Participation of NO in the vasodilatory action of isoespintanol

Background: accumulating evidence suggests that natural compounds and specifically monoterpenes exert a vasodilator action. Objetive: to investigate the vascular effects of isoespintanol (2-isopropil-3,6- dimetoxi-5-metilfenol, ISO) monoterpene isolated from the leaves of Oxandra cf xylopioides. Me...

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Autores principales: Gustavo J. RINALDI, Benjamín ROJANO, Guillermo SCHINELLA, Susana M. MOSCA
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Lenguaje:EN
Publicado: Universidad de Antioquia 2019
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spelling oai:doaj.org-article:4ed51b4f6f104edcbff4e9c3d0c55a032021-12-02T19:42:45ZParticipation of NO in the vasodilatory action of isoespintanol10.17533/udea.vitae.v26n2a030121-40042145-2660https://doaj.org/article/4ed51b4f6f104edcbff4e9c3d0c55a032019-11-01T00:00:00Zhttps://revistas.udea.edu.co/index.php/vitae/article/view/336274https://doaj.org/toc/0121-4004https://doaj.org/toc/2145-2660 Background: accumulating evidence suggests that natural compounds and specifically monoterpenes exert a vasodilator action. Objetive: to investigate the vascular effects of isoespintanol (2-isopropil-3,6- dimetoxi-5-metilfenol, ISO) monoterpene isolated from the leaves of Oxandra cf xylopioides. Methods: thoracic aortic rings isolated from Wistar rats were contracted with KCl 80 mM and then relaxed by exposure to Ca2+-free solution in absence and in presence of ISO 0.6 mg/mL. The force/tissue ratio (F/W) and the time to obtain 50% of relaxation (T-50) were used to assess the maximal contractile response and the relaxation, respectively. To examine the participation of NO additional experiments were performed under inhibition of nitric oxide synthase with L-NAME (L-NG-Nitroarginine methyl ester). Results: ISO significantly decreased the F/W ratio (257 ± 19 vs. 360 ± 18) and did not change T-50. In presence of L-NAME the effects of ISO on contractile response was abolished. Conclusions: these results demonstrate that ISO exerts a vasodilator effect through NO- dependent pathways and suggest that an inhibition of calcium influx could be the involved mechanism. Gustavo J. RINALDIBenjamín ROJANOGuillermo SCHINELLASusana M. MOSCAUniversidad de AntioquiaarticleIsoespintanolthoracic aortanitric oxide (NO).Food processing and manufactureTP368-456Pharmaceutical industryHD9665-9675ENVitae, Vol 26, Iss 2 (2019)
institution DOAJ
collection DOAJ
language EN
topic Isoespintanol
thoracic aorta
nitric oxide (NO).
Food processing and manufacture
TP368-456
Pharmaceutical industry
HD9665-9675
spellingShingle Isoespintanol
thoracic aorta
nitric oxide (NO).
Food processing and manufacture
TP368-456
Pharmaceutical industry
HD9665-9675
Gustavo J. RINALDI
Benjamín ROJANO
Guillermo SCHINELLA
Susana M. MOSCA
Participation of NO in the vasodilatory action of isoespintanol
description Background: accumulating evidence suggests that natural compounds and specifically monoterpenes exert a vasodilator action. Objetive: to investigate the vascular effects of isoespintanol (2-isopropil-3,6- dimetoxi-5-metilfenol, ISO) monoterpene isolated from the leaves of Oxandra cf xylopioides. Methods: thoracic aortic rings isolated from Wistar rats were contracted with KCl 80 mM and then relaxed by exposure to Ca2+-free solution in absence and in presence of ISO 0.6 mg/mL. The force/tissue ratio (F/W) and the time to obtain 50% of relaxation (T-50) were used to assess the maximal contractile response and the relaxation, respectively. To examine the participation of NO additional experiments were performed under inhibition of nitric oxide synthase with L-NAME (L-NG-Nitroarginine methyl ester). Results: ISO significantly decreased the F/W ratio (257 ± 19 vs. 360 ± 18) and did not change T-50. In presence of L-NAME the effects of ISO on contractile response was abolished. Conclusions: these results demonstrate that ISO exerts a vasodilator effect through NO- dependent pathways and suggest that an inhibition of calcium influx could be the involved mechanism.
format article
author Gustavo J. RINALDI
Benjamín ROJANO
Guillermo SCHINELLA
Susana M. MOSCA
author_facet Gustavo J. RINALDI
Benjamín ROJANO
Guillermo SCHINELLA
Susana M. MOSCA
author_sort Gustavo J. RINALDI
title Participation of NO in the vasodilatory action of isoespintanol
title_short Participation of NO in the vasodilatory action of isoespintanol
title_full Participation of NO in the vasodilatory action of isoespintanol
title_fullStr Participation of NO in the vasodilatory action of isoespintanol
title_full_unstemmed Participation of NO in the vasodilatory action of isoespintanol
title_sort participation of no in the vasodilatory action of isoespintanol
publisher Universidad de Antioquia
publishDate 2019
url https://doaj.org/article/4ed51b4f6f104edcbff4e9c3d0c55a03
work_keys_str_mv AT gustavojrinaldi participationofnointhevasodilatoryactionofisoespintanol
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AT guillermoschinella participationofnointhevasodilatoryactionofisoespintanol
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