Inhibition of miR-96-5p in the mouse brain increases glutathione levels by altering NOVA1 expression

Chisato Kinoshita et al. use a microbubble and ultrasound delivery system to inhibit miR-96-5p in the mouse brain. They demonstrate that miR96-5p regulates glutathione levels through the NOVA1 RNA binding protein, suggesting that this microRNA could be a target for altering glutathione levels in neu...

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Autores principales:	Chisato Kinoshita, Kazue Kikuchi-Utsumi, Koji Aoyama, Ryo Suzuki, Yayoi Okamoto, Nobuko Matsumura, Daiki Omata, Kazuo Maruyama, Toshio Nakaki
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/4ec843332a5e4a27be302abc87f8c949
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spelling	oai:doaj.org-article:4ec843332a5e4a27be302abc87f8c9492021-12-02T14:11:03ZInhibition of miR-96-5p in the mouse brain increases glutathione levels by altering NOVA1 expression10.1038/s42003-021-01706-02399-3642https://doaj.org/article/4ec843332a5e4a27be302abc87f8c9492021-02-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01706-0https://doaj.org/toc/2399-3642Chisato Kinoshita et al. use a microbubble and ultrasound delivery system to inhibit miR-96-5p in the mouse brain. They demonstrate that miR96-5p regulates glutathione levels through the NOVA1 RNA binding protein, suggesting that this microRNA could be a target for altering glutathione levels in neurodegenerative disease.Chisato KinoshitaKazue Kikuchi-UtsumiKoji AoyamaRyo SuzukiYayoi OkamotoNobuko MatsumuraDaiki OmataKazuo MaruyamaToshio NakakiNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Chisato Kinoshita Kazue Kikuchi-Utsumi Koji Aoyama Ryo Suzuki Yayoi Okamoto Nobuko Matsumura Daiki Omata Kazuo Maruyama Toshio Nakaki Inhibition of miR-96-5p in the mouse brain increases glutathione levels by altering NOVA1 expression
description	Chisato Kinoshita et al. use a microbubble and ultrasound delivery system to inhibit miR-96-5p in the mouse brain. They demonstrate that miR96-5p regulates glutathione levels through the NOVA1 RNA binding protein, suggesting that this microRNA could be a target for altering glutathione levels in neurodegenerative disease.
format	article
author	Chisato Kinoshita Kazue Kikuchi-Utsumi Koji Aoyama Ryo Suzuki Yayoi Okamoto Nobuko Matsumura Daiki Omata Kazuo Maruyama Toshio Nakaki
author_facet	Chisato Kinoshita Kazue Kikuchi-Utsumi Koji Aoyama Ryo Suzuki Yayoi Okamoto Nobuko Matsumura Daiki Omata Kazuo Maruyama Toshio Nakaki
author_sort	Chisato Kinoshita
title	Inhibition of miR-96-5p in the mouse brain increases glutathione levels by altering NOVA1 expression
title_short	Inhibition of miR-96-5p in the mouse brain increases glutathione levels by altering NOVA1 expression
title_full	Inhibition of miR-96-5p in the mouse brain increases glutathione levels by altering NOVA1 expression
title_fullStr	Inhibition of miR-96-5p in the mouse brain increases glutathione levels by altering NOVA1 expression
title_full_unstemmed	Inhibition of miR-96-5p in the mouse brain increases glutathione levels by altering NOVA1 expression
title_sort	inhibition of mir-96-5p in the mouse brain increases glutathione levels by altering nova1 expression
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4ec843332a5e4a27be302abc87f8c949
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Inhibition of miR-96-5p in the mouse brain increases glutathione levels by altering NOVA1 expression

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