Plasmonic MXene-based nanocomposites exhibiting photothermal therapeutic effects with lower acute toxicity than pure MXene

Essraa A Hussein,1 Moustafa M Zagho,1 Balsam R Rizeq,2,3 Nadin N Younes,4 Gianfranco Pintus,3,4 Khaled A Mahmoud,5 Gheyath K Nasrallah,3,4 Ahmed A Elzatahry11Materials Science and Technology Program, College of Arts and Sciences, Qatar University, Doha, Qatar; 2Department of Biological and Environme...

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Autores principales:	Hussein EA, Zagho MM, Rizeq BR, Younes NN, Pintus G, Mahmoud KA, Nasrallah GK, Elzatahry AA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	MXene • gold • magnetite • MCF7 • photothermal therapy • acute toxicity Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/4ee02ddb89734b2c8b1d051b72c54927
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spelling	oai:doaj.org-article:4ee02ddb89734b2c8b1d051b72c549272021-12-02T01:11:58ZPlasmonic MXene-based nanocomposites exhibiting photothermal therapeutic effects with lower acute toxicity than pure MXene1178-2013https://doaj.org/article/4ee02ddb89734b2c8b1d051b72c549272019-06-01T00:00:00Zhttps://www.dovepress.com/plasmonic-mxene-based-nanocomposites-exhibiting-photothermal-therapeut-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Essraa A Hussein,1 Moustafa M Zagho,1 Balsam R Rizeq,2,3 Nadin N Younes,4 Gianfranco Pintus,3,4 Khaled A Mahmoud,5 Gheyath K Nasrallah,3,4 Ahmed A Elzatahry11Materials Science and Technology Program, College of Arts and Sciences, Qatar University, Doha, Qatar; 2Department of Biological and Environmental Sciences, College of Arts and Sciences, Qatar University, Doha, Qatar; 3Biomedical Research Center, Qatar University, Doha, Qatar; 4Department of Biomedical Science, College of Health Sciences, Qatar University, Women’s Science Building, Doha, Qatar; 5Qatar Environment and Energy Research Institute (QEERI), Hamad Bin Khalifa University, Doha, QatarPurpose: Here, we fabricated two plasmonic 2D Ti3C2Tx-based nanocomposites (Au/MXene and Au/Fe3O4/MXene) with similarly high anti-cancer photothermal therapy (PTT) capabilities, but with less in vivo toxicity than a pure MXene.Methods: Au/MXene was synthesized by in situ reduction of tetrachloroauric acid using NaBH4 on Ti3C2Tx flakes. For targeted PTT, magnetic Au/Fe3O4/MXene was synthesized via a reaction between freshly prepared magnetite Fe3O4 NPs and MXene solution, followed by in situ integration of gold nanoparticles (AuNPs).Results: Morphological characterization by XRD, SEM, and TEM revealed the successful synthesis of Au/MXene and Au/Fe3O4/MXene. Both new composites exhibited a significant in vitro dose-dependent PTT effect against human breast cancer cells MCF7. Interestingly, in vivo acute toxicity assays using zebrafish embryos indicated that Au/MXene and Au/Fe3O4/MXene had less embryonic mortality (LC50 ≫ 1000 μg/mL) than pure MXene (LC50=257.46 μg/mL).Conclusion: Our new Au/MXene and Au/Fe3O4/MXene nanocomposites could be safer and more suitable than the pure MXene for biomedical applications, especially when targeted PTT is warranted.Keywords: MXene, gold, magnetite, MCF7, photothermal therapy, acute toxicityHussein EAZagho MMRizeq BRYounes NNPintus GMahmoud KANasrallah GKElzatahry AADove Medical PressarticleMXene • gold • magnetite • MCF7 • photothermal therapy • acute toxicityMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 4529-4539 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	MXene • gold • magnetite • MCF7 • photothermal therapy • acute toxicity Medicine (General) R5-920
spellingShingle	MXene • gold • magnetite • MCF7 • photothermal therapy • acute toxicity Medicine (General) R5-920 Hussein EA Zagho MM Rizeq BR Younes NN Pintus G Mahmoud KA Nasrallah GK Elzatahry AA Plasmonic MXene-based nanocomposites exhibiting photothermal therapeutic effects with lower acute toxicity than pure MXene
description	Essraa A Hussein,1 Moustafa M Zagho,1 Balsam R Rizeq,2,3 Nadin N Younes,4 Gianfranco Pintus,3,4 Khaled A Mahmoud,5 Gheyath K Nasrallah,3,4 Ahmed A Elzatahry11Materials Science and Technology Program, College of Arts and Sciences, Qatar University, Doha, Qatar; 2Department of Biological and Environmental Sciences, College of Arts and Sciences, Qatar University, Doha, Qatar; 3Biomedical Research Center, Qatar University, Doha, Qatar; 4Department of Biomedical Science, College of Health Sciences, Qatar University, Women’s Science Building, Doha, Qatar; 5Qatar Environment and Energy Research Institute (QEERI), Hamad Bin Khalifa University, Doha, QatarPurpose: Here, we fabricated two plasmonic 2D Ti3C2Tx-based nanocomposites (Au/MXene and Au/Fe3O4/MXene) with similarly high anti-cancer photothermal therapy (PTT) capabilities, but with less in vivo toxicity than a pure MXene.Methods: Au/MXene was synthesized by in situ reduction of tetrachloroauric acid using NaBH4 on Ti3C2Tx flakes. For targeted PTT, magnetic Au/Fe3O4/MXene was synthesized via a reaction between freshly prepared magnetite Fe3O4 NPs and MXene solution, followed by in situ integration of gold nanoparticles (AuNPs).Results: Morphological characterization by XRD, SEM, and TEM revealed the successful synthesis of Au/MXene and Au/Fe3O4/MXene. Both new composites exhibited a significant in vitro dose-dependent PTT effect against human breast cancer cells MCF7. Interestingly, in vivo acute toxicity assays using zebrafish embryos indicated that Au/MXene and Au/Fe3O4/MXene had less embryonic mortality (LC50 ≫ 1000 μg/mL) than pure MXene (LC50=257.46 μg/mL).Conclusion: Our new Au/MXene and Au/Fe3O4/MXene nanocomposites could be safer and more suitable than the pure MXene for biomedical applications, especially when targeted PTT is warranted.Keywords: MXene, gold, magnetite, MCF7, photothermal therapy, acute toxicity
format	article
author	Hussein EA Zagho MM Rizeq BR Younes NN Pintus G Mahmoud KA Nasrallah GK Elzatahry AA
author_facet	Hussein EA Zagho MM Rizeq BR Younes NN Pintus G Mahmoud KA Nasrallah GK Elzatahry AA
author_sort	Hussein EA
title	Plasmonic MXene-based nanocomposites exhibiting photothermal therapeutic effects with lower acute toxicity than pure MXene
title_short	Plasmonic MXene-based nanocomposites exhibiting photothermal therapeutic effects with lower acute toxicity than pure MXene
title_full	Plasmonic MXene-based nanocomposites exhibiting photothermal therapeutic effects with lower acute toxicity than pure MXene
title_fullStr	Plasmonic MXene-based nanocomposites exhibiting photothermal therapeutic effects with lower acute toxicity than pure MXene
title_full_unstemmed	Plasmonic MXene-based nanocomposites exhibiting photothermal therapeutic effects with lower acute toxicity than pure MXene
title_sort	plasmonic mxene-based nanocomposites exhibiting photothermal therapeutic effects with lower acute toxicity than pure mxene
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/4ee02ddb89734b2c8b1d051b72c54927
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Plasmonic MXene-based nanocomposites exhibiting photothermal therapeutic effects with lower acute toxicity than pure MXene

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