Anti-CRISPR-mediated control of gene editing and synthetic circuits in eukaryotic cells

Anti-CRISPR-mediated control of gene editing and synthetic circuits in eukaryotic cells

Anti-CRISPR proteins derived from phage can abrogate CRISPR activity. The authors repurpose these molecules for demonstrating genomic write-protection and pre-programmed gene expression circuits.

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Bibliographic Details
Main Authors: Muneaki Nakamura, Prashanth Srinivasan, Michael Chavez, Matthew A. Carter, Antonia A. Dominguez, Marie La Russa, Matthew B. Lau, Timothy R. Abbott, Xiaoshu Xu, Dehua Zhao, Yuchen Gao, Nathan H. Kipniss, Christina D. Smolke, Joseph Bondy-Denomy, Lei S. Qi
Format: article
Language:EN
Published: Nature Portfolio 2019
Subjects:
Science
Q
Online Access:https://doaj.org/article/4ee1c4c14f3b4f9ea9f6a31062906453
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