Drosha drives the formation of DNA:RNA hybrids around DNA break sites to facilitate DNA repair

Drosha drives the formation of DNA:RNA hybrids around DNA break sites to facilitate DNA repair

The mechanism through which Drosha and Dicer affect DNA repair is not clear. Here the authors use a high-throughput approach to uncover the role of Drosha in promoting DNA:RNA hybrids at DNA damaged sites.

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Detalles Bibliográficos
Autores principales: Wei-Ting Lu, Ben R. Hawley, George L. Skalka, Robert A. Baldock, Ewan M. Smith, Aldo S. Bader, Michal Malewicz, Felicity Z. Watts, Ania Wilczynska, Martin Bushell
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Science
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Acceso en línea:https://doaj.org/article/4f06c76c0d594080bebcce6e6a2b7046
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Descripción
Sumario:The mechanism through which Drosha and Dicer affect DNA repair is not clear. Here the authors use a high-throughput approach to uncover the role of Drosha in promoting DNA:RNA hybrids at DNA damaged sites.

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