Loss of the molecular clock in myeloid cells exacerbates T cell-mediated CNS autoimmune disease

Circadian controls of immune responses by the molecular clock have been reported, but the underlying mechanisms are unclear. Here the authors show that the master circadian gene, Bmal1, is essential for modulating the homeostasis of myeloid cells to control pro-inflammatory IL-17+/IFN-γ+ T cells in...

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Autores principales:	Caroline E. Sutton, Conor M. Finlay, Mathilde Raverdeau, James O. Early, Joseph DeCourcey, Zbigniew Zaslona, Luke A. J. O’Neill, Kingston H. G. Mills, Annie M. Curtis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4eaabe1ffd9242d6a2d583bbb9b1dc73
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spelling	oai:doaj.org-article:4eaabe1ffd9242d6a2d583bbb9b1dc732021-12-02T17:06:16ZLoss of the molecular clock in myeloid cells exacerbates T cell-mediated CNS autoimmune disease10.1038/s41467-017-02111-02041-1723https://doaj.org/article/4eaabe1ffd9242d6a2d583bbb9b1dc732017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02111-0https://doaj.org/toc/2041-1723Circadian controls of immune responses by the molecular clock have been reported, but the underlying mechanisms are unclear. Here the authors show that the master circadian gene, Bmal1, is essential for modulating the homeostasis of myeloid cells to control pro-inflammatory IL-17+/IFN-γ+ T cells in autoimmunity.Caroline E. SuttonConor M. FinlayMathilde RaverdeauJames O. EarlyJoseph DeCourceyZbigniew ZaslonaLuke A. J. O’NeillKingston H. G. MillsAnnie M. CurtisNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Caroline E. Sutton Conor M. Finlay Mathilde Raverdeau James O. Early Joseph DeCourcey Zbigniew Zaslona Luke A. J. O’Neill Kingston H. G. Mills Annie M. Curtis Loss of the molecular clock in myeloid cells exacerbates T cell-mediated CNS autoimmune disease
description	Circadian controls of immune responses by the molecular clock have been reported, but the underlying mechanisms are unclear. Here the authors show that the master circadian gene, Bmal1, is essential for modulating the homeostasis of myeloid cells to control pro-inflammatory IL-17+/IFN-γ+ T cells in autoimmunity.
format	article
author	Caroline E. Sutton Conor M. Finlay Mathilde Raverdeau James O. Early Joseph DeCourcey Zbigniew Zaslona Luke A. J. O’Neill Kingston H. G. Mills Annie M. Curtis
author_facet	Caroline E. Sutton Conor M. Finlay Mathilde Raverdeau James O. Early Joseph DeCourcey Zbigniew Zaslona Luke A. J. O’Neill Kingston H. G. Mills Annie M. Curtis
author_sort	Caroline E. Sutton
title	Loss of the molecular clock in myeloid cells exacerbates T cell-mediated CNS autoimmune disease
title_short	Loss of the molecular clock in myeloid cells exacerbates T cell-mediated CNS autoimmune disease
title_full	Loss of the molecular clock in myeloid cells exacerbates T cell-mediated CNS autoimmune disease
title_fullStr	Loss of the molecular clock in myeloid cells exacerbates T cell-mediated CNS autoimmune disease
title_full_unstemmed	Loss of the molecular clock in myeloid cells exacerbates T cell-mediated CNS autoimmune disease
title_sort	loss of the molecular clock in myeloid cells exacerbates t cell-mediated cns autoimmune disease
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/4eaabe1ffd9242d6a2d583bbb9b1dc73
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Loss of the molecular clock in myeloid cells exacerbates T cell-mediated CNS autoimmune disease

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