Interaction between γ-aminobutyric acid A receptor genes: new evidence in migraine susceptibility.

Migraine is a common neurological episodic disorder with a female-to-male prevalence 3- to 4-fold higher, suggesting a possible X-linked genetic component. Our aims were to assess the role of common variants of gamma-aminobutyric acid A receptor (GABAAR) genes, located in the X-chromosome, in migrai...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Marlene Quintas, João Luís Neto, José Pereira-Monteiro, José Barros, Jorge Sequeiros, Alda Sousa, Isabel Alonso, Carolina Lemos
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4ea71118494544e88e01890507ff9ed7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4ea71118494544e88e01890507ff9ed7
record_format	dspace
spelling	oai:doaj.org-article:4ea71118494544e88e01890507ff9ed72021-11-18T08:56:39ZInteraction between γ-aminobutyric acid A receptor genes: new evidence in migraine susceptibility.1932-620310.1371/journal.pone.0074087https://doaj.org/article/4ea71118494544e88e01890507ff9ed72013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24040174/?tool=EBIhttps://doaj.org/toc/1932-6203Migraine is a common neurological episodic disorder with a female-to-male prevalence 3- to 4-fold higher, suggesting a possible X-linked genetic component. Our aims were to assess the role of common variants of gamma-aminobutyric acid A receptor (GABAAR) genes, located in the X-chromosome, in migraine susceptibility and the possible interaction between them. An association study with 188 unrelated cases and 286 migraine-free controls age- and ethnic matched was performed. Twenty-three tagging SNPs were selected in three genes (GABRE, GABRA3 and GABRQ). Allelic, genotypic and haplotypic frequencies were compared between cases and controls. We also focused on gene-gene interactions. The AT genotype of rs3810651 of GABRQ gene was associated with an increased risk for migraine (OR: 4.07; 95% CI: 1.71-9.73, p=0.002), while the CT genotype of rs3902802 (OR: 0.41; 95% CI: 0.21-0.78, p=0.006) and GA genotype of rs2131190 of GABRA3 gene (OR: 0.53; 95% CI: 0.32-0.88, p=0.013) seem to be protective factors. All associations were found in the female group and maintained significance after Bonferroni correction. We also found three nominal associations in the allelic analyses although there were no significant results in the haplotypic analyses. Strikingly, we found strong interactions between six SNPs encoding for different subunits of GABAAR, all significant after permutation correction. To our knowledge, we show for the first time, the putative involvement of polymorphisms in GABAAR genes in migraine susceptibility and more importantly we unraveled a role for novel gene-gene interactions opening new perspectives for the development of more effective treatments.Marlene QuintasJoão Luís NetoJosé Pereira-MonteiroJosé BarrosJorge SequeirosAlda SousaIsabel AlonsoCarolina LemosPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 9, p e74087 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marlene Quintas João Luís Neto José Pereira-Monteiro José Barros Jorge Sequeiros Alda Sousa Isabel Alonso Carolina Lemos Interaction between γ-aminobutyric acid A receptor genes: new evidence in migraine susceptibility.
description	Migraine is a common neurological episodic disorder with a female-to-male prevalence 3- to 4-fold higher, suggesting a possible X-linked genetic component. Our aims were to assess the role of common variants of gamma-aminobutyric acid A receptor (GABAAR) genes, located in the X-chromosome, in migraine susceptibility and the possible interaction between them. An association study with 188 unrelated cases and 286 migraine-free controls age- and ethnic matched was performed. Twenty-three tagging SNPs were selected in three genes (GABRE, GABRA3 and GABRQ). Allelic, genotypic and haplotypic frequencies were compared between cases and controls. We also focused on gene-gene interactions. The AT genotype of rs3810651 of GABRQ gene was associated with an increased risk for migraine (OR: 4.07; 95% CI: 1.71-9.73, p=0.002), while the CT genotype of rs3902802 (OR: 0.41; 95% CI: 0.21-0.78, p=0.006) and GA genotype of rs2131190 of GABRA3 gene (OR: 0.53; 95% CI: 0.32-0.88, p=0.013) seem to be protective factors. All associations were found in the female group and maintained significance after Bonferroni correction. We also found three nominal associations in the allelic analyses although there were no significant results in the haplotypic analyses. Strikingly, we found strong interactions between six SNPs encoding for different subunits of GABAAR, all significant after permutation correction. To our knowledge, we show for the first time, the putative involvement of polymorphisms in GABAAR genes in migraine susceptibility and more importantly we unraveled a role for novel gene-gene interactions opening new perspectives for the development of more effective treatments.
format	article
author	Marlene Quintas João Luís Neto José Pereira-Monteiro José Barros Jorge Sequeiros Alda Sousa Isabel Alonso Carolina Lemos
author_facet	Marlene Quintas João Luís Neto José Pereira-Monteiro José Barros Jorge Sequeiros Alda Sousa Isabel Alonso Carolina Lemos
author_sort	Marlene Quintas
title	Interaction between γ-aminobutyric acid A receptor genes: new evidence in migraine susceptibility.
title_short	Interaction between γ-aminobutyric acid A receptor genes: new evidence in migraine susceptibility.
title_full	Interaction between γ-aminobutyric acid A receptor genes: new evidence in migraine susceptibility.
title_fullStr	Interaction between γ-aminobutyric acid A receptor genes: new evidence in migraine susceptibility.
title_full_unstemmed	Interaction between γ-aminobutyric acid A receptor genes: new evidence in migraine susceptibility.
title_sort	interaction between γ-aminobutyric acid a receptor genes: new evidence in migraine susceptibility.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/4ea71118494544e88e01890507ff9ed7
work_keys_str_mv	AT marlenequintas interactionbetweengaminobutyricacidareceptorgenesnewevidenceinmigrainesusceptibility AT joaoluisneto interactionbetweengaminobutyricacidareceptorgenesnewevidenceinmigrainesusceptibility AT josepereiramonteiro interactionbetweengaminobutyricacidareceptorgenesnewevidenceinmigrainesusceptibility AT josebarros interactionbetweengaminobutyricacidareceptorgenesnewevidenceinmigrainesusceptibility AT jorgesequeiros interactionbetweengaminobutyricacidareceptorgenesnewevidenceinmigrainesusceptibility AT aldasousa interactionbetweengaminobutyricacidareceptorgenesnewevidenceinmigrainesusceptibility AT isabelalonso interactionbetweengaminobutyricacidareceptorgenesnewevidenceinmigrainesusceptibility AT carolinalemos interactionbetweengaminobutyricacidareceptorgenesnewevidenceinmigrainesusceptibility
_version_	1718421139278004224

Interaction between γ-aminobutyric acid A receptor genes: new evidence in migraine susceptibility.

Ejemplares similares