A novel temperature-responsive micelle for enhancing combination therapy

Cheng-Liang Peng,1,* Yuan-I Chen,2,3,* Hung-Jen Liu,2 Pei-Chi Lee,2 Tsai-Yueh Luo,1 Ming-Jium Shieh2,3 1Isotope Application Division, Institute of Nuclear Energy Research, Taoyuan, 2Institute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taip...

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Autores principales:	Peng CL, Chen YI, Liu HJ, Lee PC, Luo TY, Shieh MJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	thermosensitive photothermal therapy chemotherapy nano-carrier control release synergistic effect Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/4eca743a1d94455a84761233f26185ef
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spelling	oai:doaj.org-article:4eca743a1d94455a84761233f26185ef2021-12-02T03:54:13ZA novel temperature-responsive micelle for enhancing combination therapy1178-2013https://doaj.org/article/4eca743a1d94455a84761233f26185ef2016-07-01T00:00:00Zhttps://www.dovepress.com/a-novel-temperature-responsive-micelle-for-enhancing-combination-thera-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Cheng-Liang Peng,1,* Yuan-I Chen,2,3,* Hung-Jen Liu,2 Pei-Chi Lee,2 Tsai-Yueh Luo,1 Ming-Jium Shieh2,3 1Isotope Application Division, Institute of Nuclear Energy Research, Taoyuan, 2Institute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei, 3Department of Oncology, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan *These authors contributed equally to this work Abstract: A novel thermosensitive polymer p(N-isopropylacrylamide-co-poly[ethylene glycol] methyl ether acrylate)-block-poly(epsilon-caprolactone), p(NIPAAM-co-PEGMEA)-b-PCL, was synthesized and developed as nanomicelles. The hydrophobic heat shock protein 90 inhibitor 17-allylamino-17-demethoxygeldanamycin and the photosensitizer cyanine dye infrared-780 were loaded into the core of the micelles to achieve both chemotherapy and photothermal therapy simultaneously at the tumor site. The release of the drug could be controlled by varying the temperature due to the thermosensitive nature of the micelles. The micelles were less than 200 nm in size, and the drug encapsulation efficiency was >50%. The critical micelle concentrations were small enough to allow micelle stability upon dilution. Data from cell viability and animal experiments indicate that this combination treatment using photothermal therapy with chemotherapy had synergistic effects while decreasing side effects. Keywords: thermosensitive, photothermal therapy, chemotherapy, nanocarrier, control release, synergistic effectPeng CLChen YILiu HJLee PCLuo TYShieh MJDove Medical Pressarticlethermosensitivephotothermal therapychemotherapynano-carriercontrol releasesynergistic effectMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2016, Iss default, Pp 3357-3369 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	thermosensitive photothermal therapy chemotherapy nano-carrier control release synergistic effect Medicine (General) R5-920
spellingShingle	thermosensitive photothermal therapy chemotherapy nano-carrier control release synergistic effect Medicine (General) R5-920 Peng CL Chen YI Liu HJ Lee PC Luo TY Shieh MJ A novel temperature-responsive micelle for enhancing combination therapy
description	Cheng-Liang Peng,1,* Yuan-I Chen,2,3,* Hung-Jen Liu,2 Pei-Chi Lee,2 Tsai-Yueh Luo,1 Ming-Jium Shieh2,3 1Isotope Application Division, Institute of Nuclear Energy Research, Taoyuan, 2Institute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei, 3Department of Oncology, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan *These authors contributed equally to this work Abstract: A novel thermosensitive polymer p(N-isopropylacrylamide-co-poly[ethylene glycol] methyl ether acrylate)-block-poly(epsilon-caprolactone), p(NIPAAM-co-PEGMEA)-b-PCL, was synthesized and developed as nanomicelles. The hydrophobic heat shock protein 90 inhibitor 17-allylamino-17-demethoxygeldanamycin and the photosensitizer cyanine dye infrared-780 were loaded into the core of the micelles to achieve both chemotherapy and photothermal therapy simultaneously at the tumor site. The release of the drug could be controlled by varying the temperature due to the thermosensitive nature of the micelles. The micelles were less than 200 nm in size, and the drug encapsulation efficiency was >50%. The critical micelle concentrations were small enough to allow micelle stability upon dilution. Data from cell viability and animal experiments indicate that this combination treatment using photothermal therapy with chemotherapy had synergistic effects while decreasing side effects. Keywords: thermosensitive, photothermal therapy, chemotherapy, nanocarrier, control release, synergistic effect
format	article
author	Peng CL Chen YI Liu HJ Lee PC Luo TY Shieh MJ
author_facet	Peng CL Chen YI Liu HJ Lee PC Luo TY Shieh MJ
author_sort	Peng CL
title	A novel temperature-responsive micelle for enhancing combination therapy
title_short	A novel temperature-responsive micelle for enhancing combination therapy
title_full	A novel temperature-responsive micelle for enhancing combination therapy
title_fullStr	A novel temperature-responsive micelle for enhancing combination therapy
title_full_unstemmed	A novel temperature-responsive micelle for enhancing combination therapy
title_sort	novel temperature-responsive micelle for enhancing combination therapy
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/4eca743a1d94455a84761233f26185ef
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_version_	1718401546912268288

A novel temperature-responsive micelle for enhancing combination therapy

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