NOTCH1 is a mechanosensor in adult arteries

The arterial wall is subjected to mechanical forces that modulate endothelial cell responses. Here, Mack and colleagues identify a novel role for Notch1 as a mechanosensor in adult arteries, where it ensures junctional integrity through modulation of calcium signalling and limits atherosclerosis.

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Autores principales:	Julia J. Mack, Thiago S. Mosqueiro, Brian J. Archer, William M. Jones, Hannah Sunshine, Guido C. Faas, Anais Briot, Raquel L. Aragón, Trent Su, Milagros C. Romay, Austin I. McDonald, Cheng-Hsiang Kuo, Carlos O. Lizama, Timothy F. Lane, Ann C. Zovein, Yun Fang, Elizabeth J. Tarling, Thomas Q. de Aguiar Vallim, Mohamad Navab, Alan M. Fogelman, Louis S. Bouchard, M. Luisa Iruela-Arispe
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4f0c26b8468d4646bb1e62081f693165
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spelling	oai:doaj.org-article:4f0c26b8468d4646bb1e62081f6931652021-12-02T17:06:31ZNOTCH1 is a mechanosensor in adult arteries10.1038/s41467-017-01741-82041-1723https://doaj.org/article/4f0c26b8468d4646bb1e62081f6931652017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01741-8https://doaj.org/toc/2041-1723The arterial wall is subjected to mechanical forces that modulate endothelial cell responses. Here, Mack and colleagues identify a novel role for Notch1 as a mechanosensor in adult arteries, where it ensures junctional integrity through modulation of calcium signalling and limits atherosclerosis.Julia J. MackThiago S. MosqueiroBrian J. ArcherWilliam M. JonesHannah SunshineGuido C. FaasAnais BriotRaquel L. AragónTrent SuMilagros C. RomayAustin I. McDonaldCheng-Hsiang KuoCarlos O. LizamaTimothy F. LaneAnn C. ZoveinYun FangElizabeth J. TarlingThomas Q. de Aguiar VallimMohamad NavabAlan M. FogelmanLouis S. BouchardM. Luisa Iruela-ArispeNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-19 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Julia J. Mack Thiago S. Mosqueiro Brian J. Archer William M. Jones Hannah Sunshine Guido C. Faas Anais Briot Raquel L. Aragón Trent Su Milagros C. Romay Austin I. McDonald Cheng-Hsiang Kuo Carlos O. Lizama Timothy F. Lane Ann C. Zovein Yun Fang Elizabeth J. Tarling Thomas Q. de Aguiar Vallim Mohamad Navab Alan M. Fogelman Louis S. Bouchard M. Luisa Iruela-Arispe NOTCH1 is a mechanosensor in adult arteries
description	The arterial wall is subjected to mechanical forces that modulate endothelial cell responses. Here, Mack and colleagues identify a novel role for Notch1 as a mechanosensor in adult arteries, where it ensures junctional integrity through modulation of calcium signalling and limits atherosclerosis.
format	article
author	Julia J. Mack Thiago S. Mosqueiro Brian J. Archer William M. Jones Hannah Sunshine Guido C. Faas Anais Briot Raquel L. Aragón Trent Su Milagros C. Romay Austin I. McDonald Cheng-Hsiang Kuo Carlos O. Lizama Timothy F. Lane Ann C. Zovein Yun Fang Elizabeth J. Tarling Thomas Q. de Aguiar Vallim Mohamad Navab Alan M. Fogelman Louis S. Bouchard M. Luisa Iruela-Arispe
author_facet	Julia J. Mack Thiago S. Mosqueiro Brian J. Archer William M. Jones Hannah Sunshine Guido C. Faas Anais Briot Raquel L. Aragón Trent Su Milagros C. Romay Austin I. McDonald Cheng-Hsiang Kuo Carlos O. Lizama Timothy F. Lane Ann C. Zovein Yun Fang Elizabeth J. Tarling Thomas Q. de Aguiar Vallim Mohamad Navab Alan M. Fogelman Louis S. Bouchard M. Luisa Iruela-Arispe
author_sort	Julia J. Mack
title	NOTCH1 is a mechanosensor in adult arteries
title_short	NOTCH1 is a mechanosensor in adult arteries
title_full	NOTCH1 is a mechanosensor in adult arteries
title_fullStr	NOTCH1 is a mechanosensor in adult arteries
title_full_unstemmed	NOTCH1 is a mechanosensor in adult arteries
title_sort	notch1 is a mechanosensor in adult arteries
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/4f0c26b8468d4646bb1e62081f693165
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NOTCH1 is a mechanosensor in adult arteries

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