Soft matrices suppress cooperative behaviors among receptor-ligand bonds in cell adhesion.

The fact that biological tissues are stable over prolonged periods of time while individual receptor-ligand bonds only have limited lifetime underscores the critical importance of cooperative behaviors of multiple molecular bonds, in particular the competition between the rate of rupture of closed b...

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Autores principales:	Jin Qian, Huajian Gao
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4efc92424f404029a1791f366cd5a2eb
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spelling	oai:doaj.org-article:4efc92424f404029a1791f366cd5a2eb2021-11-18T06:35:49ZSoft matrices suppress cooperative behaviors among receptor-ligand bonds in cell adhesion.1932-620310.1371/journal.pone.0012342https://doaj.org/article/4efc92424f404029a1791f366cd5a2eb2010-08-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20808789/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203The fact that biological tissues are stable over prolonged periods of time while individual receptor-ligand bonds only have limited lifetime underscores the critical importance of cooperative behaviors of multiple molecular bonds, in particular the competition between the rate of rupture of closed bonds (death rate) and the rate of rebinding of open bonds (birth rate) in a bond cluster. We have recently shown that soft matrices can greatly increase the death rate in a bond cluster by inducing severe stress concentration near the adhesion edges. In the present paper, we report a more striking effect that, irrespective of stress concentration, soft matrices also suppress the birth rate in a bond cluster by increasing the local separation distance between open bonds. This is shown by theoretical analysis as well as Monte Carlo simulations based on a stochastic-elasticity model in which stochastic descriptions of molecular bonds and elastic descriptions of interfacial force/separation are unified in a single modeling framework. Our findings not only are important for understanding the role of elastic matrices in cell adhesion, but also have general implications on adhesion between soft materials.Jin QianHuajian GaoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 8, p e12342 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jin Qian Huajian Gao Soft matrices suppress cooperative behaviors among receptor-ligand bonds in cell adhesion.
description	The fact that biological tissues are stable over prolonged periods of time while individual receptor-ligand bonds only have limited lifetime underscores the critical importance of cooperative behaviors of multiple molecular bonds, in particular the competition between the rate of rupture of closed bonds (death rate) and the rate of rebinding of open bonds (birth rate) in a bond cluster. We have recently shown that soft matrices can greatly increase the death rate in a bond cluster by inducing severe stress concentration near the adhesion edges. In the present paper, we report a more striking effect that, irrespective of stress concentration, soft matrices also suppress the birth rate in a bond cluster by increasing the local separation distance between open bonds. This is shown by theoretical analysis as well as Monte Carlo simulations based on a stochastic-elasticity model in which stochastic descriptions of molecular bonds and elastic descriptions of interfacial force/separation are unified in a single modeling framework. Our findings not only are important for understanding the role of elastic matrices in cell adhesion, but also have general implications on adhesion between soft materials.
format	article
author	Jin Qian Huajian Gao
author_facet	Jin Qian Huajian Gao
author_sort	Jin Qian
title	Soft matrices suppress cooperative behaviors among receptor-ligand bonds in cell adhesion.
title_short	Soft matrices suppress cooperative behaviors among receptor-ligand bonds in cell adhesion.
title_full	Soft matrices suppress cooperative behaviors among receptor-ligand bonds in cell adhesion.
title_fullStr	Soft matrices suppress cooperative behaviors among receptor-ligand bonds in cell adhesion.
title_full_unstemmed	Soft matrices suppress cooperative behaviors among receptor-ligand bonds in cell adhesion.
title_sort	soft matrices suppress cooperative behaviors among receptor-ligand bonds in cell adhesion.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/4efc92424f404029a1791f366cd5a2eb
work_keys_str_mv	AT jinqian softmatricessuppresscooperativebehaviorsamongreceptorligandbondsincelladhesion AT huajiangao softmatricessuppresscooperativebehaviorsamongreceptorligandbondsincelladhesion
_version_	1718424413151428608

Soft matrices suppress cooperative behaviors among receptor-ligand bonds in cell adhesion.

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