Participation of NO in the vasodilatory action of isoespintanol
Background: accumulating evidence suggests that natural compounds and specifically monoterpenes exert a vasodilator action. Objetive: to investigate the vascular effects of isoespintanol (2-isopropil-3,6- dimetoxi-5-metilfenol, ISO) monoterpene isolated from the leaves of Oxandra cf xylopioides. Me...
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Universidad de Antioquia
2019
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oai:doaj.org-article:4ed51b4f6f104edcbff4e9c3d0c55a032021-12-02T19:42:45ZParticipation of NO in the vasodilatory action of isoespintanol10.17533/udea.vitae.v26n2a030121-40042145-2660https://doaj.org/article/4ed51b4f6f104edcbff4e9c3d0c55a032019-11-01T00:00:00Zhttps://revistas.udea.edu.co/index.php/vitae/article/view/336274https://doaj.org/toc/0121-4004https://doaj.org/toc/2145-2660 Background: accumulating evidence suggests that natural compounds and specifically monoterpenes exert a vasodilator action. Objetive: to investigate the vascular effects of isoespintanol (2-isopropil-3,6- dimetoxi-5-metilfenol, ISO) monoterpene isolated from the leaves of Oxandra cf xylopioides. Methods: thoracic aortic rings isolated from Wistar rats were contracted with KCl 80 mM and then relaxed by exposure to Ca2+-free solution in absence and in presence of ISO 0.6 mg/mL. The force/tissue ratio (F/W) and the time to obtain 50% of relaxation (T-50) were used to assess the maximal contractile response and the relaxation, respectively. To examine the participation of NO additional experiments were performed under inhibition of nitric oxide synthase with L-NAME (L-NG-Nitroarginine methyl ester). Results: ISO significantly decreased the F/W ratio (257 ± 19 vs. 360 ± 18) and did not change T-50. In presence of L-NAME the effects of ISO on contractile response was abolished. Conclusions: these results demonstrate that ISO exerts a vasodilator effect through NO- dependent pathways and suggest that an inhibition of calcium influx could be the involved mechanism. Gustavo J. RINALDIBenjamín ROJANOGuillermo SCHINELLASusana M. MOSCAUniversidad de AntioquiaarticleIsoespintanolthoracic aortanitric oxide (NO).Food processing and manufactureTP368-456Pharmaceutical industryHD9665-9675ENVitae, Vol 26, Iss 2 (2019) |
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Isoespintanol thoracic aorta nitric oxide (NO). Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675 |
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Isoespintanol thoracic aorta nitric oxide (NO). Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675 Gustavo J. RINALDI Benjamín ROJANO Guillermo SCHINELLA Susana M. MOSCA Participation of NO in the vasodilatory action of isoespintanol |
description |
Background: accumulating evidence suggests that natural compounds and specifically monoterpenes exert a vasodilator action. Objetive: to investigate the vascular effects of isoespintanol (2-isopropil-3,6- dimetoxi-5-metilfenol, ISO) monoterpene isolated from the leaves of Oxandra cf xylopioides. Methods: thoracic aortic rings isolated from Wistar rats were contracted with KCl 80 mM and then relaxed by exposure to Ca2+-free solution in absence and in presence of ISO 0.6 mg/mL. The force/tissue ratio (F/W) and the time to obtain 50% of relaxation (T-50) were used to assess the maximal contractile response and the relaxation, respectively. To examine the participation of NO additional experiments were performed under inhibition of nitric oxide synthase with L-NAME (L-NG-Nitroarginine methyl ester). Results: ISO significantly decreased the F/W ratio (257 ± 19 vs. 360 ± 18) and did not change T-50. In presence of L-NAME the effects of ISO on contractile response was abolished. Conclusions: these results demonstrate that ISO exerts a vasodilator effect through NO- dependent pathways and suggest that an inhibition of calcium influx could be the involved mechanism.
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format |
article |
author |
Gustavo J. RINALDI Benjamín ROJANO Guillermo SCHINELLA Susana M. MOSCA |
author_facet |
Gustavo J. RINALDI Benjamín ROJANO Guillermo SCHINELLA Susana M. MOSCA |
author_sort |
Gustavo J. RINALDI |
title |
Participation of NO in the vasodilatory action of isoespintanol |
title_short |
Participation of NO in the vasodilatory action of isoespintanol |
title_full |
Participation of NO in the vasodilatory action of isoespintanol |
title_fullStr |
Participation of NO in the vasodilatory action of isoespintanol |
title_full_unstemmed |
Participation of NO in the vasodilatory action of isoespintanol |
title_sort |
participation of no in the vasodilatory action of isoespintanol |
publisher |
Universidad de Antioquia |
publishDate |
2019 |
url |
https://doaj.org/article/4ed51b4f6f104edcbff4e9c3d0c55a03 |
work_keys_str_mv |
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