Time and metabolic state-dependent effects of GLP-1R agonists on NPY/AgRP and POMC neuronal activity in vivo

Time and metabolic state-dependent effects of GLP-1R agonists on NPY/AgRP and POMC neuronal activity in vivo

Objective: Long-acting glucagon-like peptide-1 receptor agonists (GLP-1RAs), like liraglutide and semaglutide, are viable treatments for diabetes and obesity. Liraglutide directly activates hypothalamic proopiomelanocortin (POMC) neurons while indirectly inhibiting Neuropeptide Y/Agouti-related pept...

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Bibliographic Details
Main Authors: Yanbin Dong, Jamie Carty, Nitsan Goldstein, Zhenyan He, Eunsang Hwang, Dominic Chau, Briana Wallace, Anita Kabahizi, Linh Lieu, Yunqian Peng, Yong Gao, Ling Hu, J. Nicholas Betley, Kevin W. Williams
Format: article
Language:EN
Published: Elsevier 2021
Subjects:
Liraglutide and semaglutide
Long-acting glucagon-like peptide-1 receptor agonists (GLP-1RAs)
TRPC5 subunit
Metabolic state-dependent effects
GLP-1R Agonists on NPY/AgRP neuron
POMC Neuronal activity
Internal medicine
RC31-1245
Online Access:https://doaj.org/article/4ec2aa488f164583b0cbb499e20a9df9
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