Mesenchymal stem cell exosomes: a two-edged sword in cancer therapy

Faezeh Vakhshiteh,1 Fatemeh Atyabi,1,2 Seyed Nasser Ostad3 1Nanotechnology Research Centre, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran; 2Department of Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran; 3Department o...

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Autores principales:	Vakhshiteh F, Atyabi F, Ostad SN
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	MSCs exosome drug delivery exosome engineering cancer therapy Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/4f1417b178074980adf2bfc36caa648b
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spelling	oai:doaj.org-article:4f1417b178074980adf2bfc36caa648b2021-12-02T04:23:00ZMesenchymal stem cell exosomes: a two-edged sword in cancer therapy1178-2013https://doaj.org/article/4f1417b178074980adf2bfc36caa648b2019-04-01T00:00:00Zhttps://www.dovepress.com/mesenchymal-stem-cell-exosomes-a-two-edged-sword-in-cancer-therapy-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Faezeh Vakhshiteh,1 Fatemeh Atyabi,1,2 Seyed Nasser Ostad3 1Nanotechnology Research Centre, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran; 2Department of Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran; 3Department of Toxicology & Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran Abstract: Mesenchymal stem cells (MSCs) are multipotent stromal cells present in various adult tissues. Several studies suggest that MSCs secrete exosomes that perform as mediators in the tumor niche and play several roles in tumorigenesis, angiogenesis, and metastasis. In contrast, there are other studies supporting the tumor-suppressing effects of MSC-derived exosomes. Therefore, the exact association of MSC exosomes and tumor cells remains open to debate. This review aimed to demonstrate the present knowledge of MSC-derived exosomes in cancer research and to illustrate current approaches to make use of modified exosomes as a platform in therapeutic strategies in cancer. Keywords: mesenchymal stem cells, exosome, drug delivery, exosome engineering, cancer therapyVakhshiteh FAtyabi FOstad SNDove Medical PressarticleMSCsexosomedrug deliveryexosome engineeringcancer therapyMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 2847-2859 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	MSCs exosome drug delivery exosome engineering cancer therapy Medicine (General) R5-920
spellingShingle	MSCs exosome drug delivery exosome engineering cancer therapy Medicine (General) R5-920 Vakhshiteh F Atyabi F Ostad SN Mesenchymal stem cell exosomes: a two-edged sword in cancer therapy
description	Faezeh Vakhshiteh,1 Fatemeh Atyabi,1,2 Seyed Nasser Ostad3 1Nanotechnology Research Centre, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran; 2Department of Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran; 3Department of Toxicology & Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran Abstract: Mesenchymal stem cells (MSCs) are multipotent stromal cells present in various adult tissues. Several studies suggest that MSCs secrete exosomes that perform as mediators in the tumor niche and play several roles in tumorigenesis, angiogenesis, and metastasis. In contrast, there are other studies supporting the tumor-suppressing effects of MSC-derived exosomes. Therefore, the exact association of MSC exosomes and tumor cells remains open to debate. This review aimed to demonstrate the present knowledge of MSC-derived exosomes in cancer research and to illustrate current approaches to make use of modified exosomes as a platform in therapeutic strategies in cancer. Keywords: mesenchymal stem cells, exosome, drug delivery, exosome engineering, cancer therapy
format	article
author	Vakhshiteh F Atyabi F Ostad SN
author_facet	Vakhshiteh F Atyabi F Ostad SN
author_sort	Vakhshiteh F
title	Mesenchymal stem cell exosomes: a two-edged sword in cancer therapy
title_short	Mesenchymal stem cell exosomes: a two-edged sword in cancer therapy
title_full	Mesenchymal stem cell exosomes: a two-edged sword in cancer therapy
title_fullStr	Mesenchymal stem cell exosomes: a two-edged sword in cancer therapy
title_full_unstemmed	Mesenchymal stem cell exosomes: a two-edged sword in cancer therapy
title_sort	mesenchymal stem cell exosomes: a two-edged sword in cancer therapy
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/4f1417b178074980adf2bfc36caa648b
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Mesenchymal stem cell exosomes: a two-edged sword in cancer therapy

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