Prion remains infectious after passage through digestive system of American crows (Corvus brachyrhynchos).

Avian scavengers, such as American crows (Corvus brachyrhynchos), have potential to translocate infectious agents (prions) of transmissible spongiform encephalopathy (TSE) diseases including chronic wasting disease, scrapie, and bovine spongiform encephalopathy. We inoculated mice with fecal extract...

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Autores principales:	Kurt C VerCauteren, John L Pilon, Paul B Nash, Gregory E Phillips, Justin W Fischer
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4f1472048851486b8d9e98f1c9563712
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spelling	oai:doaj.org-article:4f1472048851486b8d9e98f1c95637122021-11-18T08:11:46ZPrion remains infectious after passage through digestive system of American crows (Corvus brachyrhynchos).1932-620310.1371/journal.pone.0045774https://doaj.org/article/4f1472048851486b8d9e98f1c95637122012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23082115/?tool=EBIhttps://doaj.org/toc/1932-6203Avian scavengers, such as American crows (Corvus brachyrhynchos), have potential to translocate infectious agents (prions) of transmissible spongiform encephalopathy (TSE) diseases including chronic wasting disease, scrapie, and bovine spongiform encephalopathy. We inoculated mice with fecal extracts obtained from 20 American crows that were force-fed material infected with RML-strain scrapie prions. These mice all evinced severe neurological dysfunction 196-231 d postinoculation (x =198; 95% CI: 210-216) and tested positive for prion disease. Our results suggest a large proportion of crows that consume prion-positive tissue are capable of passing infectious prions in their feces (ˆp=1.0; 95% CI: 0.8-1.0). Therefore, this common, migratory North American scavenger could play a role in the geographic spread of TSE diseases.Kurt C VerCauterenJohn L PilonPaul B NashGregory E PhillipsJustin W FischerPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 10, p e45774 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kurt C VerCauteren John L Pilon Paul B Nash Gregory E Phillips Justin W Fischer Prion remains infectious after passage through digestive system of American crows (Corvus brachyrhynchos).
description	Avian scavengers, such as American crows (Corvus brachyrhynchos), have potential to translocate infectious agents (prions) of transmissible spongiform encephalopathy (TSE) diseases including chronic wasting disease, scrapie, and bovine spongiform encephalopathy. We inoculated mice with fecal extracts obtained from 20 American crows that were force-fed material infected with RML-strain scrapie prions. These mice all evinced severe neurological dysfunction 196-231 d postinoculation (x =198; 95% CI: 210-216) and tested positive for prion disease. Our results suggest a large proportion of crows that consume prion-positive tissue are capable of passing infectious prions in their feces (ˆp=1.0; 95% CI: 0.8-1.0). Therefore, this common, migratory North American scavenger could play a role in the geographic spread of TSE diseases.
format	article
author	Kurt C VerCauteren John L Pilon Paul B Nash Gregory E Phillips Justin W Fischer
author_facet	Kurt C VerCauteren John L Pilon Paul B Nash Gregory E Phillips Justin W Fischer
author_sort	Kurt C VerCauteren
title	Prion remains infectious after passage through digestive system of American crows (Corvus brachyrhynchos).
title_short	Prion remains infectious after passage through digestive system of American crows (Corvus brachyrhynchos).
title_full	Prion remains infectious after passage through digestive system of American crows (Corvus brachyrhynchos).
title_fullStr	Prion remains infectious after passage through digestive system of American crows (Corvus brachyrhynchos).
title_full_unstemmed	Prion remains infectious after passage through digestive system of American crows (Corvus brachyrhynchos).
title_sort	prion remains infectious after passage through digestive system of american crows (corvus brachyrhynchos).
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/4f1472048851486b8d9e98f1c9563712
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Prion remains infectious after passage through digestive system of American crows (Corvus brachyrhynchos).

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