Dorsal raphe serotonin neurotransmission is required for the expression of nursing behavior and for pup survival

Abstract Proper maternal care is an essential factor of reproductive success in mammals, involving a repertoire of behaviors oriented toward the feeding and care of the offspring. Among the neurotransmitters involved in the initiation of these behaviors, serotonin (5-HT) seems to play an important r...

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Autores principales:	Aude Muzerelle, Mariano Soiza-Reilly, Cornelia Hainer, Pierre-Louis Ruet, Klaus-Peter Lesch, Michael Bader, Natalia Alenina, Sophie Scotto-Lomassese, Patricia Gaspar
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4ec7ccf69be14af68c79ac01c94cc2f6
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spelling	oai:doaj.org-article:4ec7ccf69be14af68c79ac01c94cc2f62021-12-02T17:05:01ZDorsal raphe serotonin neurotransmission is required for the expression of nursing behavior and for pup survival10.1038/s41598-021-84368-62045-2322https://doaj.org/article/4ec7ccf69be14af68c79ac01c94cc2f62021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84368-6https://doaj.org/toc/2045-2322Abstract Proper maternal care is an essential factor of reproductive success in mammals, involving a repertoire of behaviors oriented toward the feeding and care of the offspring. Among the neurotransmitters involved in the initiation of these behaviors, serotonin (5-HT) seems to play an important role. Here we compared pup-oriented maternal behaviors in mice with constitutive 5-HT depletion, the tryptophan hydroxylase 2-knock-out (Tph2-KO) and the Pet1-KO mice. We report that the only common pup-oriented defect in these 2 hyposerotoninergic models is a defective nursing in parturient mice and altered nursing-like (crouching) behavior in virgin mice, while pup retrieval defects are only present in Tph2-KO. Despite a normal mammary gland development and milk production, the defect in appropriate nursing is responsible for severe growth retardation and early lethality of pups born to hyposerotonergic dams. This nursing defect is due to acute rather constitutive 5-HT depletion, as it is reproduced by adult knockdown of Tph2 in the dorsal raphe nucleus in mothers with a prior normal maternal experience. We conclude that 5-HT innervation from the dorsal raphe is required for both the initiation and maintenance of a normal nursing behavior. Our findings may be related to observations of reduced maternal/infant interactions in human depression.Aude MuzerelleMariano Soiza-ReillyCornelia HainerPierre-Louis RuetKlaus-Peter LeschMichael BaderNatalia AleninaSophie Scotto-LomassesePatricia GasparNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Aude Muzerelle Mariano Soiza-Reilly Cornelia Hainer Pierre-Louis Ruet Klaus-Peter Lesch Michael Bader Natalia Alenina Sophie Scotto-Lomassese Patricia Gaspar Dorsal raphe serotonin neurotransmission is required for the expression of nursing behavior and for pup survival
description	Abstract Proper maternal care is an essential factor of reproductive success in mammals, involving a repertoire of behaviors oriented toward the feeding and care of the offspring. Among the neurotransmitters involved in the initiation of these behaviors, serotonin (5-HT) seems to play an important role. Here we compared pup-oriented maternal behaviors in mice with constitutive 5-HT depletion, the tryptophan hydroxylase 2-knock-out (Tph2-KO) and the Pet1-KO mice. We report that the only common pup-oriented defect in these 2 hyposerotoninergic models is a defective nursing in parturient mice and altered nursing-like (crouching) behavior in virgin mice, while pup retrieval defects are only present in Tph2-KO. Despite a normal mammary gland development and milk production, the defect in appropriate nursing is responsible for severe growth retardation and early lethality of pups born to hyposerotonergic dams. This nursing defect is due to acute rather constitutive 5-HT depletion, as it is reproduced by adult knockdown of Tph2 in the dorsal raphe nucleus in mothers with a prior normal maternal experience. We conclude that 5-HT innervation from the dorsal raphe is required for both the initiation and maintenance of a normal nursing behavior. Our findings may be related to observations of reduced maternal/infant interactions in human depression.
format	article
author	Aude Muzerelle Mariano Soiza-Reilly Cornelia Hainer Pierre-Louis Ruet Klaus-Peter Lesch Michael Bader Natalia Alenina Sophie Scotto-Lomassese Patricia Gaspar
author_facet	Aude Muzerelle Mariano Soiza-Reilly Cornelia Hainer Pierre-Louis Ruet Klaus-Peter Lesch Michael Bader Natalia Alenina Sophie Scotto-Lomassese Patricia Gaspar
author_sort	Aude Muzerelle
title	Dorsal raphe serotonin neurotransmission is required for the expression of nursing behavior and for pup survival
title_short	Dorsal raphe serotonin neurotransmission is required for the expression of nursing behavior and for pup survival
title_full	Dorsal raphe serotonin neurotransmission is required for the expression of nursing behavior and for pup survival
title_fullStr	Dorsal raphe serotonin neurotransmission is required for the expression of nursing behavior and for pup survival
title_full_unstemmed	Dorsal raphe serotonin neurotransmission is required for the expression of nursing behavior and for pup survival
title_sort	dorsal raphe serotonin neurotransmission is required for the expression of nursing behavior and for pup survival
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4ec7ccf69be14af68c79ac01c94cc2f6
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Dorsal raphe serotonin neurotransmission is required for the expression of nursing behavior and for pup survival

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