Prognostic Difference of Pleural versus Distant Metastasis after Surgery for Lung Cancer

Background: Pleural metastasis in lung cancer found at diagnosis has a poor prognosis, with 5–11 months’ survival. We hypothesized that prognosis might be different for patients who have had curative-intent surgery and subsequent pleural recurrence and that survival might differ based on the locatio...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Kyla D. Joubert, Olugbenga T. Okusanya, Summer Mazur, John P. Ryan, Chigozirim N. Ekeke, Matthew J. Schuchert, Adam C. Soloff, Rajeev Dhupar
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	malignant pleural effusion metastases lung cancer surgery lobectomy lung cancer survival Medicine R
Acceso en línea:	https://doaj.org/article/4f134b676ced43adb11ac42ef423e1e0
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4f134b676ced43adb11ac42ef423e1e0
record_format	dspace
spelling	oai:doaj.org-article:4f134b676ced43adb11ac42ef423e1e02021-11-11T17:30:56ZPrognostic Difference of Pleural versus Distant Metastasis after Surgery for Lung Cancer10.3390/jcm102148462077-0383https://doaj.org/article/4f134b676ced43adb11ac42ef423e1e02021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/4846https://doaj.org/toc/2077-0383Background: Pleural metastasis in lung cancer found at diagnosis has a poor prognosis, with 5–11 months’ survival. We hypothesized that prognosis might be different for patients who have had curative-intent surgery and subsequent pleural recurrence and that survival might differ based on the location of the first metastasis (distant versus pleural). This may clarify if pleural recurrence is a local event or due to systemic disease. Methods: A database of 5089 patients who underwent curative-intent surgery for lung cancer was queried, and 85 patients were found who had biopsy-proven pleural metastasis during surveillance. We examined survival based on pattern of metastasis (pleural first versus distant first/simultaneously). Results: Median survival was 34 months (range: 1–171) from the time of surgery and 13 months (range: 0–153) from the time of recurrence. The shortest median survival after recurrence was in patients with adenocarcinoma and pleural metastasis as the first site (6 months). For patients with pleural metastasis as the first site, those with adenocarcinoma had a significantly shorter post-recurrence survival when compared with squamous cell carcinoma (6 vs. 12 months; HR = 0.34) and a significantly shorter survival from the time of surgery when compared with distant metastases first/simultaneously (25 vs. 52 months; HR = 0.49). Conclusions: Patients who undergo curative-intent surgery for lung adenocarcinoma that have pleural recurrence as the first site have poor survival. This may indicate that pleural recurrence after lung surgery is not likely due to a localized event but rather indicates systemic disease; however, this would require further study.Kyla D. JoubertOlugbenga T. OkusanyaSummer MazurJohn P. RyanChigozirim N. EkekeMatthew J. SchuchertAdam C. SoloffRajeev DhuparMDPI AGarticlemalignant pleural effusionmetastaseslung cancer surgerylobectomylung cancer survivalMedicineRENJournal of Clinical Medicine, Vol 10, Iss 4846, p 4846 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	malignant pleural effusion metastases lung cancer surgery lobectomy lung cancer survival Medicine R
spellingShingle	malignant pleural effusion metastases lung cancer surgery lobectomy lung cancer survival Medicine R Kyla D. Joubert Olugbenga T. Okusanya Summer Mazur John P. Ryan Chigozirim N. Ekeke Matthew J. Schuchert Adam C. Soloff Rajeev Dhupar Prognostic Difference of Pleural versus Distant Metastasis after Surgery for Lung Cancer
description	Background: Pleural metastasis in lung cancer found at diagnosis has a poor prognosis, with 5–11 months’ survival. We hypothesized that prognosis might be different for patients who have had curative-intent surgery and subsequent pleural recurrence and that survival might differ based on the location of the first metastasis (distant versus pleural). This may clarify if pleural recurrence is a local event or due to systemic disease. Methods: A database of 5089 patients who underwent curative-intent surgery for lung cancer was queried, and 85 patients were found who had biopsy-proven pleural metastasis during surveillance. We examined survival based on pattern of metastasis (pleural first versus distant first/simultaneously). Results: Median survival was 34 months (range: 1–171) from the time of surgery and 13 months (range: 0–153) from the time of recurrence. The shortest median survival after recurrence was in patients with adenocarcinoma and pleural metastasis as the first site (6 months). For patients with pleural metastasis as the first site, those with adenocarcinoma had a significantly shorter post-recurrence survival when compared with squamous cell carcinoma (6 vs. 12 months; HR = 0.34) and a significantly shorter survival from the time of surgery when compared with distant metastases first/simultaneously (25 vs. 52 months; HR = 0.49). Conclusions: Patients who undergo curative-intent surgery for lung adenocarcinoma that have pleural recurrence as the first site have poor survival. This may indicate that pleural recurrence after lung surgery is not likely due to a localized event but rather indicates systemic disease; however, this would require further study.
format	article
author	Kyla D. Joubert Olugbenga T. Okusanya Summer Mazur John P. Ryan Chigozirim N. Ekeke Matthew J. Schuchert Adam C. Soloff Rajeev Dhupar
author_facet	Kyla D. Joubert Olugbenga T. Okusanya Summer Mazur John P. Ryan Chigozirim N. Ekeke Matthew J. Schuchert Adam C. Soloff Rajeev Dhupar
author_sort	Kyla D. Joubert
title	Prognostic Difference of Pleural versus Distant Metastasis after Surgery for Lung Cancer
title_short	Prognostic Difference of Pleural versus Distant Metastasis after Surgery for Lung Cancer
title_full	Prognostic Difference of Pleural versus Distant Metastasis after Surgery for Lung Cancer
title_fullStr	Prognostic Difference of Pleural versus Distant Metastasis after Surgery for Lung Cancer
title_full_unstemmed	Prognostic Difference of Pleural versus Distant Metastasis after Surgery for Lung Cancer
title_sort	prognostic difference of pleural versus distant metastasis after surgery for lung cancer
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/4f134b676ced43adb11ac42ef423e1e0
work_keys_str_mv	AT kyladjoubert prognosticdifferenceofpleuralversusdistantmetastasisaftersurgeryforlungcancer AT olugbengatokusanya prognosticdifferenceofpleuralversusdistantmetastasisaftersurgeryforlungcancer AT summermazur prognosticdifferenceofpleuralversusdistantmetastasisaftersurgeryforlungcancer AT johnpryan prognosticdifferenceofpleuralversusdistantmetastasisaftersurgeryforlungcancer AT chigozirimnekeke prognosticdifferenceofpleuralversusdistantmetastasisaftersurgeryforlungcancer AT matthewjschuchert prognosticdifferenceofpleuralversusdistantmetastasisaftersurgeryforlungcancer AT adamcsoloff prognosticdifferenceofpleuralversusdistantmetastasisaftersurgeryforlungcancer AT rajeevdhupar prognosticdifferenceofpleuralversusdistantmetastasisaftersurgeryforlungcancer
_version_	1718432061882105856

Prognostic Difference of Pleural versus Distant Metastasis after Surgery for Lung Cancer

Ejemplares similares