Biodegradable Amphoteric Surfactants in Titration-Ultrasound Formulation of Oil-in-Water Nanoemulsions: Rational Design, Development, and Kinetic Stability

Amphoteric amphiphilic compounds, due to their unique properties, may represent a group of safe and biocompatible surface-active agents for effective colloidal stabilization of nanoformulations. For this reason, the aim of this work was to develop and characterize the oil-in-water nanoemulsions base...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ewelina Waglewska, Urszula Bazylińska
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	nanoformulations betaine-type surfactants mild surfactants ternary phase diagrams kinetic stability backscattered profiles Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/4edeeec3e329408e8ef1e0ad00f07ae4
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4edeeec3e329408e8ef1e0ad00f07ae4
record_format	dspace
spelling	oai:doaj.org-article:4edeeec3e329408e8ef1e0ad00f07ae42021-11-11T17:13:40ZBiodegradable Amphoteric Surfactants in Titration-Ultrasound Formulation of Oil-in-Water Nanoemulsions: Rational Design, Development, and Kinetic Stability10.3390/ijms2221117761422-00671661-6596https://doaj.org/article/4edeeec3e329408e8ef1e0ad00f07ae42021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11776https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Amphoteric amphiphilic compounds, due to their unique properties, may represent a group of safe and biocompatible surface-active agents for effective colloidal stabilization of nanoformulations. For this reason, the aim of this work was to develop and characterize the oil-in-water nanoemulsions based on two betaine-derived surfactants with high biodegradability, i.e., cocamidopropyl betaine and coco-betaine. In the first step, we investigated ternary phase diagrams of surfactant-oil-water systems containing different weight ratios of surfactant and oil, as the betaine-type surfactant entity (S), linoleic acid, or oleic acid as the oil phase (O), and the aqueous phase (W) using the titration-ultrasound approach. All the received nanoemulsion systems were then characterized upon droplets size (dynamic light scattering), surface charge (electrophoretic light scattering), and morphology (transmission electron as well as atomic force microscopy). Thermal and spinning tests revealed the most stable compositions, which were subjected to further kinetic stability analysis, including turbidimetric evaluation. Finally, the backscattering profiles revealed the most promising candidate with a size <200 nm for potential delivery of active agents in the future cosmetic, pharmaceutical, and biomedical applications.Ewelina WaglewskaUrszula BazylińskaMDPI AGarticlenanoformulationsbetaine-type surfactantsmild surfactantsternary phase diagramskinetic stabilitybackscattered profilesBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11776, p 11776 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	nanoformulations betaine-type surfactants mild surfactants ternary phase diagrams kinetic stability backscattered profiles Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	nanoformulations betaine-type surfactants mild surfactants ternary phase diagrams kinetic stability backscattered profiles Biology (General) QH301-705.5 Chemistry QD1-999 Ewelina Waglewska Urszula Bazylińska Biodegradable Amphoteric Surfactants in Titration-Ultrasound Formulation of Oil-in-Water Nanoemulsions: Rational Design, Development, and Kinetic Stability
description	Amphoteric amphiphilic compounds, due to their unique properties, may represent a group of safe and biocompatible surface-active agents for effective colloidal stabilization of nanoformulations. For this reason, the aim of this work was to develop and characterize the oil-in-water nanoemulsions based on two betaine-derived surfactants with high biodegradability, i.e., cocamidopropyl betaine and coco-betaine. In the first step, we investigated ternary phase diagrams of surfactant-oil-water systems containing different weight ratios of surfactant and oil, as the betaine-type surfactant entity (S), linoleic acid, or oleic acid as the oil phase (O), and the aqueous phase (W) using the titration-ultrasound approach. All the received nanoemulsion systems were then characterized upon droplets size (dynamic light scattering), surface charge (electrophoretic light scattering), and morphology (transmission electron as well as atomic force microscopy). Thermal and spinning tests revealed the most stable compositions, which were subjected to further kinetic stability analysis, including turbidimetric evaluation. Finally, the backscattering profiles revealed the most promising candidate with a size <200 nm for potential delivery of active agents in the future cosmetic, pharmaceutical, and biomedical applications.
format	article
author	Ewelina Waglewska Urszula Bazylińska
author_facet	Ewelina Waglewska Urszula Bazylińska
author_sort	Ewelina Waglewska
title	Biodegradable Amphoteric Surfactants in Titration-Ultrasound Formulation of Oil-in-Water Nanoemulsions: Rational Design, Development, and Kinetic Stability
title_short	Biodegradable Amphoteric Surfactants in Titration-Ultrasound Formulation of Oil-in-Water Nanoemulsions: Rational Design, Development, and Kinetic Stability
title_full	Biodegradable Amphoteric Surfactants in Titration-Ultrasound Formulation of Oil-in-Water Nanoemulsions: Rational Design, Development, and Kinetic Stability
title_fullStr	Biodegradable Amphoteric Surfactants in Titration-Ultrasound Formulation of Oil-in-Water Nanoemulsions: Rational Design, Development, and Kinetic Stability
title_full_unstemmed	Biodegradable Amphoteric Surfactants in Titration-Ultrasound Formulation of Oil-in-Water Nanoemulsions: Rational Design, Development, and Kinetic Stability
title_sort	biodegradable amphoteric surfactants in titration-ultrasound formulation of oil-in-water nanoemulsions: rational design, development, and kinetic stability
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/4edeeec3e329408e8ef1e0ad00f07ae4
work_keys_str_mv	AT ewelinawaglewska biodegradableamphotericsurfactantsintitrationultrasoundformulationofoilinwaternanoemulsionsrationaldesigndevelopmentandkineticstability AT urszulabazylinska biodegradableamphotericsurfactantsintitrationultrasoundformulationofoilinwaternanoemulsionsrationaldesigndevelopmentandkineticstability
_version_	1718432115628965888

Biodegradable Amphoteric Surfactants in Titration-Ultrasound Formulation of Oil-in-Water Nanoemulsions: Rational Design, Development, and Kinetic Stability

Ejemplares similares