Clinical impact of visually assessed right ventricular dysfunction in patients with septic shock
Abstract We retrospectively analyzed data from the Medical Information Mart for Intensive Care-III critical care database to determine whether visually-assessed right ventricular (RV) dysfunction was associated with clinical outcomes in septic shock patients. Associations between visually-assessed R...
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Nature Portfolio
2021
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oai:doaj.org-article:4eafc880788d44648ecada39de6425c82021-12-02T18:48:09ZClinical impact of visually assessed right ventricular dysfunction in patients with septic shock10.1038/s41598-021-98397-82045-2322https://doaj.org/article/4eafc880788d44648ecada39de6425c82021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98397-8https://doaj.org/toc/2045-2322Abstract We retrospectively analyzed data from the Medical Information Mart for Intensive Care-III critical care database to determine whether visually-assessed right ventricular (RV) dysfunction was associated with clinical outcomes in septic shock patients. Associations between visually-assessed RV dysfunction by echocardiography and in-hospital mortality, lethal arrhythmia, and hemodynamic indicators to determine the prognostic value of RV dysfunction in patients with septic shock were analyzed. Propensity score analysis showed RV dysfunction was associated with increased risk of in-hospital death in patients with septic shock (adjusted odds ratio [OR] 2.15; 95% confidence interval [CI] 1.99–2.32; P < 0.001). In multivariate logistic regression analysis, RV dysfunction was associated with in-hospital death (OR 2.19; 95% CI 1.91–2.53; P < 0.001), lethal arrhythmia (OR 2.19; 95% CI 1.34–3.57; P < 0.001), and tendency for increased blood lactate levels (OR 1.31; 95% CI 1.14–1.50; P < 0.001) independent of left ventricular (LV) dysfunction. RV dysfunction was associated with lower cardiac output, pulmonary artery pressure index, and RV stroke work index. In patients with septic shock, visually-assessed RV dysfunction was associated with in-hospital mortality, lethal arrhythmia, and circulatory insufficiency independent of LV dysfunction. Visual assessment of RV dysfunction using echocardiography might help to identify the short-term prognosis of patients with septic shock by reflecting hemodynamic status.Hiroaki HiraiwaDaisuke KasugaiMasayuki OzakiYukari GotoNaruhiro JingushiMichiko HigashiKazuki NishidaToru KondoKenji FurusawaRyota MorimotoTakahiro OkumuraNaoyuki MatsudaShigeyuki MatsuiToyoaki MuroharaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021) |
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DOAJ |
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DOAJ |
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Medicine R Science Q |
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Medicine R Science Q Hiroaki Hiraiwa Daisuke Kasugai Masayuki Ozaki Yukari Goto Naruhiro Jingushi Michiko Higashi Kazuki Nishida Toru Kondo Kenji Furusawa Ryota Morimoto Takahiro Okumura Naoyuki Matsuda Shigeyuki Matsui Toyoaki Murohara Clinical impact of visually assessed right ventricular dysfunction in patients with septic shock |
| description |
Abstract We retrospectively analyzed data from the Medical Information Mart for Intensive Care-III critical care database to determine whether visually-assessed right ventricular (RV) dysfunction was associated with clinical outcomes in septic shock patients. Associations between visually-assessed RV dysfunction by echocardiography and in-hospital mortality, lethal arrhythmia, and hemodynamic indicators to determine the prognostic value of RV dysfunction in patients with septic shock were analyzed. Propensity score analysis showed RV dysfunction was associated with increased risk of in-hospital death in patients with septic shock (adjusted odds ratio [OR] 2.15; 95% confidence interval [CI] 1.99–2.32; P < 0.001). In multivariate logistic regression analysis, RV dysfunction was associated with in-hospital death (OR 2.19; 95% CI 1.91–2.53; P < 0.001), lethal arrhythmia (OR 2.19; 95% CI 1.34–3.57; P < 0.001), and tendency for increased blood lactate levels (OR 1.31; 95% CI 1.14–1.50; P < 0.001) independent of left ventricular (LV) dysfunction. RV dysfunction was associated with lower cardiac output, pulmonary artery pressure index, and RV stroke work index. In patients with septic shock, visually-assessed RV dysfunction was associated with in-hospital mortality, lethal arrhythmia, and circulatory insufficiency independent of LV dysfunction. Visual assessment of RV dysfunction using echocardiography might help to identify the short-term prognosis of patients with septic shock by reflecting hemodynamic status. |
| format |
article |
| author |
Hiroaki Hiraiwa Daisuke Kasugai Masayuki Ozaki Yukari Goto Naruhiro Jingushi Michiko Higashi Kazuki Nishida Toru Kondo Kenji Furusawa Ryota Morimoto Takahiro Okumura Naoyuki Matsuda Shigeyuki Matsui Toyoaki Murohara |
| author_facet |
Hiroaki Hiraiwa Daisuke Kasugai Masayuki Ozaki Yukari Goto Naruhiro Jingushi Michiko Higashi Kazuki Nishida Toru Kondo Kenji Furusawa Ryota Morimoto Takahiro Okumura Naoyuki Matsuda Shigeyuki Matsui Toyoaki Murohara |
| author_sort |
Hiroaki Hiraiwa |
| title |
Clinical impact of visually assessed right ventricular dysfunction in patients with septic shock |
| title_short |
Clinical impact of visually assessed right ventricular dysfunction in patients with septic shock |
| title_full |
Clinical impact of visually assessed right ventricular dysfunction in patients with septic shock |
| title_fullStr |
Clinical impact of visually assessed right ventricular dysfunction in patients with septic shock |
| title_full_unstemmed |
Clinical impact of visually assessed right ventricular dysfunction in patients with septic shock |
| title_sort |
clinical impact of visually assessed right ventricular dysfunction in patients with septic shock |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/4eafc880788d44648ecada39de6425c8 |
| work_keys_str_mv |
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