PINK1-mediated phosphorylation of LETM1 regulates mitochondrial calcium transport and protects neurons against mitochondrial stress

Mutations in the mitochondrial kinase PINK1 result in familial Parkinson’s disease. Here the authors show that LETM1, a mitochondrial inner membrane protein, is a substrate of PINK1 that regulates Ca2+ handling in mitochondria in response to mitochondrial toxins.

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Autores principales:	En Huang, Dianbo Qu, Tianwen Huang, Nicoletta Rizzi, Wassamon Boonying, Dorothy Krolak, Paolo Ciana, John Woulfe, Christine Klein, Ruth S. Slack, Daniel Figeys, David S. Park
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4ea42cdc1afd4b7ba93863559be370d3
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spelling	oai:doaj.org-article:4ea42cdc1afd4b7ba93863559be370d32021-12-02T17:06:08ZPINK1-mediated phosphorylation of LETM1 regulates mitochondrial calcium transport and protects neurons against mitochondrial stress10.1038/s41467-017-01435-12041-1723https://doaj.org/article/4ea42cdc1afd4b7ba93863559be370d32017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01435-1https://doaj.org/toc/2041-1723Mutations in the mitochondrial kinase PINK1 result in familial Parkinson’s disease. Here the authors show that LETM1, a mitochondrial inner membrane protein, is a substrate of PINK1 that regulates Ca2+ handling in mitochondria in response to mitochondrial toxins.En HuangDianbo QuTianwen HuangNicoletta RizziWassamon BoonyingDorothy KrolakPaolo CianaJohn WoulfeChristine KleinRuth S. SlackDaniel FigeysDavid S. ParkNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q En Huang Dianbo Qu Tianwen Huang Nicoletta Rizzi Wassamon Boonying Dorothy Krolak Paolo Ciana John Woulfe Christine Klein Ruth S. Slack Daniel Figeys David S. Park PINK1-mediated phosphorylation of LETM1 regulates mitochondrial calcium transport and protects neurons against mitochondrial stress
description	Mutations in the mitochondrial kinase PINK1 result in familial Parkinson’s disease. Here the authors show that LETM1, a mitochondrial inner membrane protein, is a substrate of PINK1 that regulates Ca2+ handling in mitochondria in response to mitochondrial toxins.
format	article
author	En Huang Dianbo Qu Tianwen Huang Nicoletta Rizzi Wassamon Boonying Dorothy Krolak Paolo Ciana John Woulfe Christine Klein Ruth S. Slack Daniel Figeys David S. Park
author_facet	En Huang Dianbo Qu Tianwen Huang Nicoletta Rizzi Wassamon Boonying Dorothy Krolak Paolo Ciana John Woulfe Christine Klein Ruth S. Slack Daniel Figeys David S. Park
author_sort	En Huang
title	PINK1-mediated phosphorylation of LETM1 regulates mitochondrial calcium transport and protects neurons against mitochondrial stress
title_short	PINK1-mediated phosphorylation of LETM1 regulates mitochondrial calcium transport and protects neurons against mitochondrial stress
title_full	PINK1-mediated phosphorylation of LETM1 regulates mitochondrial calcium transport and protects neurons against mitochondrial stress
title_fullStr	PINK1-mediated phosphorylation of LETM1 regulates mitochondrial calcium transport and protects neurons against mitochondrial stress
title_full_unstemmed	PINK1-mediated phosphorylation of LETM1 regulates mitochondrial calcium transport and protects neurons against mitochondrial stress
title_sort	pink1-mediated phosphorylation of letm1 regulates mitochondrial calcium transport and protects neurons against mitochondrial stress
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/4ea42cdc1afd4b7ba93863559be370d3
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PINK1-mediated phosphorylation of LETM1 regulates mitochondrial calcium transport and protects neurons against mitochondrial stress

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