Mitochondria in Focus: From Function to Therapeutic Strategies in Chronic Lung Diseases

Mitochondria are essential organelles for cell metabolism, growth, and function. Mitochondria in lung cells have important roles in regulating surfactant production, mucociliary function, mucus secretion, senescence, immunologic defense, and regeneration. Disruption in mitochondrial physiology can b...

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Autores principales:	Dayene de Assis Fernandes Caldeira, Daniel J. Weiss, Patricia Rieken Macêdo Rocco, Pedro Leme Silva, Fernanda Ferreira Cruz
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	mitochondrial dysfunction mitochondrial dynamics mitochondrial morphology mitotherapy chronic lung diseases reactive species of oxygen (ROS) Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/4eb574253ca04174a92ea56a74892887
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spelling	oai:doaj.org-article:4eb574253ca04174a92ea56a748928872021-11-30T12:16:17ZMitochondria in Focus: From Function to Therapeutic Strategies in Chronic Lung Diseases1664-322410.3389/fimmu.2021.782074https://doaj.org/article/4eb574253ca04174a92ea56a748928872021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.782074/fullhttps://doaj.org/toc/1664-3224Mitochondria are essential organelles for cell metabolism, growth, and function. Mitochondria in lung cells have important roles in regulating surfactant production, mucociliary function, mucus secretion, senescence, immunologic defense, and regeneration. Disruption in mitochondrial physiology can be the central point in several pathophysiologic pathways of chronic lung diseases such as chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, and asthma. In this review, we summarize how mitochondria morphology, dynamics, redox signaling, mitophagy, and interaction with the endoplasmic reticulum are involved in chronic lung diseases and highlight strategies focused on mitochondrial therapy (mito-therapy) that could be tested as a potential therapeutic target for lung diseases.Dayene de Assis Fernandes CaldeiraDaniel J. WeissPatricia Rieken Macêdo RoccoPatricia Rieken Macêdo RoccoPatricia Rieken Macêdo RoccoPedro Leme SilvaPedro Leme SilvaPedro Leme SilvaFernanda Ferreira CruzFernanda Ferreira CruzFernanda Ferreira CruzFrontiers Media S.A.articlemitochondrial dysfunctionmitochondrial dynamicsmitochondrial morphologymitotherapychronic lung diseasesreactive species of oxygen (ROS)Immunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	mitochondrial dysfunction mitochondrial dynamics mitochondrial morphology mitotherapy chronic lung diseases reactive species of oxygen (ROS) Immunologic diseases. Allergy RC581-607
spellingShingle	mitochondrial dysfunction mitochondrial dynamics mitochondrial morphology mitotherapy chronic lung diseases reactive species of oxygen (ROS) Immunologic diseases. Allergy RC581-607 Dayene de Assis Fernandes Caldeira Daniel J. Weiss Patricia Rieken Macêdo Rocco Patricia Rieken Macêdo Rocco Patricia Rieken Macêdo Rocco Pedro Leme Silva Pedro Leme Silva Pedro Leme Silva Fernanda Ferreira Cruz Fernanda Ferreira Cruz Fernanda Ferreira Cruz Mitochondria in Focus: From Function to Therapeutic Strategies in Chronic Lung Diseases
description	Mitochondria are essential organelles for cell metabolism, growth, and function. Mitochondria in lung cells have important roles in regulating surfactant production, mucociliary function, mucus secretion, senescence, immunologic defense, and regeneration. Disruption in mitochondrial physiology can be the central point in several pathophysiologic pathways of chronic lung diseases such as chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, and asthma. In this review, we summarize how mitochondria morphology, dynamics, redox signaling, mitophagy, and interaction with the endoplasmic reticulum are involved in chronic lung diseases and highlight strategies focused on mitochondrial therapy (mito-therapy) that could be tested as a potential therapeutic target for lung diseases.
format	article
author	Dayene de Assis Fernandes Caldeira Daniel J. Weiss Patricia Rieken Macêdo Rocco Patricia Rieken Macêdo Rocco Patricia Rieken Macêdo Rocco Pedro Leme Silva Pedro Leme Silva Pedro Leme Silva Fernanda Ferreira Cruz Fernanda Ferreira Cruz Fernanda Ferreira Cruz
author_facet	Dayene de Assis Fernandes Caldeira Daniel J. Weiss Patricia Rieken Macêdo Rocco Patricia Rieken Macêdo Rocco Patricia Rieken Macêdo Rocco Pedro Leme Silva Pedro Leme Silva Pedro Leme Silva Fernanda Ferreira Cruz Fernanda Ferreira Cruz Fernanda Ferreira Cruz
author_sort	Dayene de Assis Fernandes Caldeira
title	Mitochondria in Focus: From Function to Therapeutic Strategies in Chronic Lung Diseases
title_short	Mitochondria in Focus: From Function to Therapeutic Strategies in Chronic Lung Diseases
title_full	Mitochondria in Focus: From Function to Therapeutic Strategies in Chronic Lung Diseases
title_fullStr	Mitochondria in Focus: From Function to Therapeutic Strategies in Chronic Lung Diseases
title_full_unstemmed	Mitochondria in Focus: From Function to Therapeutic Strategies in Chronic Lung Diseases
title_sort	mitochondria in focus: from function to therapeutic strategies in chronic lung diseases
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/4eb574253ca04174a92ea56a74892887
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Mitochondria in Focus: From Function to Therapeutic Strategies in Chronic Lung Diseases

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