Developmental decrease of entorhinal-hippocampal communication in immune-challenged DISC1 knockdown mice

The authors show that mice that mimic the dual genetic-environmental etiology of psychiatric risk have poor lateral entorhinal cortex-dependent recognition memory already at pre-juvenile age and abnormal communication within LECHP-PFC networks throughout development.

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Autores principales:	Xiaxia Xu, Lingzhen Song, Rebecca Kringel, Ileana L. Hanganu-Opatz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4eeaaffa270c4411b58571707c6c2adb
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spelling	oai:doaj.org-article:4eeaaffa270c4411b58571707c6c2adb2021-11-28T12:31:20ZDevelopmental decrease of entorhinal-hippocampal communication in immune-challenged DISC1 knockdown mice10.1038/s41467-021-27114-w2041-1723https://doaj.org/article/4eeaaffa270c4411b58571707c6c2adb2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27114-whttps://doaj.org/toc/2041-1723The authors show that mice that mimic the dual genetic-environmental etiology of psychiatric risk have poor lateral entorhinal cortex-dependent recognition memory already at pre-juvenile age and abnormal communication within LECHP-PFC networks throughout development.Xiaxia XuLingzhen SongRebecca KringelIleana L. Hanganu-OpatzNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiaxia Xu Lingzhen Song Rebecca Kringel Ileana L. Hanganu-Opatz Developmental decrease of entorhinal-hippocampal communication in immune-challenged DISC1 knockdown mice
description	The authors show that mice that mimic the dual genetic-environmental etiology of psychiatric risk have poor lateral entorhinal cortex-dependent recognition memory already at pre-juvenile age and abnormal communication within LECHP-PFC networks throughout development.
format	article
author	Xiaxia Xu Lingzhen Song Rebecca Kringel Ileana L. Hanganu-Opatz
author_facet	Xiaxia Xu Lingzhen Song Rebecca Kringel Ileana L. Hanganu-Opatz
author_sort	Xiaxia Xu
title	Developmental decrease of entorhinal-hippocampal communication in immune-challenged DISC1 knockdown mice
title_short	Developmental decrease of entorhinal-hippocampal communication in immune-challenged DISC1 knockdown mice
title_full	Developmental decrease of entorhinal-hippocampal communication in immune-challenged DISC1 knockdown mice
title_fullStr	Developmental decrease of entorhinal-hippocampal communication in immune-challenged DISC1 knockdown mice
title_full_unstemmed	Developmental decrease of entorhinal-hippocampal communication in immune-challenged DISC1 knockdown mice
title_sort	developmental decrease of entorhinal-hippocampal communication in immune-challenged disc1 knockdown mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4eeaaffa270c4411b58571707c6c2adb
work_keys_str_mv	AT xiaxiaxu developmentaldecreaseofentorhinalhippocampalcommunicationinimmunechallengeddisc1knockdownmice AT lingzhensong developmentaldecreaseofentorhinalhippocampalcommunicationinimmunechallengeddisc1knockdownmice AT rebeccakringel developmentaldecreaseofentorhinalhippocampalcommunicationinimmunechallengeddisc1knockdownmice AT ileanalhanganuopatz developmentaldecreaseofentorhinalhippocampalcommunicationinimmunechallengeddisc1knockdownmice
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Developmental decrease of entorhinal-hippocampal communication in immune-challenged DISC1 knockdown mice

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