Epidemiology of candidemia in Latin America: a laboratory-based survey.

<h4>Background</h4>The epidemiology of candidemia varies depending on the geographic region. Little is known about the epidemiology of candidemia in Latin America.<h4>Methods</h4>We conducted a 24-month laboratory-based survey of candidemia in 20 centers of seven Latin Americ...

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Autores principales:	Marcio Nucci, Flavio Queiroz-Telles, Tito Alvarado-Matute, Iris Nora Tiraboschi, Jorge Cortes, Jeannete Zurita, Manuel Guzman-Blanco, Maria Elena Santolaya, Luis Thompson, Jose Sifuentes-Osornio, Juan I Echevarria, Arnaldo L Colombo, Latin American Invasive Mycosis Network
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4ec7e0fc917b496183fa5a630f9deebd
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spelling	oai:doaj.org-article:4ec7e0fc917b496183fa5a630f9deebd2021-11-18T07:52:51ZEpidemiology of candidemia in Latin America: a laboratory-based survey.1932-620310.1371/journal.pone.0059373https://doaj.org/article/4ec7e0fc917b496183fa5a630f9deebd2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23527176/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>The epidemiology of candidemia varies depending on the geographic region. Little is known about the epidemiology of candidemia in Latin America.<h4>Methods</h4>We conducted a 24-month laboratory-based survey of candidemia in 20 centers of seven Latin American countries. Incidence rates were calculated and the epidemiology of candidemia was characterized.<h4>Results</h4>Among 672 episodes of candidemia, 297 (44.2%) occurred in children (23.7% younger than 1 year), 36.2% in adults between 19 and 60 years old and 19.6% in elderly patients. The overall incidence was 1.18 cases per 1,000 admissions, and varied across countries, with the highest incidence in Colombia and the lowest in Chile. Candida albicans (37.6%), C. parapsilosis (26.5%) and C. tropicalis (17.6%) were the leading agents, with great variability in species distribution in the different countries. Most isolates were highly susceptible to fluconazole, voriconazole, amphotericin B and anidulafungin. Fluconazole was the most frequent agent used as primary treatment (65.8%), and the overall 30-day survival was 59.3%.<h4>Conclusions</h4>This first large epidemiologic study of candidemia in Latin America showed a high incidence of candidemia, high percentage of children, typical species distribution, with C. albicans, C. parapsilosis and C. tropicalis accounting for the majority of episodes, and low resistance rates.Marcio NucciFlavio Queiroz-TellesTito Alvarado-MatuteIris Nora TiraboschiJorge CortesJeannete ZuritaManuel Guzman-BlancoMaria Elena SantolayaLuis ThompsonJose Sifuentes-OsornioJuan I EchevarriaArnaldo L ColomboLatin American Invasive Mycosis NetworkPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 3, p e59373 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marcio Nucci Flavio Queiroz-Telles Tito Alvarado-Matute Iris Nora Tiraboschi Jorge Cortes Jeannete Zurita Manuel Guzman-Blanco Maria Elena Santolaya Luis Thompson Jose Sifuentes-Osornio Juan I Echevarria Arnaldo L Colombo Latin American Invasive Mycosis Network Epidemiology of candidemia in Latin America: a laboratory-based survey.
description	<h4>Background</h4>The epidemiology of candidemia varies depending on the geographic region. Little is known about the epidemiology of candidemia in Latin America.<h4>Methods</h4>We conducted a 24-month laboratory-based survey of candidemia in 20 centers of seven Latin American countries. Incidence rates were calculated and the epidemiology of candidemia was characterized.<h4>Results</h4>Among 672 episodes of candidemia, 297 (44.2%) occurred in children (23.7% younger than 1 year), 36.2% in adults between 19 and 60 years old and 19.6% in elderly patients. The overall incidence was 1.18 cases per 1,000 admissions, and varied across countries, with the highest incidence in Colombia and the lowest in Chile. Candida albicans (37.6%), C. parapsilosis (26.5%) and C. tropicalis (17.6%) were the leading agents, with great variability in species distribution in the different countries. Most isolates were highly susceptible to fluconazole, voriconazole, amphotericin B and anidulafungin. Fluconazole was the most frequent agent used as primary treatment (65.8%), and the overall 30-day survival was 59.3%.<h4>Conclusions</h4>This first large epidemiologic study of candidemia in Latin America showed a high incidence of candidemia, high percentage of children, typical species distribution, with C. albicans, C. parapsilosis and C. tropicalis accounting for the majority of episodes, and low resistance rates.
format	article
author	Marcio Nucci Flavio Queiroz-Telles Tito Alvarado-Matute Iris Nora Tiraboschi Jorge Cortes Jeannete Zurita Manuel Guzman-Blanco Maria Elena Santolaya Luis Thompson Jose Sifuentes-Osornio Juan I Echevarria Arnaldo L Colombo Latin American Invasive Mycosis Network
author_facet	Marcio Nucci Flavio Queiroz-Telles Tito Alvarado-Matute Iris Nora Tiraboschi Jorge Cortes Jeannete Zurita Manuel Guzman-Blanco Maria Elena Santolaya Luis Thompson Jose Sifuentes-Osornio Juan I Echevarria Arnaldo L Colombo Latin American Invasive Mycosis Network
author_sort	Marcio Nucci
title	Epidemiology of candidemia in Latin America: a laboratory-based survey.
title_short	Epidemiology of candidemia in Latin America: a laboratory-based survey.
title_full	Epidemiology of candidemia in Latin America: a laboratory-based survey.
title_fullStr	Epidemiology of candidemia in Latin America: a laboratory-based survey.
title_full_unstemmed	Epidemiology of candidemia in Latin America: a laboratory-based survey.
title_sort	epidemiology of candidemia in latin america: a laboratory-based survey.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/4ec7e0fc917b496183fa5a630f9deebd
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Epidemiology of candidemia in Latin America: a laboratory-based survey.

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