Genetic epidemiology of tuberculosis susceptibility: impact of study design.

Several candidate gene studies have provided evidence for a role of host genetics in susceptibility to tuberculosis (TB). However, the results of these studies have been very inconsistent, even within a study population. Here, we review the design of these studies from a genetic epidemiological pers...

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Autor principal:	Catherine M Stein
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/4f060d22c67a47719511d29a1a72d1bf
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spelling	oai:doaj.org-article:4f060d22c67a47719511d29a1a72d1bf2021-11-18T06:03:40ZGenetic epidemiology of tuberculosis susceptibility: impact of study design.1553-73661553-737410.1371/journal.ppat.1001189https://doaj.org/article/4f060d22c67a47719511d29a1a72d1bf2011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21283783/pdf/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374Several candidate gene studies have provided evidence for a role of host genetics in susceptibility to tuberculosis (TB). However, the results of these studies have been very inconsistent, even within a study population. Here, we review the design of these studies from a genetic epidemiological perspective, illustrating important differences in phenotype definition in both cases and controls, consideration of latent M. tuberculosis infection versus active TB disease, population genetic factors such as population substructure and linkage disequilibrium, polymorphism selection, and potential global differences in M. tuberculosis strain. These considerable differences between studies should be accounted for when examining the current literature. Recommendations are made for future studies to further clarify the host genetics of TB.Catherine M SteinPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 7, Iss 1, p e1001189 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Catherine M Stein Genetic epidemiology of tuberculosis susceptibility: impact of study design.
description	Several candidate gene studies have provided evidence for a role of host genetics in susceptibility to tuberculosis (TB). However, the results of these studies have been very inconsistent, even within a study population. Here, we review the design of these studies from a genetic epidemiological perspective, illustrating important differences in phenotype definition in both cases and controls, consideration of latent M. tuberculosis infection versus active TB disease, population genetic factors such as population substructure and linkage disequilibrium, polymorphism selection, and potential global differences in M. tuberculosis strain. These considerable differences between studies should be accounted for when examining the current literature. Recommendations are made for future studies to further clarify the host genetics of TB.
format	article
author	Catherine M Stein
author_facet	Catherine M Stein
author_sort	Catherine M Stein
title	Genetic epidemiology of tuberculosis susceptibility: impact of study design.
title_short	Genetic epidemiology of tuberculosis susceptibility: impact of study design.
title_full	Genetic epidemiology of tuberculosis susceptibility: impact of study design.
title_fullStr	Genetic epidemiology of tuberculosis susceptibility: impact of study design.
title_full_unstemmed	Genetic epidemiology of tuberculosis susceptibility: impact of study design.
title_sort	genetic epidemiology of tuberculosis susceptibility: impact of study design.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/4f060d22c67a47719511d29a1a72d1bf
work_keys_str_mv	AT catherinemstein geneticepidemiologyoftuberculosissusceptibilityimpactofstudydesign
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Genetic epidemiology of tuberculosis susceptibility: impact of study design.

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