Pause sequences facilitate entry into long-lived paused states by reducing RNA polymerase transcription rates

Transcription elongation by RNA polymerase (RNAP) is interspersed with sequence-dependent pausing which is difficult to study due to spatiotemporal limitations of available methods. Here authors use a high-resolution optical tweezers assay and find that pause sites modify the dynamics of nearly all...

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Autores principales:	Ronen Gabizon, Antony Lee, Hanif Vahedian-Movahed, Richard H. Ebright, Carlos J. Bustamante
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4f02b5bce35947fabd2aa1bed87b067f
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spelling	oai:doaj.org-article:4f02b5bce35947fabd2aa1bed87b067f2021-12-02T15:33:56ZPause sequences facilitate entry into long-lived paused states by reducing RNA polymerase transcription rates10.1038/s41467-018-05344-92041-1723https://doaj.org/article/4f02b5bce35947fabd2aa1bed87b067f2018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05344-9https://doaj.org/toc/2041-1723Transcription elongation by RNA polymerase (RNAP) is interspersed with sequence-dependent pausing which is difficult to study due to spatiotemporal limitations of available methods. Here authors use a high-resolution optical tweezers assay and find that pause sites modify the dynamics of nearly all RNAP molecules.Ronen GabizonAntony LeeHanif Vahedian-MovahedRichard H. EbrightCarlos J. BustamanteNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ronen Gabizon Antony Lee Hanif Vahedian-Movahed Richard H. Ebright Carlos J. Bustamante Pause sequences facilitate entry into long-lived paused states by reducing RNA polymerase transcription rates
description	Transcription elongation by RNA polymerase (RNAP) is interspersed with sequence-dependent pausing which is difficult to study due to spatiotemporal limitations of available methods. Here authors use a high-resolution optical tweezers assay and find that pause sites modify the dynamics of nearly all RNAP molecules.
format	article
author	Ronen Gabizon Antony Lee Hanif Vahedian-Movahed Richard H. Ebright Carlos J. Bustamante
author_facet	Ronen Gabizon Antony Lee Hanif Vahedian-Movahed Richard H. Ebright Carlos J. Bustamante
author_sort	Ronen Gabizon
title	Pause sequences facilitate entry into long-lived paused states by reducing RNA polymerase transcription rates
title_short	Pause sequences facilitate entry into long-lived paused states by reducing RNA polymerase transcription rates
title_full	Pause sequences facilitate entry into long-lived paused states by reducing RNA polymerase transcription rates
title_fullStr	Pause sequences facilitate entry into long-lived paused states by reducing RNA polymerase transcription rates
title_full_unstemmed	Pause sequences facilitate entry into long-lived paused states by reducing RNA polymerase transcription rates
title_sort	pause sequences facilitate entry into long-lived paused states by reducing rna polymerase transcription rates
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/4f02b5bce35947fabd2aa1bed87b067f
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Pause sequences facilitate entry into long-lived paused states by reducing RNA polymerase transcription rates

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