Long-term potentiation in an innexin-based electrical synapse

Abstract Electrical synapses are formed by two unrelated gap junction protein families, the primordial innexins (invertebrates) or the connexins (vertebrates). Although molecularly different, innexin- and connexin-based electrical synapses are strikingly similar in their membrane topology. However,...

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Autores principales:	Georg Welzel, Stefan Schuster
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4f013de645224e4289d4b899b70b3d25
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spelling	oai:doaj.org-article:4f013de645224e4289d4b899b70b3d252021-12-02T15:08:50ZLong-term potentiation in an innexin-based electrical synapse10.1038/s41598-018-30966-w2045-2322https://doaj.org/article/4f013de645224e4289d4b899b70b3d252018-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-30966-whttps://doaj.org/toc/2045-2322Abstract Electrical synapses are formed by two unrelated gap junction protein families, the primordial innexins (invertebrates) or the connexins (vertebrates). Although molecularly different, innexin- and connexin-based electrical synapses are strikingly similar in their membrane topology. However, it remains unclear if this similarity extends also to more sophisticated functions such as long-term potentiation which is only known in connexin-based synapses. Here we show that this capacity is not unique to connexin-based synapses. Using a method that allowed us to quantitatively measure gap-junction conductance we provide the first and unequivocal evidence of long-term potentiation in an innexin-based electrical synapse. Our findings suggest that long-term potentiation is a property that has likely existed already in ancestral gap junctions. They therefore could provide a highly potent system to dissect shared molecular mechanisms of electrical synapse plasticity.Georg WelzelStefan SchusterNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Georg Welzel Stefan Schuster Long-term potentiation in an innexin-based electrical synapse
description	Abstract Electrical synapses are formed by two unrelated gap junction protein families, the primordial innexins (invertebrates) or the connexins (vertebrates). Although molecularly different, innexin- and connexin-based electrical synapses are strikingly similar in their membrane topology. However, it remains unclear if this similarity extends also to more sophisticated functions such as long-term potentiation which is only known in connexin-based synapses. Here we show that this capacity is not unique to connexin-based synapses. Using a method that allowed us to quantitatively measure gap-junction conductance we provide the first and unequivocal evidence of long-term potentiation in an innexin-based electrical synapse. Our findings suggest that long-term potentiation is a property that has likely existed already in ancestral gap junctions. They therefore could provide a highly potent system to dissect shared molecular mechanisms of electrical synapse plasticity.
format	article
author	Georg Welzel Stefan Schuster
author_facet	Georg Welzel Stefan Schuster
author_sort	Georg Welzel
title	Long-term potentiation in an innexin-based electrical synapse
title_short	Long-term potentiation in an innexin-based electrical synapse
title_full	Long-term potentiation in an innexin-based electrical synapse
title_fullStr	Long-term potentiation in an innexin-based electrical synapse
title_full_unstemmed	Long-term potentiation in an innexin-based electrical synapse
title_sort	long-term potentiation in an innexin-based electrical synapse
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/4f013de645224e4289d4b899b70b3d25
work_keys_str_mv	AT georgwelzel longtermpotentiationinaninnexinbasedelectricalsynapse AT stefanschuster longtermpotentiationinaninnexinbasedelectricalsynapse
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Long-term potentiation in an innexin-based electrical synapse

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