Meta-analysis of the effect of the pringle maneuver on long-term oncological outcomes following liver resection

Abstract Hepatic pedicle clamping reduces intraoperative blood loss and the need for transfusion, but its long-term effect on survival and recurrence remains controversial. The aim of this meta-analysis was to evaluate the effect of the Pringle maneuver (PM) on long-term oncological outcomes in pati...

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Autores principales:	Elias Khajeh, Saeed Shafiei, Sadeq Ali-Hasan Al-Saegh, Ali Ramouz, Ahmed Hammad, Omid Ghamarnejad, Mohammed Al-Saeedi, Nuh Rahbari, Christoph Reissfelder, Arianeb Mehrabi, Pascal Probst, Hani Oweira
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4f0727fe64d542f5bc3ac9a8a8b48fb5
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spelling	oai:doaj.org-article:4f0727fe64d542f5bc3ac9a8a8b48fb52021-12-02T14:26:55ZMeta-analysis of the effect of the pringle maneuver on long-term oncological outcomes following liver resection10.1038/s41598-021-82291-42045-2322https://doaj.org/article/4f0727fe64d542f5bc3ac9a8a8b48fb52021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82291-4https://doaj.org/toc/2045-2322Abstract Hepatic pedicle clamping reduces intraoperative blood loss and the need for transfusion, but its long-term effect on survival and recurrence remains controversial. The aim of this meta-analysis was to evaluate the effect of the Pringle maneuver (PM) on long-term oncological outcomes in patients with primary or metastatic liver malignancies who underwent liver resection. Literature was searched in the Cochrane Central Register of Controlled Trials (CENTRAL), Medline (via PubMed), and Web of Science databases. Survival was measured as the survival rate or as a continuous endpoint. Pooled estimates were represented as odds ratios (ORs) using the Mantel–Haenszel test with a random-effects model. The literature search retrieved 435 studies. One RCT and 18 NRS, including 7480 patients who underwent liver resection with the PM (4309 cases) or without the PM (3171 cases) were included. The PM did not decrease the 1-year overall survival rate (OR 0.86; 95% CI 0.67–1.09; P = 0.22) or the 3- and 5-year overall survival rates. The PM did not decrease the 1-year recurrence-free survival rate (OR 1.06; 95% CI 0.75–1.50; P = 0.75) or the 3- and 5-year recurrence-free survival rates. There is no evidence that the Pringle maneuver has a negative effect on recurrence-free or overall survival rates.Elias KhajehSaeed ShafieiSadeq Ali-Hasan Al-SaeghAli RamouzAhmed HammadOmid GhamarnejadMohammed Al-SaeediNuh RahbariChristoph ReissfelderArianeb MehrabiPascal ProbstHani OweiraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Elias Khajeh Saeed Shafiei Sadeq Ali-Hasan Al-Saegh Ali Ramouz Ahmed Hammad Omid Ghamarnejad Mohammed Al-Saeedi Nuh Rahbari Christoph Reissfelder Arianeb Mehrabi Pascal Probst Hani Oweira Meta-analysis of the effect of the pringle maneuver on long-term oncological outcomes following liver resection
description	Abstract Hepatic pedicle clamping reduces intraoperative blood loss and the need for transfusion, but its long-term effect on survival and recurrence remains controversial. The aim of this meta-analysis was to evaluate the effect of the Pringle maneuver (PM) on long-term oncological outcomes in patients with primary or metastatic liver malignancies who underwent liver resection. Literature was searched in the Cochrane Central Register of Controlled Trials (CENTRAL), Medline (via PubMed), and Web of Science databases. Survival was measured as the survival rate or as a continuous endpoint. Pooled estimates were represented as odds ratios (ORs) using the Mantel–Haenszel test with a random-effects model. The literature search retrieved 435 studies. One RCT and 18 NRS, including 7480 patients who underwent liver resection with the PM (4309 cases) or without the PM (3171 cases) were included. The PM did not decrease the 1-year overall survival rate (OR 0.86; 95% CI 0.67–1.09; P = 0.22) or the 3- and 5-year overall survival rates. The PM did not decrease the 1-year recurrence-free survival rate (OR 1.06; 95% CI 0.75–1.50; P = 0.75) or the 3- and 5-year recurrence-free survival rates. There is no evidence that the Pringle maneuver has a negative effect on recurrence-free or overall survival rates.
format	article
author	Elias Khajeh Saeed Shafiei Sadeq Ali-Hasan Al-Saegh Ali Ramouz Ahmed Hammad Omid Ghamarnejad Mohammed Al-Saeedi Nuh Rahbari Christoph Reissfelder Arianeb Mehrabi Pascal Probst Hani Oweira
author_facet	Elias Khajeh Saeed Shafiei Sadeq Ali-Hasan Al-Saegh Ali Ramouz Ahmed Hammad Omid Ghamarnejad Mohammed Al-Saeedi Nuh Rahbari Christoph Reissfelder Arianeb Mehrabi Pascal Probst Hani Oweira
author_sort	Elias Khajeh
title	Meta-analysis of the effect of the pringle maneuver on long-term oncological outcomes following liver resection
title_short	Meta-analysis of the effect of the pringle maneuver on long-term oncological outcomes following liver resection
title_full	Meta-analysis of the effect of the pringle maneuver on long-term oncological outcomes following liver resection
title_fullStr	Meta-analysis of the effect of the pringle maneuver on long-term oncological outcomes following liver resection
title_full_unstemmed	Meta-analysis of the effect of the pringle maneuver on long-term oncological outcomes following liver resection
title_sort	meta-analysis of the effect of the pringle maneuver on long-term oncological outcomes following liver resection
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4f0727fe64d542f5bc3ac9a8a8b48fb5
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Meta-analysis of the effect of the pringle maneuver on long-term oncological outcomes following liver resection

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