Feeding with poly(I:C) induced long-term immune responses against bacterial infection in turbot (Scophthalmus maximus)

Poly(I:C) is a kind of chemosynthetic double-stranded RNA (dsRNA) analogue which could act as TLR3 agonist and induce IFN production. It is widely applied in anti-virus treatment and immunoregulation, as well as vaccine adjuvant in farmed animals. However, whether poly(I:C) could activate innate imm...

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Autores principales:	Jing He, Zhuang Wang, Yanbo Zhao, Jin Yang, Yuanxing Zhang, Qin Liu, Dahai Yang
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Poly(I:C) Anti-oxidant stress Intestinal immune responses Bacterial-infection turbot Zoology QL1-991
Acceso en línea:	https://doaj.org/article/4eb4de626f6f41a38e98bd3414e523fe
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spelling	oai:doaj.org-article:4eb4de626f6f41a38e98bd3414e523fe2021-11-26T04:42:30ZFeeding with poly(I:C) induced long-term immune responses against bacterial infection in turbot (Scophthalmus maximus)2667-011910.1016/j.fsirep.2021.100037https://doaj.org/article/4eb4de626f6f41a38e98bd3414e523fe2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2667011921000323https://doaj.org/toc/2667-0119Poly(I:C) is a kind of chemosynthetic double-stranded RNA (dsRNA) analogue which could act as TLR3 agonist and induce IFN production. It is widely applied in anti-virus treatment and immunoregulation, as well as vaccine adjuvant in farmed animals. However, whether poly(I:C) could activate innate immune response to defense against bacterial infection remains unclear. In this study, we established a feeding trial model with different dose of poly(I:C) in turbot larvae, then challenged with Edwardsiella piscicida after 3–7 weeks resting period. The results show that feeding turbot with poly(I:C) exhibited a stronger inflammatory response and antioxidant stress ability, and significantly elevated the survival rate within the decreased bacterial loads. Importantly, the bacterial infection-induced white feces in hindgut of turbot were significantly alleviated after poly(I:C) feeding, and this administration induced protection could last for about 7 weeks. Taken together, these findings indicate that feeding turbot with poly(I:C) could enhance a long-term intestinal mucosal immunity in response to bacterial infection, suggesting that poly(I:C) might be a promising immunostimulant in aquaculture.Jing HeZhuang WangYanbo ZhaoJin YangYuanxing ZhangQin LiuDahai YangElsevierarticlePoly(I:C)Anti-oxidant stressIntestinal immune responsesBacterial-infectionturbotZoologyQL1-991ENFish and Shellfish Immunology Reports, Vol 2, Iss , Pp 100037- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Poly(I:C) Anti-oxidant stress Intestinal immune responses Bacterial-infection turbot Zoology QL1-991
spellingShingle	Poly(I:C) Anti-oxidant stress Intestinal immune responses Bacterial-infection turbot Zoology QL1-991 Jing He Zhuang Wang Yanbo Zhao Jin Yang Yuanxing Zhang Qin Liu Dahai Yang Feeding with poly(I:C) induced long-term immune responses against bacterial infection in turbot (Scophthalmus maximus)
description	Poly(I:C) is a kind of chemosynthetic double-stranded RNA (dsRNA) analogue which could act as TLR3 agonist and induce IFN production. It is widely applied in anti-virus treatment and immunoregulation, as well as vaccine adjuvant in farmed animals. However, whether poly(I:C) could activate innate immune response to defense against bacterial infection remains unclear. In this study, we established a feeding trial model with different dose of poly(I:C) in turbot larvae, then challenged with Edwardsiella piscicida after 3–7 weeks resting period. The results show that feeding turbot with poly(I:C) exhibited a stronger inflammatory response and antioxidant stress ability, and significantly elevated the survival rate within the decreased bacterial loads. Importantly, the bacterial infection-induced white feces in hindgut of turbot were significantly alleviated after poly(I:C) feeding, and this administration induced protection could last for about 7 weeks. Taken together, these findings indicate that feeding turbot with poly(I:C) could enhance a long-term intestinal mucosal immunity in response to bacterial infection, suggesting that poly(I:C) might be a promising immunostimulant in aquaculture.
format	article
author	Jing He Zhuang Wang Yanbo Zhao Jin Yang Yuanxing Zhang Qin Liu Dahai Yang
author_facet	Jing He Zhuang Wang Yanbo Zhao Jin Yang Yuanxing Zhang Qin Liu Dahai Yang
author_sort	Jing He
title	Feeding with poly(I:C) induced long-term immune responses against bacterial infection in turbot (Scophthalmus maximus)
title_short	Feeding with poly(I:C) induced long-term immune responses against bacterial infection in turbot (Scophthalmus maximus)
title_full	Feeding with poly(I:C) induced long-term immune responses against bacterial infection in turbot (Scophthalmus maximus)
title_fullStr	Feeding with poly(I:C) induced long-term immune responses against bacterial infection in turbot (Scophthalmus maximus)
title_full_unstemmed	Feeding with poly(I:C) induced long-term immune responses against bacterial infection in turbot (Scophthalmus maximus)
title_sort	feeding with poly(i:c) induced long-term immune responses against bacterial infection in turbot (scophthalmus maximus)
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/4eb4de626f6f41a38e98bd3414e523fe
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_version_	1718409774678147072

Feeding with poly(I:C) induced long-term immune responses against bacterial infection in turbot (Scophthalmus maximus)

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