Influenza infection as a trigger for systemic lupus erythematosus flares resulting in hospitalization

Abstract In patients with systemic lupus erythematosus (SLE), there are concerns that infections may increase the risk of flares. We evaluated the association between influenza infection and SLE flares resulting in hospitalization. SLE flares resulting in hospitalization and influenza cases were asc...

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Autores principales:	Young Bin Joo, Ki-Jo Kim, Kyung-Su Park, Yune-Jung Park
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4f0562900ecb44fdb59f0aaa68d672b1
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spelling	oai:doaj.org-article:4f0562900ecb44fdb59f0aaa68d672b12021-12-02T13:19:31ZInfluenza infection as a trigger for systemic lupus erythematosus flares resulting in hospitalization10.1038/s41598-021-84153-52045-2322https://doaj.org/article/4f0562900ecb44fdb59f0aaa68d672b12021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84153-5https://doaj.org/toc/2045-2322Abstract In patients with systemic lupus erythematosus (SLE), there are concerns that infections may increase the risk of flares. We evaluated the association between influenza infection and SLE flares resulting in hospitalization. SLE flares resulting in hospitalization and influenza cases were ascertained from the Korean national healthcare insurance database (2014–2018). We used a self-controlled case series design. We defined the risk interval as the first 7 days after the influenza index date and the control interval was defined as all other times during the observation period of each year. We estimated the incidence rates of SLE flares resulting in hospitalization during the risk interval and control interval and compared them using a Poisson regression model. We identified 1624 influenza infections among the 1455 patients with SLE. Among those, there were 98 flares in 79 patients with SLE. The incidence ratio (IR) for flares during the risk interval as compared with the control interval was 25.75 (95% confidence interval 17.63–37.59). This significantly increased the IRs for flares during the risk interval in both women (IR 27.65) and men (IR 15.30), all age groups (IR 17.00–37.84), with and without immunosuppressive agent (IR 24.29 and 28.45, respectively), and with and without prior respiratory diseases (IR 21.86 and 26.82, respectively). We found significant association between influenza infection and SLE flares resulting in hospitalization. Influenza infection has to be considered as a risk factor for flares in all SLE patients regardless of age, sex, medications, and comorbidities.Young Bin JooKi-Jo KimKyung-Su ParkYune-Jung ParkNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Young Bin Joo Ki-Jo Kim Kyung-Su Park Yune-Jung Park Influenza infection as a trigger for systemic lupus erythematosus flares resulting in hospitalization
description	Abstract In patients with systemic lupus erythematosus (SLE), there are concerns that infections may increase the risk of flares. We evaluated the association between influenza infection and SLE flares resulting in hospitalization. SLE flares resulting in hospitalization and influenza cases were ascertained from the Korean national healthcare insurance database (2014–2018). We used a self-controlled case series design. We defined the risk interval as the first 7 days after the influenza index date and the control interval was defined as all other times during the observation period of each year. We estimated the incidence rates of SLE flares resulting in hospitalization during the risk interval and control interval and compared them using a Poisson regression model. We identified 1624 influenza infections among the 1455 patients with SLE. Among those, there were 98 flares in 79 patients with SLE. The incidence ratio (IR) for flares during the risk interval as compared with the control interval was 25.75 (95% confidence interval 17.63–37.59). This significantly increased the IRs for flares during the risk interval in both women (IR 27.65) and men (IR 15.30), all age groups (IR 17.00–37.84), with and without immunosuppressive agent (IR 24.29 and 28.45, respectively), and with and without prior respiratory diseases (IR 21.86 and 26.82, respectively). We found significant association between influenza infection and SLE flares resulting in hospitalization. Influenza infection has to be considered as a risk factor for flares in all SLE patients regardless of age, sex, medications, and comorbidities.
format	article
author	Young Bin Joo Ki-Jo Kim Kyung-Su Park Yune-Jung Park
author_facet	Young Bin Joo Ki-Jo Kim Kyung-Su Park Yune-Jung Park
author_sort	Young Bin Joo
title	Influenza infection as a trigger for systemic lupus erythematosus flares resulting in hospitalization
title_short	Influenza infection as a trigger for systemic lupus erythematosus flares resulting in hospitalization
title_full	Influenza infection as a trigger for systemic lupus erythematosus flares resulting in hospitalization
title_fullStr	Influenza infection as a trigger for systemic lupus erythematosus flares resulting in hospitalization
title_full_unstemmed	Influenza infection as a trigger for systemic lupus erythematosus flares resulting in hospitalization
title_sort	influenza infection as a trigger for systemic lupus erythematosus flares resulting in hospitalization
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4f0562900ecb44fdb59f0aaa68d672b1
work_keys_str_mv	AT youngbinjoo influenzainfectionasatriggerforsystemiclupuserythematosusflaresresultinginhospitalization AT kijokim influenzainfectionasatriggerforsystemiclupuserythematosusflaresresultinginhospitalization AT kyungsupark influenzainfectionasatriggerforsystemiclupuserythematosusflaresresultinginhospitalization AT yunejungpark influenzainfectionasatriggerforsystemiclupuserythematosusflaresresultinginhospitalization
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Influenza infection as a trigger for systemic lupus erythematosus flares resulting in hospitalization

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