Multiferroic coreshell magnetoelectric nanoparticles as NMR sensitive nanoprobes for cancer cell detection

Abstract Magnetoelectric (ME) nanoparticles (MENs) intrinsically couple magnetic and electric fields. Using them as nuclear magnetic resonance (NMR) sensitive nanoprobes adds another dimension for NMR detection of biological cells based on the cell type and corresponding particle association with th...

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Autores principales:	Abhignyan Nagesetti, Alexandra Rodzinski, Emmanuel Stimphil, Tiffanie Stewart, Chooda Khanal, Ping Wang, Rakesh Guduru, Ping Liang, Irina Agoulnik, Jeffrey Horstmyer, Sakhrat Khizroev
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4ec9e682341a4dd2af0a9ede6d252f22
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spelling	oai:doaj.org-article:4ec9e682341a4dd2af0a9ede6d252f222021-12-02T11:52:19ZMultiferroic coreshell magnetoelectric nanoparticles as NMR sensitive nanoprobes for cancer cell detection10.1038/s41598-017-01647-x2045-2322https://doaj.org/article/4ec9e682341a4dd2af0a9ede6d252f222017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01647-xhttps://doaj.org/toc/2045-2322Abstract Magnetoelectric (ME) nanoparticles (MENs) intrinsically couple magnetic and electric fields. Using them as nuclear magnetic resonance (NMR) sensitive nanoprobes adds another dimension for NMR detection of biological cells based on the cell type and corresponding particle association with the cell. Based on ME property, for the first time we show that MENs can distinguish different cancer cells among themselves as well as from their normal counterparts. The core-shell nanoparticles are 30 nm in size and were not superparamagnetic. Due to presence of the ME effect, these nanoparticles can significantly enhance the electric field configuration on the cell membrane which serves as a signature characteristic depending on the cancer cell type and progression stage. This was clearly observed by a significant change in the NMR absorption spectra of cells incubated with MENs. In contrast, conventional cobalt ferrite magnetic nanoparticles (MNPs) did not show any change in the NMR absorption spectra. We conclude that different membrane properties of cells which result in distinct MEN organization and the minimization of electrical energy due to particle binding to the cells contribute to the NMR signal. The nanoprobe based NMR spectroscopy has the potential to enable rapid screening of cancers and impact next-generation cancer diagnostic exams.Abhignyan NagesettiAlexandra RodzinskiEmmanuel StimphilTiffanie StewartChooda KhanalPing WangRakesh GuduruPing LiangIrina AgoulnikJeffrey HorstmyerSakhrat KhizroevNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Abhignyan Nagesetti Alexandra Rodzinski Emmanuel Stimphil Tiffanie Stewart Chooda Khanal Ping Wang Rakesh Guduru Ping Liang Irina Agoulnik Jeffrey Horstmyer Sakhrat Khizroev Multiferroic coreshell magnetoelectric nanoparticles as NMR sensitive nanoprobes for cancer cell detection
description	Abstract Magnetoelectric (ME) nanoparticles (MENs) intrinsically couple magnetic and electric fields. Using them as nuclear magnetic resonance (NMR) sensitive nanoprobes adds another dimension for NMR detection of biological cells based on the cell type and corresponding particle association with the cell. Based on ME property, for the first time we show that MENs can distinguish different cancer cells among themselves as well as from their normal counterparts. The core-shell nanoparticles are 30 nm in size and were not superparamagnetic. Due to presence of the ME effect, these nanoparticles can significantly enhance the electric field configuration on the cell membrane which serves as a signature characteristic depending on the cancer cell type and progression stage. This was clearly observed by a significant change in the NMR absorption spectra of cells incubated with MENs. In contrast, conventional cobalt ferrite magnetic nanoparticles (MNPs) did not show any change in the NMR absorption spectra. We conclude that different membrane properties of cells which result in distinct MEN organization and the minimization of electrical energy due to particle binding to the cells contribute to the NMR signal. The nanoprobe based NMR spectroscopy has the potential to enable rapid screening of cancers and impact next-generation cancer diagnostic exams.
format	article
author	Abhignyan Nagesetti Alexandra Rodzinski Emmanuel Stimphil Tiffanie Stewart Chooda Khanal Ping Wang Rakesh Guduru Ping Liang Irina Agoulnik Jeffrey Horstmyer Sakhrat Khizroev
author_facet	Abhignyan Nagesetti Alexandra Rodzinski Emmanuel Stimphil Tiffanie Stewart Chooda Khanal Ping Wang Rakesh Guduru Ping Liang Irina Agoulnik Jeffrey Horstmyer Sakhrat Khizroev
author_sort	Abhignyan Nagesetti
title	Multiferroic coreshell magnetoelectric nanoparticles as NMR sensitive nanoprobes for cancer cell detection
title_short	Multiferroic coreshell magnetoelectric nanoparticles as NMR sensitive nanoprobes for cancer cell detection
title_full	Multiferroic coreshell magnetoelectric nanoparticles as NMR sensitive nanoprobes for cancer cell detection
title_fullStr	Multiferroic coreshell magnetoelectric nanoparticles as NMR sensitive nanoprobes for cancer cell detection
title_full_unstemmed	Multiferroic coreshell magnetoelectric nanoparticles as NMR sensitive nanoprobes for cancer cell detection
title_sort	multiferroic coreshell magnetoelectric nanoparticles as nmr sensitive nanoprobes for cancer cell detection
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/4ec9e682341a4dd2af0a9ede6d252f22
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Multiferroic coreshell magnetoelectric nanoparticles as NMR sensitive nanoprobes for cancer cell detection

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