Hyaluronic acid-functionalized single-walled carbon nanotubes as tumor-targeting MRI contrast agent

Lin Hou,* Huijuan Zhang,* Yating Wang, Lili Wang, Xiaomin Yang, Zhenzhong ZhangSchool of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, People’s Republic of China*These authors contributed equally to this workAbstract: A tumor-targeting carrier, hyaluronic acid (HA)-fun...

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Autores principales:	Hou L, Zhang H, Wang Y, Wang L, Yang X, Zhang Z
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/4edddd8464ca48acbe312f16f6cf6346
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spelling	oai:doaj.org-article:4edddd8464ca48acbe312f16f6cf63462021-12-02T02:13:09ZHyaluronic acid-functionalized single-walled carbon nanotubes as tumor-targeting MRI contrast agent1178-2013https://doaj.org/article/4edddd8464ca48acbe312f16f6cf63462015-07-01T00:00:00Zhttp://www.dovepress.com/hyaluronic-acid-functionalized-single-walled-carbon-nanotubes-as-tumor-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Lin Hou,* Huijuan Zhang,* Yating Wang, Lili Wang, Xiaomin Yang, Zhenzhong ZhangSchool of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, People’s Republic of China*These authors contributed equally to this workAbstract: A tumor-targeting carrier, hyaluronic acid (HA)-functionalized single-walled carbon nanotubes (SWCNTs), was explored to deliver magnetic resonance imaging (MRI) contrast agents (CAs) targeting to the tumor cells specifically. In this system, HA surface modification for SWCNTs was simply accomplished by amidation process and could make this nanomaterial highly hydrophilic. Cellular uptake was performed to evaluate the intracellular transport capabilities of HA-SWCNTs for tumor cells and the uptake rank was HA-SWCNTs> SWCNTs owing to the presence of HA, which was also evidenced by flow cytometry. The safety evaluation of this MRI CAs was investigated in vitro and in vivo. It revealed that HA-SWCNTs could stand as a biocompatible nanocarrier and gadolinium (Gd)/HA-SWCNTs demonstrated almost no toxicity compared with free GdCl3. Moreover, GdCl3 bearing HA-SWCNTs could significantly increase the circulation time for MRI. Finally, to investigate the MRI contrast enhancing capabilities of Gd/HA-SWCNTs, T1-weighted MR images of tumor-bearing mice were acquired. The results suggested Gd/HA-SWCNTs had the highest tumor-targeting efficiency and T1-relaxivity enhancement, indicating HA-SWCNTs could be developed as a tumor-targeting carrier to deliver the CAs, GdCl3, for the identifiable diagnosis of tumor.Keywords: gadolinium, magnetic resonance, SWCNTs, hyaluronic acid, contrast agentHou LZhang HWang YWang LYang XZhang ZDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss default, Pp 4507-4520 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Hou L Zhang H Wang Y Wang L Yang X Zhang Z Hyaluronic acid-functionalized single-walled carbon nanotubes as tumor-targeting MRI contrast agent
description	Lin Hou,* Huijuan Zhang,* Yating Wang, Lili Wang, Xiaomin Yang, Zhenzhong ZhangSchool of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, People’s Republic of China*These authors contributed equally to this workAbstract: A tumor-targeting carrier, hyaluronic acid (HA)-functionalized single-walled carbon nanotubes (SWCNTs), was explored to deliver magnetic resonance imaging (MRI) contrast agents (CAs) targeting to the tumor cells specifically. In this system, HA surface modification for SWCNTs was simply accomplished by amidation process and could make this nanomaterial highly hydrophilic. Cellular uptake was performed to evaluate the intracellular transport capabilities of HA-SWCNTs for tumor cells and the uptake rank was HA-SWCNTs> SWCNTs owing to the presence of HA, which was also evidenced by flow cytometry. The safety evaluation of this MRI CAs was investigated in vitro and in vivo. It revealed that HA-SWCNTs could stand as a biocompatible nanocarrier and gadolinium (Gd)/HA-SWCNTs demonstrated almost no toxicity compared with free GdCl3. Moreover, GdCl3 bearing HA-SWCNTs could significantly increase the circulation time for MRI. Finally, to investigate the MRI contrast enhancing capabilities of Gd/HA-SWCNTs, T1-weighted MR images of tumor-bearing mice were acquired. The results suggested Gd/HA-SWCNTs had the highest tumor-targeting efficiency and T1-relaxivity enhancement, indicating HA-SWCNTs could be developed as a tumor-targeting carrier to deliver the CAs, GdCl3, for the identifiable diagnosis of tumor.Keywords: gadolinium, magnetic resonance, SWCNTs, hyaluronic acid, contrast agent
format	article
author	Hou L Zhang H Wang Y Wang L Yang X Zhang Z
author_facet	Hou L Zhang H Wang Y Wang L Yang X Zhang Z
author_sort	Hou L
title	Hyaluronic acid-functionalized single-walled carbon nanotubes as tumor-targeting MRI contrast agent
title_short	Hyaluronic acid-functionalized single-walled carbon nanotubes as tumor-targeting MRI contrast agent
title_full	Hyaluronic acid-functionalized single-walled carbon nanotubes as tumor-targeting MRI contrast agent
title_fullStr	Hyaluronic acid-functionalized single-walled carbon nanotubes as tumor-targeting MRI contrast agent
title_full_unstemmed	Hyaluronic acid-functionalized single-walled carbon nanotubes as tumor-targeting MRI contrast agent
title_sort	hyaluronic acid-functionalized single-walled carbon nanotubes as tumor-targeting mri contrast agent
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/4edddd8464ca48acbe312f16f6cf6346
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Hyaluronic acid-functionalized single-walled carbon nanotubes as tumor-targeting MRI contrast agent

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