Cellular proteostasis decline in human senescence

A huge amount of intrigue surrounds the aging process. Senescence—the decreased likelihood of reproduction and the increased chance of mortality—is a hallmark of aging. The reduced ability of senescent cells to maintain protein homeostasis (proteostasis) has been well-established in nematodes but th...

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Autor principal:	Karli Montague-Cardoso
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/4ed7778eb2394cd581761c3fe019dc2a
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spelling	oai:doaj.org-article:4ed7778eb2394cd581761c3fe019dc2a2021-12-02T15:13:06ZCellular proteostasis decline in human senescence10.1038/s42003-020-01578-w2399-3642https://doaj.org/article/4ed7778eb2394cd581761c3fe019dc2a2021-01-01T00:00:00Zhttps://doi.org/10.1038/s42003-020-01578-whttps://doaj.org/toc/2399-3642A huge amount of intrigue surrounds the aging process. Senescence—the decreased likelihood of reproduction and the increased chance of mortality—is a hallmark of aging. The reduced ability of senescent cells to maintain protein homeostasis (proteostasis) has been well-established in nematodes but this phenomenon had yet to be directly demonstrated in human cells. Sabath et al. recently provided compelling evidence that proteostasis collapse is indeed intrinsic to human cell senescence, which may have broad implications in the underlying processes of human aging.Karli Montague-CardosoNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-2 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Karli Montague-Cardoso Cellular proteostasis decline in human senescence
description	A huge amount of intrigue surrounds the aging process. Senescence—the decreased likelihood of reproduction and the increased chance of mortality—is a hallmark of aging. The reduced ability of senescent cells to maintain protein homeostasis (proteostasis) has been well-established in nematodes but this phenomenon had yet to be directly demonstrated in human cells. Sabath et al. recently provided compelling evidence that proteostasis collapse is indeed intrinsic to human cell senescence, which may have broad implications in the underlying processes of human aging.
format	article
author	Karli Montague-Cardoso
author_facet	Karli Montague-Cardoso
author_sort	Karli Montague-Cardoso
title	Cellular proteostasis decline in human senescence
title_short	Cellular proteostasis decline in human senescence
title_full	Cellular proteostasis decline in human senescence
title_fullStr	Cellular proteostasis decline in human senescence
title_full_unstemmed	Cellular proteostasis decline in human senescence
title_sort	cellular proteostasis decline in human senescence
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4ed7778eb2394cd581761c3fe019dc2a
work_keys_str_mv	AT karlimontaguecardoso cellularproteostasisdeclineinhumansenescence
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Cellular proteostasis decline in human senescence

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