort	quantitative model of eukaryotic cdk control through the forkhead controller
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4ea17fb032bc40cf8f7a91d6c5d37404
work_keys_str_mv	AT matteobarberis quantitativemodelofeukaryoticcdkcontrolthroughtheforkheadcontroller
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Quantitative model of eukaryotic Cdk control through the Forkhead CONTROLLER

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