Therapeutic potential of KLF2-induced exosomal microRNAs in pulmonary hypertension
Pulmonary arterial hypertension is a severe lung disease characterised by progressive vascular remodelling. Here, the authors show that reduced signalling of flow-activated transcription factor KLF2 is a common feature of human PAH and that KLF2-regulated exosomal miRNAs have a therapeutic effect.
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Nature Portfolio
2020
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oai:doaj.org-article:4eebb969beec4b25a1d7906be6c74e472021-12-02T14:40:51ZTherapeutic potential of KLF2-induced exosomal microRNAs in pulmonary hypertension10.1038/s41467-020-14966-x2041-1723https://doaj.org/article/4eebb969beec4b25a1d7906be6c74e472020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14966-xhttps://doaj.org/toc/2041-1723Pulmonary arterial hypertension is a severe lung disease characterised by progressive vascular remodelling. Here, the authors show that reduced signalling of flow-activated transcription factor KLF2 is a common feature of human PAH and that KLF2-regulated exosomal miRNAs have a therapeutic effect.Hebah A. SindiGiusy RussomannoSandro SattaVahitha B. Abdul-SalamKyeong Beom JoBasma Qazi-ChaudhryAlexander J. AinscoughRobert SzulcekHarm Jan BogaardClaire C. MorganSoni S. PullamsettiMai M. AlzaydiChristopher J. RhodesRoberto PivaChristina A. EichstaedtEkkehard GrünigMartin R. WilkinsBeata Wojciak-StothardNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020) |
| institution |
DOAJ |
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DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Hebah A. Sindi Giusy Russomanno Sandro Satta Vahitha B. Abdul-Salam Kyeong Beom Jo Basma Qazi-Chaudhry Alexander J. Ainscough Robert Szulcek Harm Jan Bogaard Claire C. Morgan Soni S. Pullamsetti Mai M. Alzaydi Christopher J. Rhodes Roberto Piva Christina A. Eichstaedt Ekkehard Grünig Martin R. Wilkins Beata Wojciak-Stothard Therapeutic potential of KLF2-induced exosomal microRNAs in pulmonary hypertension |
| description |
Pulmonary arterial hypertension is a severe lung disease characterised by progressive vascular remodelling. Here, the authors show that reduced signalling of flow-activated transcription factor KLF2 is a common feature of human PAH and that KLF2-regulated exosomal miRNAs have a therapeutic effect. |
| format |
article |
| author |
Hebah A. Sindi Giusy Russomanno Sandro Satta Vahitha B. Abdul-Salam Kyeong Beom Jo Basma Qazi-Chaudhry Alexander J. Ainscough Robert Szulcek Harm Jan Bogaard Claire C. Morgan Soni S. Pullamsetti Mai M. Alzaydi Christopher J. Rhodes Roberto Piva Christina A. Eichstaedt Ekkehard Grünig Martin R. Wilkins Beata Wojciak-Stothard |
| author_facet |
Hebah A. Sindi Giusy Russomanno Sandro Satta Vahitha B. Abdul-Salam Kyeong Beom Jo Basma Qazi-Chaudhry Alexander J. Ainscough Robert Szulcek Harm Jan Bogaard Claire C. Morgan Soni S. Pullamsetti Mai M. Alzaydi Christopher J. Rhodes Roberto Piva Christina A. Eichstaedt Ekkehard Grünig Martin R. Wilkins Beata Wojciak-Stothard |
| author_sort |
Hebah A. Sindi |
| title |
Therapeutic potential of KLF2-induced exosomal microRNAs in pulmonary hypertension |
| title_short |
Therapeutic potential of KLF2-induced exosomal microRNAs in pulmonary hypertension |
| title_full |
Therapeutic potential of KLF2-induced exosomal microRNAs in pulmonary hypertension |
| title_fullStr |
Therapeutic potential of KLF2-induced exosomal microRNAs in pulmonary hypertension |
| title_full_unstemmed |
Therapeutic potential of KLF2-induced exosomal microRNAs in pulmonary hypertension |
| title_sort |
therapeutic potential of klf2-induced exosomal micrornas in pulmonary hypertension |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/4eebb969beec4b25a1d7906be6c74e47 |
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