Intraspecies and interspecies transmission of mink H9N2 influenza virus

Abstract H9N2 influenza A virus (IAV) causes low pathogenic respiratory disease and infects a wide range of hosts. In this study, six IAVs were isolated from mink and identified as H9N2 IAV. Sequence analysis revealed that the six isolates continued to evolve, and their PB2 genes shared high nucleot...

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Autores principales:	Zhao Yong-feng, Diao Fei-fei, Yu Jia-yu, Zhang Feng-xia, Jiang Chang-qing, Wang Jian-li, Guo Shou-yu, Cui Kai, Liu Chuan-yi, Wei Xue-hua, Shi-jin Jiang, Xie Zhi-jing
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4eb909e575894876aa47f2fc0af1d23f
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spelling	oai:doaj.org-article:4eb909e575894876aa47f2fc0af1d23f2021-12-02T16:06:46ZIntraspecies and interspecies transmission of mink H9N2 influenza virus10.1038/s41598-017-07879-12045-2322https://doaj.org/article/4eb909e575894876aa47f2fc0af1d23f2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07879-1https://doaj.org/toc/2045-2322Abstract H9N2 influenza A virus (IAV) causes low pathogenic respiratory disease and infects a wide range of hosts. In this study, six IAVs were isolated from mink and identified as H9N2 IAV. Sequence analysis revealed that the six isolates continued to evolve, and their PB2 genes shared high nucleotide sequence identity with H7N9 IAV. The six isolates contained an amino acid motif PSRSSR↓GL at the hemagglutinin cleavage site, which is a characteristic of low pathogenic influenza viruses. A serosurvey demonstrated that H9N2 IAV had spread widely in mink and was prevalent in foxes and raccoon dogs. Transmission experiments showed that close contact between H9N2-infected mink and naive mink, foxes and raccoon dogs resulted in spread of the virus to the contact animals. Furthermore, H9N2 challenge experiments in foxes and raccoon dogs showed that H9N2 IAV could infect these hosts. Virological and epidemiological surveillance of H9N2 IAV should be strengthened for the fur animal industry.Zhao Yong-fengDiao Fei-feiYu Jia-yuZhang Feng-xiaJiang Chang-qingWang Jian-liGuo Shou-yuCui KaiLiu Chuan-yiWei Xue-huaShi-jin JiangXie Zhi-jingNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zhao Yong-feng Diao Fei-fei Yu Jia-yu Zhang Feng-xia Jiang Chang-qing Wang Jian-li Guo Shou-yu Cui Kai Liu Chuan-yi Wei Xue-hua Shi-jin Jiang Xie Zhi-jing Intraspecies and interspecies transmission of mink H9N2 influenza virus
description	Abstract H9N2 influenza A virus (IAV) causes low pathogenic respiratory disease and infects a wide range of hosts. In this study, six IAVs were isolated from mink and identified as H9N2 IAV. Sequence analysis revealed that the six isolates continued to evolve, and their PB2 genes shared high nucleotide sequence identity with H7N9 IAV. The six isolates contained an amino acid motif PSRSSR↓GL at the hemagglutinin cleavage site, which is a characteristic of low pathogenic influenza viruses. A serosurvey demonstrated that H9N2 IAV had spread widely in mink and was prevalent in foxes and raccoon dogs. Transmission experiments showed that close contact between H9N2-infected mink and naive mink, foxes and raccoon dogs resulted in spread of the virus to the contact animals. Furthermore, H9N2 challenge experiments in foxes and raccoon dogs showed that H9N2 IAV could infect these hosts. Virological and epidemiological surveillance of H9N2 IAV should be strengthened for the fur animal industry.
format	article
author	Zhao Yong-feng Diao Fei-fei Yu Jia-yu Zhang Feng-xia Jiang Chang-qing Wang Jian-li Guo Shou-yu Cui Kai Liu Chuan-yi Wei Xue-hua Shi-jin Jiang Xie Zhi-jing
author_facet	Zhao Yong-feng Diao Fei-fei Yu Jia-yu Zhang Feng-xia Jiang Chang-qing Wang Jian-li Guo Shou-yu Cui Kai Liu Chuan-yi Wei Xue-hua Shi-jin Jiang Xie Zhi-jing
author_sort	Zhao Yong-feng
title	Intraspecies and interspecies transmission of mink H9N2 influenza virus
title_short	Intraspecies and interspecies transmission of mink H9N2 influenza virus
title_full	Intraspecies and interspecies transmission of mink H9N2 influenza virus
title_fullStr	Intraspecies and interspecies transmission of mink H9N2 influenza virus
title_full_unstemmed	Intraspecies and interspecies transmission of mink H9N2 influenza virus
title_sort	intraspecies and interspecies transmission of mink h9n2 influenza virus
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/4eb909e575894876aa47f2fc0af1d23f
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Intraspecies and interspecies transmission of mink H9N2 influenza virus

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