Schwann cells differentiated from skin-derived precursors provide neuroprotection via autophagy inhibition in a cellular model of Parkinson’s disease

Schwann cells differentiated from skin-derived precursors provide neuroprotection via autophagy inhibition in a cellular model of Parkinson’s disease

Autophagy has been shown to play an important role in Parkinson’s disease. We hypothesized that skin-derived precursor cells exhibit neuroprotective effects in Parkinson’s disease through affecting autophagy. In this study, 6-hydroxydopamine-damaged SH-SY5Y cells were pretreated with a culture mediu...

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Autores principales: Jia-Nan Yan, Hai-Ying Zhang, Jun-Rui Li, Ying Chen, Yong-Cheng Jiang, Jia-Bing Shen, Kai-Fu Ke, Xiao-Su Gu
Formato: article
Lenguaje:EN
Publicado: Wolters Kluwer Medknow Publications 2022
Materias:
alpha-synuclein; autophagosomes; autophagy; neural regeneration; neuroprotection; parkinson′s disease; pi3k/akt/mtor pathway; skin-derived precursor schwann cells
Neurology. Diseases of the nervous system
RC346-429
Acceso en línea:https://doaj.org/article/4eb2331ff0b84061875ba3822553891b
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