Bioresorbable scaffolds in the treatment of coronary artery disease

Yaojun Zhang,1,2 Christos V Bourantas,1 Vasim Farooq,1 Takashi Muramatsu,1 Roberto Diletti,1 Yoshinobu Onuma,1 Hector M Garcia-Garcia,1 Patrick W Serruys11Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands; 2Division of Cardiovascular Diseases, Nanjing First Hospital, Nanjing Medical U...

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Autores principales:	Zhang Y, Bourantas CV, Farooq V, Muramatsu T, Diletti R, Onuma Y, Garcia-Garcia HM, Serruys PW
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/4f122a2369c84d77acbf934bc12845c2
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spelling	oai:doaj.org-article:4f122a2369c84d77acbf934bc12845c22021-12-02T02:27:31ZBioresorbable scaffolds in the treatment of coronary artery disease1179-1470https://doaj.org/article/4f122a2369c84d77acbf934bc12845c22013-03-01T00:00:00Zhttp://www.dovepress.com/bioresorbable-scaffolds-in-the-treatment-of-coronary-artery-disease-a12445https://doaj.org/toc/1179-1470Yaojun Zhang,1,2 Christos V Bourantas,1 Vasim Farooq,1 Takashi Muramatsu,1 Roberto Diletti,1 Yoshinobu Onuma,1 Hector M Garcia-Garcia,1 Patrick W Serruys11Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands; 2Division of Cardiovascular Diseases, Nanjing First Hospital, Nanjing Medical University, Nanjing, People&#39;s Republic of ChinaAbstract: Drug-eluting stents have reduced the risk of in-stent restenosis and have broadened the application in percutaneous coronary intervention in coronary artery disease. However, the concept of using a permanent metallic endovascular device to restore the patency of a stenotic artery has inherited pitfalls, namely the presence of a foreign body within the artery causing vascular inflammation, late complications such as restenosis and stent thrombosis, and impeding the restoration of the physiologic function of the stented segment. Bioresorbable scaffolds (BRS) were introduced to potentially overcome these limitations, as they provide temporary scaffolding and then disappear, liberating the treated vessel from its cage. Currently, several BRSs are available, undergoing evaluation either in clinical trials or in preclinical settings. The aim of this review is to present the new developments in BRS technology, describe the mechanisms involved in the resorption process, and discuss the potential future prospects of this innovative therapy.Keywords: bioresorbable scaffold, drug-eluting stent, biodegradable, design, mechanism, coronary artery diseaseZhang YBourantas CVFarooq VMuramatsu TDiletti ROnuma YGarcia-Garcia HMSerruys PWDove Medical PressarticleMedical technologyR855-855.5ENMedical Devices: Evidence and Research, Vol 2013, Iss default, Pp 37-48 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medical technology R855-855.5
spellingShingle	Medical technology R855-855.5 Zhang Y Bourantas CV Farooq V Muramatsu T Diletti R Onuma Y Garcia-Garcia HM Serruys PW Bioresorbable scaffolds in the treatment of coronary artery disease
description	Yaojun Zhang,1,2 Christos V Bourantas,1 Vasim Farooq,1 Takashi Muramatsu,1 Roberto Diletti,1 Yoshinobu Onuma,1 Hector M Garcia-Garcia,1 Patrick W Serruys11Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands; 2Division of Cardiovascular Diseases, Nanjing First Hospital, Nanjing Medical University, Nanjing, People&#39;s Republic of ChinaAbstract: Drug-eluting stents have reduced the risk of in-stent restenosis and have broadened the application in percutaneous coronary intervention in coronary artery disease. However, the concept of using a permanent metallic endovascular device to restore the patency of a stenotic artery has inherited pitfalls, namely the presence of a foreign body within the artery causing vascular inflammation, late complications such as restenosis and stent thrombosis, and impeding the restoration of the physiologic function of the stented segment. Bioresorbable scaffolds (BRS) were introduced to potentially overcome these limitations, as they provide temporary scaffolding and then disappear, liberating the treated vessel from its cage. Currently, several BRSs are available, undergoing evaluation either in clinical trials or in preclinical settings. The aim of this review is to present the new developments in BRS technology, describe the mechanisms involved in the resorption process, and discuss the potential future prospects of this innovative therapy.Keywords: bioresorbable scaffold, drug-eluting stent, biodegradable, design, mechanism, coronary artery disease
format	article
author	Zhang Y Bourantas CV Farooq V Muramatsu T Diletti R Onuma Y Garcia-Garcia HM Serruys PW
author_facet	Zhang Y Bourantas CV Farooq V Muramatsu T Diletti R Onuma Y Garcia-Garcia HM Serruys PW
author_sort	Zhang Y
title	Bioresorbable scaffolds in the treatment of coronary artery disease
title_short	Bioresorbable scaffolds in the treatment of coronary artery disease
title_full	Bioresorbable scaffolds in the treatment of coronary artery disease
title_fullStr	Bioresorbable scaffolds in the treatment of coronary artery disease
title_full_unstemmed	Bioresorbable scaffolds in the treatment of coronary artery disease
title_sort	bioresorbable scaffolds in the treatment of coronary artery disease
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/4f122a2369c84d77acbf934bc12845c2
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Bioresorbable scaffolds in the treatment of coronary artery disease

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