Anti-CRISPR-mediated control of gene editing and synthetic circuits in eukaryotic cells
Anti-CRISPR proteins derived from phage can abrogate CRISPR activity. The authors repurpose these molecules for demonstrating genomic write-protection and pre-programmed gene expression circuits.
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Nature Portfolio
2019
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oai:doaj.org-article:4ee1c4c14f3b4f9ea9f6a310629064532021-12-02T16:57:54ZAnti-CRISPR-mediated control of gene editing and synthetic circuits in eukaryotic cells10.1038/s41467-018-08158-x2041-1723https://doaj.org/article/4ee1c4c14f3b4f9ea9f6a310629064532019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08158-xhttps://doaj.org/toc/2041-1723Anti-CRISPR proteins derived from phage can abrogate CRISPR activity. The authors repurpose these molecules for demonstrating genomic write-protection and pre-programmed gene expression circuits.Muneaki NakamuraPrashanth SrinivasanMichael ChavezMatthew A. CarterAntonia A. DominguezMarie La RussaMatthew B. LauTimothy R. AbbottXiaoshu XuDehua ZhaoYuchen GaoNathan H. KipnissChristina D. SmolkeJoseph Bondy-DenomyLei S. QiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Muneaki Nakamura Prashanth Srinivasan Michael Chavez Matthew A. Carter Antonia A. Dominguez Marie La Russa Matthew B. Lau Timothy R. Abbott Xiaoshu Xu Dehua Zhao Yuchen Gao Nathan H. Kipniss Christina D. Smolke Joseph Bondy-Denomy Lei S. Qi Anti-CRISPR-mediated control of gene editing and synthetic circuits in eukaryotic cells |
| description |
Anti-CRISPR proteins derived from phage can abrogate CRISPR activity. The authors repurpose these molecules for demonstrating genomic write-protection and pre-programmed gene expression circuits. |
| format |
article |
| author |
Muneaki Nakamura Prashanth Srinivasan Michael Chavez Matthew A. Carter Antonia A. Dominguez Marie La Russa Matthew B. Lau Timothy R. Abbott Xiaoshu Xu Dehua Zhao Yuchen Gao Nathan H. Kipniss Christina D. Smolke Joseph Bondy-Denomy Lei S. Qi |
| author_facet |
Muneaki Nakamura Prashanth Srinivasan Michael Chavez Matthew A. Carter Antonia A. Dominguez Marie La Russa Matthew B. Lau Timothy R. Abbott Xiaoshu Xu Dehua Zhao Yuchen Gao Nathan H. Kipniss Christina D. Smolke Joseph Bondy-Denomy Lei S. Qi |
| author_sort |
Muneaki Nakamura |
| title |
Anti-CRISPR-mediated control of gene editing and synthetic circuits in eukaryotic cells |
| title_short |
Anti-CRISPR-mediated control of gene editing and synthetic circuits in eukaryotic cells |
| title_full |
Anti-CRISPR-mediated control of gene editing and synthetic circuits in eukaryotic cells |
| title_fullStr |
Anti-CRISPR-mediated control of gene editing and synthetic circuits in eukaryotic cells |
| title_full_unstemmed |
Anti-CRISPR-mediated control of gene editing and synthetic circuits in eukaryotic cells |
| title_sort |
anti-crispr-mediated control of gene editing and synthetic circuits in eukaryotic cells |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/4ee1c4c14f3b4f9ea9f6a31062906453 |
| work_keys_str_mv |
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1718382445193068544 |