MDA5 disease variant M854K prevents ATP-dependent structural discrimination of viral and cellular RNA

MDA5 is the primary immune sensor for SARS-CoV-2 and many other viruses. Mutations in MDA5 can cause disease. Here the authors employ CryoEM and biochemical methods to show how steric constraints cause MDA5 to misrecognize endogenous RNA as viral RNA.

Guardado en:

Detalles Bibliográficos
Autores principales:	Qin Yu, Alba Herrero del Valle, Rahul Singh, Yorgo Modis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4ed51115fdf7407f8d5ba6033a51c511
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4ed51115fdf7407f8d5ba6033a51c511
record_format	dspace
spelling	oai:doaj.org-article:4ed51115fdf7407f8d5ba6033a51c5112021-11-21T12:34:35ZMDA5 disease variant M854K prevents ATP-dependent structural discrimination of viral and cellular RNA10.1038/s41467-021-27062-52041-1723https://doaj.org/article/4ed51115fdf7407f8d5ba6033a51c5112021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27062-5https://doaj.org/toc/2041-1723MDA5 is the primary immune sensor for SARS-CoV-2 and many other viruses. Mutations in MDA5 can cause disease. Here the authors employ CryoEM and biochemical methods to show how steric constraints cause MDA5 to misrecognize endogenous RNA as viral RNA.Qin YuAlba Herrero del ValleRahul SinghYorgo ModisNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qin Yu Alba Herrero del Valle Rahul Singh Yorgo Modis MDA5 disease variant M854K prevents ATP-dependent structural discrimination of viral and cellular RNA
description	MDA5 is the primary immune sensor for SARS-CoV-2 and many other viruses. Mutations in MDA5 can cause disease. Here the authors employ CryoEM and biochemical methods to show how steric constraints cause MDA5 to misrecognize endogenous RNA as viral RNA.
format	article
author	Qin Yu Alba Herrero del Valle Rahul Singh Yorgo Modis
author_facet	Qin Yu Alba Herrero del Valle Rahul Singh Yorgo Modis
author_sort	Qin Yu
title	MDA5 disease variant M854K prevents ATP-dependent structural discrimination of viral and cellular RNA
title_short	MDA5 disease variant M854K prevents ATP-dependent structural discrimination of viral and cellular RNA
title_full	MDA5 disease variant M854K prevents ATP-dependent structural discrimination of viral and cellular RNA
title_fullStr	MDA5 disease variant M854K prevents ATP-dependent structural discrimination of viral and cellular RNA
title_full_unstemmed	MDA5 disease variant M854K prevents ATP-dependent structural discrimination of viral and cellular RNA
title_sort	mda5 disease variant m854k prevents atp-dependent structural discrimination of viral and cellular rna
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4ed51115fdf7407f8d5ba6033a51c511
work_keys_str_mv	AT qinyu mda5diseasevariantm854kpreventsatpdependentstructuraldiscriminationofviralandcellularrna AT albaherrerodelvalle mda5diseasevariantm854kpreventsatpdependentstructuraldiscriminationofviralandcellularrna AT rahulsingh mda5diseasevariantm854kpreventsatpdependentstructuraldiscriminationofviralandcellularrna AT yorgomodis mda5diseasevariantm854kpreventsatpdependentstructuraldiscriminationofviralandcellularrna
_version_	1718418881383497728

MDA5 disease variant M854K prevents ATP-dependent structural discrimination of viral and cellular RNA

Ejemplares similares