Highly effective photothermal chemotherapy with pH-responsive polymer-coated drug-loaded melanin-like nanoparticles

Chengwei Zhang,1 Xiaozhi Zhao,1 Suhan Guo,2 Tingsheng Lin,1 Hongqian Guo1 1Department of Urology, Nanjing Drum Tower Hospital, Medical School of Nanjing University, Institute of Urology, Nanjing University, 2School of Public Health, Nanjing Medical University, Nanjing, People’s Republic o...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Zhang C, Zhao X, Guo S, Lin T, Guo H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	prostate cancer nanoparticles photothermal therapy dopamine drug delivery Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/4f15591a84bb40c289803de5ba9f93b5
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4f15591a84bb40c289803de5ba9f93b5
record_format	dspace
spelling	oai:doaj.org-article:4f15591a84bb40c289803de5ba9f93b52021-12-02T03:54:12ZHighly effective photothermal chemotherapy with pH-responsive polymer-coated drug-loaded melanin-like nanoparticles1178-2013https://doaj.org/article/4f15591a84bb40c289803de5ba9f93b52017-03-01T00:00:00Zhttps://www.dovepress.com/highly-effective-photothermal-chemotherapy-with-ph-responsive-polymer--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Chengwei Zhang,1 Xiaozhi Zhao,1 Suhan Guo,2 Tingsheng Lin,1 Hongqian Guo1 1Department of Urology, Nanjing Drum Tower Hospital, Medical School of Nanjing University, Institute of Urology, Nanjing University, 2School of Public Health, Nanjing Medical University, Nanjing, People’s Republic of China Abstract: Dopamine is a neurotransmitter commonly used in clinical treatment. Polydopamine (PDA) has excellent histocompatibility and biosafety and can efficiently convert near-infrared reflection (NIR) to thermal energy. In this study, PDA was used as a promising carrier, and pH-responsive polymer-coated drug-loaded PDA nanoparticles (NPs; doxorubicin@poly(allylamine)-citraconic anhydride [Dox@PAH-cit]/PDA NPs) were developed. As expected, the Dox@PAH-cit/PDA NPs exhibited excellent photothermal efficiency. In addition, at a low pH condition, the loaded Dox was released from the NPs due to the amide hydrolysis of PAH-cit. Upon NIR exposure (808 nm), the temperature of the NP solution rapidly increases to kill tumor cells. Compared with unbound chemotherapy drugs, the NPs have a stronger cell uptake ability. In vivo, the PDA NPs were able to efficiently accumulate at the tumor location. After intravenous administration and NIR exposure, tumor growth was significantly inhibited. In summary, the present investigation demonstrated that the Dox@PAH-cit/PDA NPs presented highly effective photothermal chemotherapy for prostate cancer. Keywords: prostate cancer, photothermal therapy, near-infrared reflection, dopamine, PAH-cit, drug delivery Zhang CZhao XGuo SLin TGuo HDove Medical Pressarticleprostate cancernanoparticlesphotothermal therapydopaminedrug deliveryMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 1827-1840 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	prostate cancer nanoparticles photothermal therapy dopamine drug delivery Medicine (General) R5-920
spellingShingle	prostate cancer nanoparticles photothermal therapy dopamine drug delivery Medicine (General) R5-920 Zhang C Zhao X Guo S Lin T Guo H Highly effective photothermal chemotherapy with pH-responsive polymer-coated drug-loaded melanin-like nanoparticles
description	Chengwei Zhang,1 Xiaozhi Zhao,1 Suhan Guo,2 Tingsheng Lin,1 Hongqian Guo1 1Department of Urology, Nanjing Drum Tower Hospital, Medical School of Nanjing University, Institute of Urology, Nanjing University, 2School of Public Health, Nanjing Medical University, Nanjing, People’s Republic of China Abstract: Dopamine is a neurotransmitter commonly used in clinical treatment. Polydopamine (PDA) has excellent histocompatibility and biosafety and can efficiently convert near-infrared reflection (NIR) to thermal energy. In this study, PDA was used as a promising carrier, and pH-responsive polymer-coated drug-loaded PDA nanoparticles (NPs; doxorubicin@poly(allylamine)-citraconic anhydride [Dox@PAH-cit]/PDA NPs) were developed. As expected, the Dox@PAH-cit/PDA NPs exhibited excellent photothermal efficiency. In addition, at a low pH condition, the loaded Dox was released from the NPs due to the amide hydrolysis of PAH-cit. Upon NIR exposure (808 nm), the temperature of the NP solution rapidly increases to kill tumor cells. Compared with unbound chemotherapy drugs, the NPs have a stronger cell uptake ability. In vivo, the PDA NPs were able to efficiently accumulate at the tumor location. After intravenous administration and NIR exposure, tumor growth was significantly inhibited. In summary, the present investigation demonstrated that the Dox@PAH-cit/PDA NPs presented highly effective photothermal chemotherapy for prostate cancer. Keywords: prostate cancer, photothermal therapy, near-infrared reflection, dopamine, PAH-cit, drug delivery
format	article
author	Zhang C Zhao X Guo S Lin T Guo H
author_facet	Zhang C Zhao X Guo S Lin T Guo H
author_sort	Zhang C
title	Highly effective photothermal chemotherapy with pH-responsive polymer-coated drug-loaded melanin-like nanoparticles
title_short	Highly effective photothermal chemotherapy with pH-responsive polymer-coated drug-loaded melanin-like nanoparticles
title_full	Highly effective photothermal chemotherapy with pH-responsive polymer-coated drug-loaded melanin-like nanoparticles
title_fullStr	Highly effective photothermal chemotherapy with pH-responsive polymer-coated drug-loaded melanin-like nanoparticles
title_full_unstemmed	Highly effective photothermal chemotherapy with pH-responsive polymer-coated drug-loaded melanin-like nanoparticles
title_sort	highly effective photothermal chemotherapy with ph-responsive polymer-coated drug-loaded melanin-like nanoparticles
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/4f15591a84bb40c289803de5ba9f93b5
work_keys_str_mv	AT zhangc highlyeffectivephotothermalchemotherapywithphresponsivepolymercoateddrugloadedmelaninlikenanoparticles AT zhaox highlyeffectivephotothermalchemotherapywithphresponsivepolymercoateddrugloadedmelaninlikenanoparticles AT guos highlyeffectivephotothermalchemotherapywithphresponsivepolymercoateddrugloadedmelaninlikenanoparticles AT lint highlyeffectivephotothermalchemotherapywithphresponsivepolymercoateddrugloadedmelaninlikenanoparticles AT guoh highlyeffectivephotothermalchemotherapywithphresponsivepolymercoateddrugloadedmelaninlikenanoparticles
_version_	1718401547138760704

Highly effective photothermal chemotherapy with pH-responsive polymer-coated drug-loaded melanin-like nanoparticles

Ejemplares similares