The opposing forces of shear flow and sphingosine-1-phosphate control marginal zone B cell shuttling
Marginal zone B (MZB) cells shuttle between the marginal zone and lymphoid follicle to capture and present peripheral blood antigens. Here the authors show that shear force, such as blood flow from the sinus around the follicle, is a directional cue that induces MZB migration on ICAM-1, and that S1P...
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Nature Portfolio
2017
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oai:doaj.org-article:4ea3d978a3034f2a94cc0a2735ba5f3c2021-12-02T17:01:17ZThe opposing forces of shear flow and sphingosine-1-phosphate control marginal zone B cell shuttling10.1038/s41467-017-02482-42041-1723https://doaj.org/article/4ea3d978a3034f2a94cc0a2735ba5f3c2017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02482-4https://doaj.org/toc/2041-1723Marginal zone B (MZB) cells shuttle between the marginal zone and lymphoid follicle to capture and present peripheral blood antigens. Here the authors show that shear force, such as blood flow from the sinus around the follicle, is a directional cue that induces MZB migration on ICAM-1, and that S1P signaling inhibits this directional migration.Kerry TedfordMichael SteinerStanislav KoshutinKarin RichterLaura TechYannik EggersInga JansingKerstin SchillingAnja Erika HauserMark KorthalsKlaus-Dieter FischerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017) |
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DOAJ |
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DOAJ |
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EN |
| topic |
Science Q |
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Science Q Kerry Tedford Michael Steiner Stanislav Koshutin Karin Richter Laura Tech Yannik Eggers Inga Jansing Kerstin Schilling Anja Erika Hauser Mark Korthals Klaus-Dieter Fischer The opposing forces of shear flow and sphingosine-1-phosphate control marginal zone B cell shuttling |
| description |
Marginal zone B (MZB) cells shuttle between the marginal zone and lymphoid follicle to capture and present peripheral blood antigens. Here the authors show that shear force, such as blood flow from the sinus around the follicle, is a directional cue that induces MZB migration on ICAM-1, and that S1P signaling inhibits this directional migration. |
| format |
article |
| author |
Kerry Tedford Michael Steiner Stanislav Koshutin Karin Richter Laura Tech Yannik Eggers Inga Jansing Kerstin Schilling Anja Erika Hauser Mark Korthals Klaus-Dieter Fischer |
| author_facet |
Kerry Tedford Michael Steiner Stanislav Koshutin Karin Richter Laura Tech Yannik Eggers Inga Jansing Kerstin Schilling Anja Erika Hauser Mark Korthals Klaus-Dieter Fischer |
| author_sort |
Kerry Tedford |
| title |
The opposing forces of shear flow and sphingosine-1-phosphate control marginal zone B cell shuttling |
| title_short |
The opposing forces of shear flow and sphingosine-1-phosphate control marginal zone B cell shuttling |
| title_full |
The opposing forces of shear flow and sphingosine-1-phosphate control marginal zone B cell shuttling |
| title_fullStr |
The opposing forces of shear flow and sphingosine-1-phosphate control marginal zone B cell shuttling |
| title_full_unstemmed |
The opposing forces of shear flow and sphingosine-1-phosphate control marginal zone B cell shuttling |
| title_sort |
opposing forces of shear flow and sphingosine-1-phosphate control marginal zone b cell shuttling |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/4ea3d978a3034f2a94cc0a2735ba5f3c |
| work_keys_str_mv |
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