Invasive infections due to Magnusiomyces capitatus: case report and review of its prevalence in China
Magnusiomyces capitatus is an emerging opportunistic yeast, thus far mainly reported from the Western world where fungemia is the most frequent presentation in immunocompromised patients with high mortality. We described a rare case of Magnusiomyces capitatus infection from our hospital in China and...
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Taylor & Francis Group
2021
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oai:doaj.org-article:4f151d9eadad4b4d806c6859733cba3a2021-11-26T11:19:49ZInvasive infections due to Magnusiomyces capitatus: case report and review of its prevalence in China2150-12032150-121110.1080/21501203.2021.2000059https://doaj.org/article/4f151d9eadad4b4d806c6859733cba3a2021-11-01T00:00:00Zhttp://dx.doi.org/10.1080/21501203.2021.2000059https://doaj.org/toc/2150-1203https://doaj.org/toc/2150-1211Magnusiomyces capitatus is an emerging opportunistic yeast, thus far mainly reported from the Western world where fungemia is the most frequent presentation in immunocompromised patients with high mortality. We described a rare case of Magnusiomyces capitatus infection from our hospital in China and reviewed six further cases published to date in Chinese literature. It is noted that half more of the cases (4/7) presented with fungemia in younger, immunosuppressed patients, whereas the remaining cases were with pneumonia in elderly, immunocompetent patients. All seven Chinese cases had favourable outcome with antifungal therapy. Based on the limited in vitro and clinical data, a combination of amphotericin B either with 5-fluorocytosine or voriconazole for fungemia in immunocompromised patients, and although fluconazole is not recommended as first-line therapy in the guideline, in our study, fluconazole alone or with 5-fluorocytosine for local pulmonary infection in immunocompetent patients is effective with good outcome.Mingxun ZhuLiang YanSybren de HoogWanqing LiaoHong ZhangRongfen ZhaoShuwen DengTaylor & Francis Grouparticlemagnusiomyces capitatussaprochaete capitata/geotrichum capitatumfungemiainvasive fungal infectionchinaBiology (General)QH301-705.5MicrobiologyQR1-502ENMycology, Vol 0, Iss 0, Pp 1-5 (2021) |
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DOAJ |
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EN |
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magnusiomyces capitatus saprochaete capitata/geotrichum capitatum fungemia invasive fungal infection china Biology (General) QH301-705.5 Microbiology QR1-502 |
| spellingShingle |
magnusiomyces capitatus saprochaete capitata/geotrichum capitatum fungemia invasive fungal infection china Biology (General) QH301-705.5 Microbiology QR1-502 Mingxun Zhu Liang Yan Sybren de Hoog Wanqing Liao Hong Zhang Rongfen Zhao Shuwen Deng Invasive infections due to Magnusiomyces capitatus: case report and review of its prevalence in China |
| description |
Magnusiomyces capitatus is an emerging opportunistic yeast, thus far mainly reported from the Western world where fungemia is the most frequent presentation in immunocompromised patients with high mortality. We described a rare case of Magnusiomyces capitatus infection from our hospital in China and reviewed six further cases published to date in Chinese literature. It is noted that half more of the cases (4/7) presented with fungemia in younger, immunosuppressed patients, whereas the remaining cases were with pneumonia in elderly, immunocompetent patients. All seven Chinese cases had favourable outcome with antifungal therapy. Based on the limited in vitro and clinical data, a combination of amphotericin B either with 5-fluorocytosine or voriconazole for fungemia in immunocompromised patients, and although fluconazole is not recommended as first-line therapy in the guideline, in our study, fluconazole alone or with 5-fluorocytosine for local pulmonary infection in immunocompetent patients is effective with good outcome. |
| format |
article |
| author |
Mingxun Zhu Liang Yan Sybren de Hoog Wanqing Liao Hong Zhang Rongfen Zhao Shuwen Deng |
| author_facet |
Mingxun Zhu Liang Yan Sybren de Hoog Wanqing Liao Hong Zhang Rongfen Zhao Shuwen Deng |
| author_sort |
Mingxun Zhu |
| title |
Invasive infections due to Magnusiomyces capitatus: case report and review of its prevalence in China |
| title_short |
Invasive infections due to Magnusiomyces capitatus: case report and review of its prevalence in China |
| title_full |
Invasive infections due to Magnusiomyces capitatus: case report and review of its prevalence in China |
| title_fullStr |
Invasive infections due to Magnusiomyces capitatus: case report and review of its prevalence in China |
| title_full_unstemmed |
Invasive infections due to Magnusiomyces capitatus: case report and review of its prevalence in China |
| title_sort |
invasive infections due to magnusiomyces capitatus: case report and review of its prevalence in china |
| publisher |
Taylor & Francis Group |
| publishDate |
2021 |
| url |
https://doaj.org/article/4f151d9eadad4b4d806c6859733cba3a |
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