Expression of the Ebola Virus VP24 Protein Compromises the Integrity of the Nuclear Envelope and Induces a Laminopathy-Like Cellular Phenotype

Expression of the Ebola Virus VP24 Protein Compromises the Integrity of the Nuclear Envelope and Induces a Laminopathy-Like Cellular Phenotype

ABSTRACT Ebola virus (EBOV) VP24 protein is a nucleocapsid-associated protein that inhibits interferon (IFN) gene expression and counteracts the IFN-mediated antiviral response, preventing nuclear import of signal transducer and activator of transcription 1 (STAT1). Proteomic studies to identify add...

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Main Authors: Santiago Vidal, Maite Sánchez-Aparicio, Rocío Seoane, Ahmed El Motiam, Emily V. Nelson, Yanis H. Bouzaher, Maite Baz-Martínez, Isabel García-Dorival, Susana Gonzalo, Enrique Vázquez, Anxo Vidal, César Muñoz-Fontela, Adolfo García-Sastre, Carmen Rivas
Format: article
Language:EN
Published: American Society for Microbiology 2021
Subjects:
Ebola virus
laminopathies
nuclear envelope
virus-host interactions
Microbiology
QR1-502
Online Access:https://doaj.org/article/4ebc5e9dbfd7490c8149d9b1444d153f
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https://doaj.org/article/4ebc5e9dbfd7490c8149d9b1444d153f

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