Transcriptomic landscape of the blastema niche in regenerating adult axolotl limbs at single-cell resolution

Limb regeneration requires a blastema with progenitor cells, immune cells, and an overlying wound epidermis, but molecular identities of these populations are unclear. Here, the authors use single-cell RNA-sequencing to identify transcriptionally distinct cell populations in adult axolotl limb blast...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Nicholas D. Leigh, Garrett S. Dunlap, Kimberly Johnson, Rachelle Mariano, Rachel Oshiro, Alan Y. Wong, Donald M. Bryant, Bess M. Miller, Alex Ratner, Andy Chen, William W. Ye, Brian J. Haas, Jessica L. Whited
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4ed4afd9e0f24ba282c5975966235607
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4ed4afd9e0f24ba282c5975966235607
record_format	dspace
spelling	oai:doaj.org-article:4ed4afd9e0f24ba282c59759662356072021-12-02T13:27:23ZTranscriptomic landscape of the blastema niche in regenerating adult axolotl limbs at single-cell resolution10.1038/s41467-018-07604-02041-1723https://doaj.org/article/4ed4afd9e0f24ba282c59759662356072018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07604-0https://doaj.org/toc/2041-1723Limb regeneration requires a blastema with progenitor cells, immune cells, and an overlying wound epidermis, but molecular identities of these populations are unclear. Here, the authors use single-cell RNA-sequencing to identify transcriptionally distinct cell populations in adult axolotl limb blastemas.Nicholas D. LeighGarrett S. DunlapKimberly JohnsonRachelle MarianoRachel OshiroAlan Y. WongDonald M. BryantBess M. MillerAlex RatnerAndy ChenWilliam W. YeBrian J. HaasJessica L. WhitedNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nicholas D. Leigh Garrett S. Dunlap Kimberly Johnson Rachelle Mariano Rachel Oshiro Alan Y. Wong Donald M. Bryant Bess M. Miller Alex Ratner Andy Chen William W. Ye Brian J. Haas Jessica L. Whited Transcriptomic landscape of the blastema niche in regenerating adult axolotl limbs at single-cell resolution
description	Limb regeneration requires a blastema with progenitor cells, immune cells, and an overlying wound epidermis, but molecular identities of these populations are unclear. Here, the authors use single-cell RNA-sequencing to identify transcriptionally distinct cell populations in adult axolotl limb blastemas.
format	article
author	Nicholas D. Leigh Garrett S. Dunlap Kimberly Johnson Rachelle Mariano Rachel Oshiro Alan Y. Wong Donald M. Bryant Bess M. Miller Alex Ratner Andy Chen William W. Ye Brian J. Haas Jessica L. Whited
author_facet	Nicholas D. Leigh Garrett S. Dunlap Kimberly Johnson Rachelle Mariano Rachel Oshiro Alan Y. Wong Donald M. Bryant Bess M. Miller Alex Ratner Andy Chen William W. Ye Brian J. Haas Jessica L. Whited
author_sort	Nicholas D. Leigh
title	Transcriptomic landscape of the blastema niche in regenerating adult axolotl limbs at single-cell resolution
title_short	Transcriptomic landscape of the blastema niche in regenerating adult axolotl limbs at single-cell resolution
title_full	Transcriptomic landscape of the blastema niche in regenerating adult axolotl limbs at single-cell resolution
title_fullStr	Transcriptomic landscape of the blastema niche in regenerating adult axolotl limbs at single-cell resolution
title_full_unstemmed	Transcriptomic landscape of the blastema niche in regenerating adult axolotl limbs at single-cell resolution
title_sort	transcriptomic landscape of the blastema niche in regenerating adult axolotl limbs at single-cell resolution
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/4ed4afd9e0f24ba282c5975966235607
work_keys_str_mv	AT nicholasdleigh transcriptomiclandscapeoftheblastemanicheinregeneratingadultaxolotllimbsatsinglecellresolution AT garrettsdunlap transcriptomiclandscapeoftheblastemanicheinregeneratingadultaxolotllimbsatsinglecellresolution AT kimberlyjohnson transcriptomiclandscapeoftheblastemanicheinregeneratingadultaxolotllimbsatsinglecellresolution AT rachellemariano transcriptomiclandscapeoftheblastemanicheinregeneratingadultaxolotllimbsatsinglecellresolution AT racheloshiro transcriptomiclandscapeoftheblastemanicheinregeneratingadultaxolotllimbsatsinglecellresolution AT alanywong transcriptomiclandscapeoftheblastemanicheinregeneratingadultaxolotllimbsatsinglecellresolution AT donaldmbryant transcriptomiclandscapeoftheblastemanicheinregeneratingadultaxolotllimbsatsinglecellresolution AT bessmmiller transcriptomiclandscapeoftheblastemanicheinregeneratingadultaxolotllimbsatsinglecellresolution AT alexratner transcriptomiclandscapeoftheblastemanicheinregeneratingadultaxolotllimbsatsinglecellresolution AT andychen transcriptomiclandscapeoftheblastemanicheinregeneratingadultaxolotllimbsatsinglecellresolution AT williamwye transcriptomiclandscapeoftheblastemanicheinregeneratingadultaxolotllimbsatsinglecellresolution AT brianjhaas transcriptomiclandscapeoftheblastemanicheinregeneratingadultaxolotllimbsatsinglecellresolution AT jessicalwhited transcriptomiclandscapeoftheblastemanicheinregeneratingadultaxolotllimbsatsinglecellresolution
_version_	1718392973451853824

Transcriptomic landscape of the blastema niche in regenerating adult axolotl limbs at single-cell resolution

Ejemplares similares