Influence of spatial structure on protein damage susceptibility: a bioinformatics approach

Abstract Aging research is a very popular field of research in which the deterioration or decline of various physiological features is studied. Here we consider the molecular level, which can also have effects on the macroscopic level. The proteinogenic amino acids differ in their susceptibilities t...

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Autores principales:	Maximilian Fichtner, Stefan Schuster, Heiko Stark
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4ec92a976d9c4b278197893a9252cfa2
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spelling	oai:doaj.org-article:4ec92a976d9c4b278197893a9252cfa22021-12-02T13:20:21ZInfluence of spatial structure on protein damage susceptibility: a bioinformatics approach10.1038/s41598-021-84061-82045-2322https://doaj.org/article/4ec92a976d9c4b278197893a9252cfa22021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84061-8https://doaj.org/toc/2045-2322Abstract Aging research is a very popular field of research in which the deterioration or decline of various physiological features is studied. Here we consider the molecular level, which can also have effects on the macroscopic level. The proteinogenic amino acids differ in their susceptibilities to non-enzymatic modification. Some of these modifications can lead to protein damage and thus can affect the form and function of proteins. For this, it is important to know the distribution of amino acids between the protein shell/surface and the core. This was investigated in this study for all known structures of peptides and proteins available in the PDB. As a result, it is shown that the shell contains less susceptible amino acids than the core with the exception of thermophilic organisms. Furthermore, proteins could be classified according to their susceptibility. This can then be used in applications such as phylogeny, aging research, molecular medicine, and synthetic biology.Maximilian FichtnerStefan SchusterHeiko StarkNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maximilian Fichtner Stefan Schuster Heiko Stark Influence of spatial structure on protein damage susceptibility: a bioinformatics approach
description	Abstract Aging research is a very popular field of research in which the deterioration or decline of various physiological features is studied. Here we consider the molecular level, which can also have effects on the macroscopic level. The proteinogenic amino acids differ in their susceptibilities to non-enzymatic modification. Some of these modifications can lead to protein damage and thus can affect the form and function of proteins. For this, it is important to know the distribution of amino acids between the protein shell/surface and the core. This was investigated in this study for all known structures of peptides and proteins available in the PDB. As a result, it is shown that the shell contains less susceptible amino acids than the core with the exception of thermophilic organisms. Furthermore, proteins could be classified according to their susceptibility. This can then be used in applications such as phylogeny, aging research, molecular medicine, and synthetic biology.
format	article
author	Maximilian Fichtner Stefan Schuster Heiko Stark
author_facet	Maximilian Fichtner Stefan Schuster Heiko Stark
author_sort	Maximilian Fichtner
title	Influence of spatial structure on protein damage susceptibility: a bioinformatics approach
title_short	Influence of spatial structure on protein damage susceptibility: a bioinformatics approach
title_full	Influence of spatial structure on protein damage susceptibility: a bioinformatics approach
title_fullStr	Influence of spatial structure on protein damage susceptibility: a bioinformatics approach
title_full_unstemmed	Influence of spatial structure on protein damage susceptibility: a bioinformatics approach
title_sort	influence of spatial structure on protein damage susceptibility: a bioinformatics approach
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4ec92a976d9c4b278197893a9252cfa2
work_keys_str_mv	AT maximilianfichtner influenceofspatialstructureonproteindamagesusceptibilityabioinformaticsapproach AT stefanschuster influenceofspatialstructureonproteindamagesusceptibilityabioinformaticsapproach AT heikostark influenceofspatialstructureonproteindamagesusceptibilityabioinformaticsapproach
_version_	1718393209221021696

Influence of spatial structure on protein damage susceptibility: a bioinformatics approach

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