The impact of structural and functional parameters in glaucoma patients on patient-reported visual functioning.

<h4>Background</h4>To evaluate the impact of structural changes of the retinal nerve fiber layer (RNFL), and visual field loss, on functional impairment assessed by patient-reported visual functioning in glaucoma.<h4>Methods</h4>Patients with glaucomatous optic nerve damage w...

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Autores principales:	Christoph Hirneiß, Lukas Reznicek, Michaela Vogel, Konrad Pesudovs
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4ebcff464a8a49f2a7895985c673c027
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spelling	oai:doaj.org-article:4ebcff464a8a49f2a7895985c673c0272021-11-18T08:43:48ZThe impact of structural and functional parameters in glaucoma patients on patient-reported visual functioning.1932-620310.1371/journal.pone.0080757https://doaj.org/article/4ebcff464a8a49f2a7895985c673c0272013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24312500/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>To evaluate the impact of structural changes of the retinal nerve fiber layer (RNFL), and visual field loss, on functional impairment assessed by patient-reported visual functioning in glaucoma.<h4>Methods</h4>Patients with glaucomatous optic nerve damage were enrolled in this cross-sectional study. Peripapillary RNFL thickness was obtained with spectral-domain optical coherence tomography (SD-OCT). Function was assessed by patient-reported visual functioning using the Rasch-calibrated Glaucoma Activity Limitation 9 (GAL-9) questionnaire and standard automated perimetry. The impact of peripapillary RNFL loss on functional impairment was analyzed with correlation and linear regression analyses.<h4>Results</h4>A total of 176 eyes from 88 glaucoma patients were included. The SD-OCT assessed temporal-superior and temporal-inferior RNFL sector of the worse eye revealed significant correlation with the GAL-9 scores (r=-0.298, p=0.011 and r=-0.251, p=0.033, respectively). In mutivariate regression analysis, the best predictors for patient-reported visual functioning were visual acuity of the better eye and mean defect of the worse eye (R(2)=0.334), while structural parameters could not enhance the prediction of GAL-9 scores.<h4>Conclusions</h4>Self-reported visual functioning of patients with glaucoma is better predicted by visual performance data than structural parameters. However, some structural changes of the worse eye are significantly correlated with patient-reported visual functioning.Christoph HirneißLukas ReznicekMichaela VogelKonrad PesudovsPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 12, p e80757 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Christoph Hirneiß Lukas Reznicek Michaela Vogel Konrad Pesudovs The impact of structural and functional parameters in glaucoma patients on patient-reported visual functioning.
description	<h4>Background</h4>To evaluate the impact of structural changes of the retinal nerve fiber layer (RNFL), and visual field loss, on functional impairment assessed by patient-reported visual functioning in glaucoma.<h4>Methods</h4>Patients with glaucomatous optic nerve damage were enrolled in this cross-sectional study. Peripapillary RNFL thickness was obtained with spectral-domain optical coherence tomography (SD-OCT). Function was assessed by patient-reported visual functioning using the Rasch-calibrated Glaucoma Activity Limitation 9 (GAL-9) questionnaire and standard automated perimetry. The impact of peripapillary RNFL loss on functional impairment was analyzed with correlation and linear regression analyses.<h4>Results</h4>A total of 176 eyes from 88 glaucoma patients were included. The SD-OCT assessed temporal-superior and temporal-inferior RNFL sector of the worse eye revealed significant correlation with the GAL-9 scores (r=-0.298, p=0.011 and r=-0.251, p=0.033, respectively). In mutivariate regression analysis, the best predictors for patient-reported visual functioning were visual acuity of the better eye and mean defect of the worse eye (R(2)=0.334), while structural parameters could not enhance the prediction of GAL-9 scores.<h4>Conclusions</h4>Self-reported visual functioning of patients with glaucoma is better predicted by visual performance data than structural parameters. However, some structural changes of the worse eye are significantly correlated with patient-reported visual functioning.
format	article
author	Christoph Hirneiß Lukas Reznicek Michaela Vogel Konrad Pesudovs
author_facet	Christoph Hirneiß Lukas Reznicek Michaela Vogel Konrad Pesudovs
author_sort	Christoph Hirneiß
title	The impact of structural and functional parameters in glaucoma patients on patient-reported visual functioning.
title_short	The impact of structural and functional parameters in glaucoma patients on patient-reported visual functioning.
title_full	The impact of structural and functional parameters in glaucoma patients on patient-reported visual functioning.
title_fullStr	The impact of structural and functional parameters in glaucoma patients on patient-reported visual functioning.
title_full_unstemmed	The impact of structural and functional parameters in glaucoma patients on patient-reported visual functioning.
title_sort	impact of structural and functional parameters in glaucoma patients on patient-reported visual functioning.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/4ebcff464a8a49f2a7895985c673c027
work_keys_str_mv	AT christophhirneiß theimpactofstructuralandfunctionalparametersinglaucomapatientsonpatientreportedvisualfunctioning AT lukasreznicek theimpactofstructuralandfunctionalparametersinglaucomapatientsonpatientreportedvisualfunctioning AT michaelavogel theimpactofstructuralandfunctionalparametersinglaucomapatientsonpatientreportedvisualfunctioning AT konradpesudovs theimpactofstructuralandfunctionalparametersinglaucomapatientsonpatientreportedvisualfunctioning AT christophhirneiß impactofstructuralandfunctionalparametersinglaucomapatientsonpatientreportedvisualfunctioning AT lukasreznicek impactofstructuralandfunctionalparametersinglaucomapatientsonpatientreportedvisualfunctioning AT michaelavogel impactofstructuralandfunctionalparametersinglaucomapatientsonpatientreportedvisualfunctioning AT konradpesudovs impactofstructuralandfunctionalparametersinglaucomapatientsonpatientreportedvisualfunctioning
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The impact of structural and functional parameters in glaucoma patients on patient-reported visual functioning.

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